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PTCT

PTC Therapeutics

$37.57

-0.75 (-1.96%)

, RHHBY

Roche

$0.00

(0.00%)

16:18
06/17/18
06/17
16:18
06/17/18
16:18

PTC Therapeutics presents updated preliminary data from SMA FIREFISH Program

PTC Therapeutics (PTCT) announced the presentation of updated interim clinical data from Part 1 of the FIREFISH study investigating risdiplam in babies with Type 1 Spinal Muscular Atrophy, at the 22nd Annual SMA Researcher Meeting. The data presented demonstrated that at Day 182, over 90% of the babies achieved a greater than 4-point increase in CHOP-INTEND score compared to baseline. The CHOP-INTEND data were further supported by video footage presented by Dr Baranello demonstrating antigravity movements, the ability to control their head, roll, or sit in babies participating in FIREFISH. Part 2 of the pivotal FIREFISH study is ongoing. The SMA program is a collaboration between PTC, Roche (RHHBY), and the SMA Foundation. Other presentations included an analysis of data from Part 1 of the SUNFISH study which demonstrated that risdiplam administration resulted in a dose-dependent increase in SMN protein levels up to 3.5-fold; pharmacodynamic data from the JEWELFISH trial; and preclinical data demonstrating SMN protein production and distribution, as well as the development of the SMA Independence Scale.

PTCT

PTC Therapeutics

$37.57

-0.75 (-1.96%)

RHHBY

Roche

$0.00

(0.00%)

PTCT PTC Therapeutics
$37.57

-0.75 (-1.96%)

04/04/18
04/04/18
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. PTC Therapeutics (PTCT) downgraded to Underweight from Equal Weight at Barclays with analyst Gena Wang saying she sees limited upside to 2018 revenue expectations and believes PTC's growth trajectory is fully priced in at current valuation levels. 2. Cloudera (CLDR) downgraded to Neutral from Overweight at JPMorgan and to Hold from Buy at Deutsche Bank. 3. Domino's Pizza (DPZ) downgraded to Hold from Buy at Deutsche Bank with analyst Brett Levy citing valuation. 4. Virtusa (VRTU) downgraded to Hold from Buy at SunTrust with analyst Frank Atkins saying while Virtusa stock has risen 166% since November of 2016, future upside may be more limited. 5. ResMed (RMD) downgraded to Neutral from Buy at Citi with analyst Victor Windeyer citing valuation. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, Reference Link
04/03/18
LEHM
04/03/18
DOWNGRADE
Target $26
LEHM
Underweight
Barclays downgrades PTC Therapeutics to Underweight with $26 target
Barclays analyst Gena Wang downgraded PTC Therapeutics to Underweight from Equal Weight while raising her price target for the shares to $26 from $24. The stock closed the trading day up 15c to $26.12. The analyst sees limited upside to 2018 revenue expectations and believes PTC's growth trajectory is fully priced in at current valuation levels.
04/03/18
LEHM
04/03/18
DOWNGRADE
LEHM
Underweight
PTC Therapeutics downgraded to Underweight from Equal Weight at Barclays
02/21/18
SBSH
02/21/18
NO CHANGE
Target $35
SBSH
Buy
PTC Therapeutics price target raised to $35 from $24 at Citi
Citi analyst Joel Beatty raised his price target for PTC Therapeutics to $35 on expectations that outside the U.S. Translarna sales and U.S. Emflaza sales growth will continue in 2018. Further, the analyst sees the potential for upside from additional Phase 2 data on spinal muscular atrophy agent RG7916 and from a trial design update on plans to generate dystrophin production data for Translarna in pursuit of accelerated approval. Beatty added U.S. Translarna sales back into his model, probability-adjusted at 10%, after yesterday's update from PTC that FDA will allow an accelerated approval pathway to be pursued for the drug. The analyst keeps a Buy rating on the shares.
RHHBY Roche
$0.00

(0.00%)

06/13/18
MSCO
06/13/18
NO CHANGE
MSCO
HHS 'smoke signals' worth noting for drugmakers, says Morgan Stanley
After HHS Secretary Alex Azar spoke at a two-hour Senate hearing, Morgan Stanley analyst David Risinger noted that Azar suggested that U.S. drug pricing needs to move to a system without rebates and said payments from drugmakers to PBMs should be eliminated. In listing four HHS actions that could hurt manufacturers, Risinger pointed out that Azar said he is interested in removing 100% cap on Medicaid rebates; he would like to adjust the Part D protected drug classes so that plans can extract rebates from manufacturers; HHS wants to require manufacturers to disclose drug list prices in TV ads; and HHS is focused on transitioning Part B to lower-priced private sector management. In summary, the analyst said that for drugmakers there was "no fire, but smoke signals worth noting." Publicly traded large-cap drugmakers include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).
05/25/18
05/25/18
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Ultra Petroleum (UPL) downgraded to Hold from Buy at Stifel analyst Michael Scialla saying that supply growth appears set to outpace incremental demand from LNG exports, Mexican exports, and industrial sources. 2. Zoe's Kitchen (ZOES) downgraded to Market Perform from Outperform at William Blair, to Hold from Buy at Maxim, and to Underweight from Neutral at Piper Jaffray. 3. Roche (RHHBY) downgraded to Underperform from Neutral at Credit Suisse. 4. 8x8, Inc. (EGHT) downgraded to Neutral from Buy at BofA/Merrill with analyst Nikolay Beliov saying 8x8, Inc. reported a Q4 revenue beat but missed on margins again due to increased investment. 5. First Cash Financial (FCFS) downgraded to Neutral from Outperform at Credit Suisse. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
05/25/18
FBCO
05/25/18
DOWNGRADE
FBCO
Underperform
Roche downgraded to Underperform from Neutral at Credit Suisse
05/16/18
PIPR
05/16/18
NO CHANGE
PIPR
Piper survey shows growth in non-invasive prenatal test volumes
Piper Jaffray analyst William Quirk says his firm's annual survey of obstetricians and gynecologists suggests "significant" near-term growth in average-risk non-invasive prenatal test volume. This is good for Quest Diagnostics (DGX), Illumina (ILMN), LabCorp (LH), Natera (NTRA) and Roche (RHHBY), Quirk tells investors in a research note. Piper found that the number of doctors offering non-invasive prenatal tests to average risk patients increased to 59% in 2018 from 35% last year. Lack of reimbursement remains a barrier to more testing, but importantly, for the second year in a row, resistance to offering NIPT due to Medicaid and clinical data declined, Quirk adds.

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FB

Facebook

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Wells Fargo

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SCHW

Charles Schwab

$50.62

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FNGN

Financial Engines

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Financial Engines to host special shareholder meeting »

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Nevro

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Tesla

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Comcast

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Comcast

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Sony

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FOX

21st Century Fox

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21st Century Fox

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Lionsgate

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Disney

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Viacom

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Viacom

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Amazon.com

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EADSY

Airbus

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Airbus near deal to sell A350s to StarLux, Reuters reports »

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TWTR

Twitter

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12:44
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Twitter suspends accounts linked to Russians indicted by Mueller, Reuters says »

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SPY

SPDR S&P 500 ETF Trust

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12:29
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Trump says he will run for reelection, Reuters reports »

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SPDR S&P 500 ETF Trust

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EADSY

Airbus

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12:22
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Airbus in talks for repeat Viva Aerobus jet order, Reuters says »

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BA

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SPDR S&P 500 ETF Trust

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L3 Technologies appoints new SVP, Chief Global Business Development Officer »

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Facebook

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Twitter

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Facebook, Alphabet to testify at U.S. House hearing, Reuters reports »

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Facebook

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Twitter

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GOOG

Alphabet

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Alphabet Class A

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AAPL

Apple

$191.32

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, T

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Apple's next iPhone may be debut of eSIM, Barron's says »

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Apple

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Verizon

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Sprint

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American Electric

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NextEra Energy

$169.60

1.06 (0.63%)

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Utility stocks worth a second look, Barron's says »

Utility stocks like…

AEP

American Electric

$70.37

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NextEra Energy

$169.60

1.06 (0.63%)

XEL

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Broadcom

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CA Technologies

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VRX

Valeant

$23.40

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Herbalife Nutrition

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VRX

Valeant

$23.40

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HLF

Herbalife Nutrition

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ARNC

Arconic

$17.39

0.08 (0.46%)

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Apollo Global

$36.13

0.26 (0.72%)

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Apollo, other PE firms express interest in Arconic, WSJ reports »

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Arconic

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Apollo Global

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PFE

Pfizer

$37.53

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Alibaba

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PFE

Pfizer

$37.53

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BABA

Alibaba

$190.03

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BIDU

Baidu

$267.20

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JD

JD.com

$38.27

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IQ

iQIYI

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VIPS

Vipshop

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NYT

New York Times

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PLNT

Planet Fitness

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XYL

Xylem

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Evoqua Water

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RBC Capital to hold a field trip »

Asia Water Sector Field…

XYL

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Danaher

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Pentair

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HJLI

Hancock Jaffe Laboratories

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18:20
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Hancock Jaffe Laboratories names Bob Rankin as CFO, effective July 16 »

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