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VVUS

VIVUS

$0.75

0.0163 (2.22%)

07:37
07/10/18
07/10
07:37
07/10/18
07:37

VIVUS announces 'positive' results from Phase 1 clinical trial of VI-0106

VIVUS announced positive preliminary results from a Phase 1 clinical study evaluating the pharmacokinetic profile of its VI-0106 in healthy volunteers. VIVUS is developing VI-0106, a proprietary soft capsule formulation of tacrolimus for the treatment of pulmonary arterial hypertension, a degenerative disease that makes it difficult for the heart to pump blood through the lungs to be oxygenated and may ultimately lead to heart failure. The U.S. Food and Drug Administration approved tacrolimus in 1994 for use in lowering the risk of organ rejection in patients undergoing kidney transplant, and the drug is currently indicated for use in additional organ transplant settings and to treat atopic dermatitis. Tacrolimus has been shown to increase signaling through the bone morphogenetic protein receptor 2 pathway, which is down-regulated in PAH patients. The single-center, UK-based Phase 1 PK study was conducted in two parts. Sixteen healthy volunteers were enrolled in Part 1 and each patient sequentially received single doses of three different tacrolimus prototype regimens administered at least 10 days apart. An interim analysis was conducted following the third dosing period to select a formulation prototype with the most desirable PK profile. Three subsequent periods assessed the selected formulation at different doses, or under different fed/fasted conditions. The second part of the study evaluated steady-state PK parameters in 12 healthy volunteers receiving daily doses of the selected prototype formulation. VIVUS is developing VI-0106 under the FDA's 505(B)(2) regulatory pathway, which will allow the Company to leverage the FDA's finding of safety and effectiveness for tacrolimus as well as a significant body of previously published tacrolimus safety and efficacy data. This is expected to reduce the time and cost to develop VI-0106 as a potential breakthrough therapy for the treatment of PAH. In September 2017, results of a university-run Phase 2a clinical study of tacrolimus in patients with PAH were published in the European Respiratory Journal. Study results demonstrate the safety of tacrolimus in patients with PAH. The currently approved formulation of VI-0106 tacrolimus was also provided for compassionate use in three class 3 or 4 PAH patients. The compassionate use demonstrated dramatically reduced rates of hospitalizations and functional class improvements were observed. VIVUS believes that VI-0106 could become an important new treatment option for PAH patients and intends to request both Fast Track and Breakthrough Therapy Designation from the FDA for VI-0106 in this indication.

  • 07

    Sep

TODAY'S FREE FLY STORIES

ACN

Accenture

$166.47

-0.47 (-0.28%)

, EADSY

Airbus

$0.00

(0.00%)

04:55
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07/22
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04:55
Conference/Events
Farnborough International to hold an airshow »

Farnborough International…

ACN

Accenture

$166.47

-0.47 (-0.28%)

EADSY

Airbus

$0.00

(0.00%)

ATI

Allegheny Technologies

$26.65

0.08 (0.30%)

BAESY

BAE Systems

$0.00

(0.00%)

BDRBF

Bombardier

$0.00

(0.00%)

CAE

CAE

$20.96

0.17 (0.82%)

CW

Curtiss-Wright

$125.79

-0.12 (-0.10%)

DASTY

Dassault Systemes

$0.00

(0.00%)

ESLT

Elbit Systems

$118.98

0.64 (0.54%)

LMT

Lockheed Martin

$322.76

3.09 (0.97%)

BA

Boeing

$354.92

-0.57 (-0.16%)

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FCAU

Fiat Chrysler

$19.33

-0.195 (-1.00%)

13:14
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Fiat names Jeep head as CEO as Marchionne's health worsens »

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RACE

Ferrari

$139.98

-2.65 (-1.86%)

, PM

Philip Morris

$84.31

3.41 (4.22%)

13:10
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Ferrari to name former Philip Morris chairman as CEO »

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Ferrari

$139.98

-2.65 (-1.86%)

PM

Philip Morris

$84.31

3.41 (4.22%)

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  • 01

    Aug

AMZN

Amazon.com

$1,813.84

0.99 (0.05%)

, TM

Toyota

$131.87

0.11 (0.08%)

12:51
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Amazon, others working to counter Trump's tariff plans, Reuters says »

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AMZN

Amazon.com

$1,813.84

0.99 (0.05%)

TM

Toyota

$131.87

0.11 (0.08%)

AA

Alcoa

$40.32

-1.36 (-3.26%)

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FCAU

Fiat Chrysler

$19.33

-0.195 (-1.00%)

12:47
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12:47
Periodicals
Fiat Chrysler's Sergio Marchionne to step down, NYTimes reports »

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FCAU

Fiat Chrysler

$19.33

-0.195 (-1.00%)

12:43
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Periodicals
Fiat Chrysler to name Jeep's Manley as CEO, Reuters reports »

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BABA

Alibaba

$187.21

-0.14 (-0.07%)

, TCEHY

Tencent

$0.00

(0.00%)

12:40
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Alibaba, Tencent in talks to buy stake in WPP's Chinese unit, Reuters says »

Alibaba (BABA) and…

BABA

Alibaba

$187.21

-0.14 (-0.07%)

TCEHY

Tencent

$0.00

(0.00%)

WPP

WPP

$76.08

1.52 (2.04%)

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  • 10

    Sep

AMZN

Amazon.com

$1,813.84

0.99 (0.05%)

, NFLX

Netflix

$361.33

-2.81 (-0.77%)

11:24
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11:24
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Amazon, Netflix to face tighter capital markets, Barron's says »

Since the Great…

AMZN

Amazon.com

$1,813.84

0.99 (0.05%)

NFLX

Netflix

$361.33

-2.81 (-0.77%)

TSLA

Tesla

$313.49

-6.85 (-2.14%)

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AB

AllianceBernstein

$29.90

-0.05 (-0.17%)

, BLK

BlackRock

$503.01

-1.42 (-0.28%)

11:17
07/21/18
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Periodicals
BlackRock, T. Rowe Price look like bargains, Barron's says »

With shares of many…

AB

AllianceBernstein

$29.90

-0.05 (-0.17%)

BLK

BlackRock

$503.01

-1.42 (-0.28%)

BEN

Franklin Resources

$31.99

-0.28 (-0.87%)

IVZ

Invesco

$25.46

-0.245 (-0.95%)

LM

Legg Mason

$33.37

-0.13 (-0.39%)

TROW

T. Rowe Price

$119.87

-0.85 (-0.70%)

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ALV

Autoliv

$104.08

-0.57 (-0.54%)

, VNE

Veoneer

$50.81

-1.81 (-3.44%)

11:12
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Automotive spinoffs offer exposure to autonomous, electric future, Barron's says »

Last month, Autoliv (ALV)…

ALV

Autoliv

$104.08

-0.57 (-0.54%)

VNE

Veoneer

$50.81

-1.81 (-3.44%)

DLPH

Delphi Technologies

$44.78

-0.355 (-0.79%)

APTV

Aptiv

$92.95

-2.02 (-2.13%)

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DDAIF

Daimler AG

$0.00

(0.00%)

, FCAU

Fiat Chrysler

$19.33

-0.195 (-1.00%)

07:58
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Hot Stocks
Week in review: How Trump's policies moved stocks »

Catch up on the top…

DDAIF

Daimler AG

$0.00

(0.00%)

FCAU

Fiat Chrysler

$19.33

-0.195 (-1.00%)

F

Ford

$10.56

-0.115 (-1.08%)

GM

General Motors

$39.39

0.08 (0.20%)

HMC

Honda

$29.18

-0.19 (-0.65%)

NSANY

Nissan

$0.00

(0.00%)

TM

Toyota

$131.87

0.11 (0.08%)

VLKAY

Volkswagen

$0.00

(0.00%)

GOOG

Alphabet

$1,184.77

-2.37 (-0.20%)

GOOGL

Alphabet Class A

$1,198.05

-1.21 (-0.10%)

PFE

Pfizer

$37.33

-0.03 (-0.08%)

NVS

Novartis

$82.28

1.47 (1.82%)

RHHBY

Roche

$0.00

(0.00%)

SNY

Sanofi

$42.38

0.44 (1.05%)

BA

Boeing

$354.92

-0.57 (-0.16%)

MRK

Merck

$62.51

(0.00%)

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ACN

Accenture

$166.47

-0.47 (-0.28%)

, EADSY

Airbus

$0.00

(0.00%)

04:55
07/21/18
07/21
04:55
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04:55
Conference/Events
Farnborough International to hold an airshow »

Farnborough International…

ACN

Accenture

$166.47

-0.47 (-0.28%)

EADSY

Airbus

$0.00

(0.00%)

ATI

Allegheny Technologies

$26.65

0.08 (0.30%)

BAESY

BAE Systems

$0.00

(0.00%)

BDRBF

Bombardier

$0.00

(0.00%)

CAE

CAE

$20.96

0.17 (0.82%)

CW

Curtiss-Wright

$125.79

-0.12 (-0.10%)

DASTY

Dassault Systemes

$0.00

(0.00%)

ESLT

Elbit Systems

$118.98

0.64 (0.54%)

LMT

Lockheed Martin

$322.76

3.09 (0.97%)

BA

Boeing

$354.92

-0.57 (-0.16%)

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    Aug

FNWB

First Northwest Bancorp

$16.11

0.36 (2.29%)

17:48
07/20/18
07/20
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17:48
Hot Stocks
First Northwest Bancorp names Terry Anderson chief credit officer »

First Northwest Bancorp…

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FCX

Freeport McMoRan

$15.75

-0.05 (-0.32%)

17:42
07/20/18
07/20
17:42
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17:42
Hot Stocks
Freeport McMoRan CAO Michael Arnold to retire »

In a regulatory filing,…

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XLE

Energy Select Sector SPDR

$74.87

-0.24 (-0.32%)

, XLU

Utilities SPDR

$52.28

-0.39 (-0.74%)

17:39
07/20/18
07/20
17:39
07/20/18
17:39
General news
Week ending ETF Scorecard: Financials lead, Energy slumps »

S&P500 SECTORS:…

XLE

Energy Select Sector SPDR

$74.87

-0.24 (-0.32%)

XLU

Utilities SPDR

$52.28

-0.39 (-0.74%)

IYR

DJ US Real Estate Index Fund

$80.23

-0.68 (-0.84%)

XLP

Consumer Staples Sector SPDR

$52.84

0.3 (0.57%)

XLY

Consumer Discretionary Sector SPDR

$112.15

-0.47 (-0.42%)

XLB

S&P Select Materials SPDR

$58.31

-0.21 (-0.36%)

XLF

Financial Select Sector

$27.57

0.065 (0.24%)

XLV

Health Care Select Sector SPDR

$86.74

-0.17 (-0.20%)

XLK

Technology Select Sector SPDR

$72.55

0.01 (0.01%)

XLI

Industrial Select Sector SPDR

$74.44

-0.09 (-0.12%)

GLD

SPDR Gold Trust

$116.56

0.74 (0.64%)

SLV

iShares Silver Trust

$14.59

0.18 (1.25%)

USO

United States Oil Fund

$14.15

0.025 (0.18%)

UNG

United States Natural Gas Fund

$22.38

-0.06 (-0.27%)

HYG

iShares iBoxx $ High Yield Corporate Bond

$85.62

0.03 (0.04%)

LQD

iShares iBoxx $ Investment Grade Corporate Bond

$115.27

-0.335 (-0.29%)

TLT

iShares 20+ Year Treasury Bond Fund

$120.78

-1.46 (-1.19%)

IEF

iShares 7-10 Year Treasury Bond ETF

$102.21

-0.35 (-0.34%)

SHY

iShares 1-3 Year Treasury Bond

$83.26

-0.005 (-0.01%)

IWD

iShares Russell 1000 Value

$123.07

-0.2897 (-0.23%)

IWF

iShares Russell 1000 Growth

$149.41

-0.04 (-0.03%)

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XRX

Xerox

$25.10

-0.095 (-0.38%)

, FUJIY

Fujifilm

$0.00

(0.00%)

17:25
07/20/18
07/20
17:25
07/20/18
17:25
Hot Stocks
Xerox, Centerview settle matters related to proposed Fuji tie-up »

On July 20, 2018, Xerox…

XRX

Xerox

$25.10

-0.095 (-0.38%)

FUJIY

Fujifilm

$0.00

(0.00%)

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  • 26

    Jul

STON

StoneMor Partners

$3.61

-0.015 (-0.41%)

17:15
07/20/18
07/20
17:15
07/20/18
17:15
Hot Stocks
Breaking Hot Stocks news story on StoneMor Partners »

Oaktree Capital reports…

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TEF

Telefonica

$8.70

0.07 (0.81%)

17:11
07/20/18
07/20
17:11
07/20/18
17:11
Downgrade
Telefonica rating change at Goldman Sachs »

Telefonica downgraded to…

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SPY

SPDR S&P 500 ETF Trust

$279.71

-0.24 (-0.09%)

, USO

United States Oil Fund

$14.15

0.025 (0.18%)

17:04
07/20/18
07/20
17:04
07/20/18
17:04
General news
Weekly CFTC Commitment of Traders highlights »

S&P500 net long 5.5K…

SPY

SPDR S&P 500 ETF Trust

$279.71

-0.24 (-0.09%)

USO

United States Oil Fund

$14.15

0.025 (0.18%)

GLD

SPDR Gold Trust

$116.56

0.74 (0.64%)

FXE

Euro Currency Trust

$112.46

0.83 (0.74%)

FXC

CurrencyShares Canadian Dollar Trust

$75.17

0.81 (1.09%)

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CZWI

Citizens Community Bancorp

$14.15

(0.00%)

17:02
07/20/18
07/20
17:02
07/20/18
17:02
Syndicate
Breaking Syndicate news story on Citizens Community Bancorp »

Citizens Community…

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PKD

Parker Drilling

$0.30

-0.0044 (-1.46%)

17:01
07/20/18
07/20
17:01
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17:01
Hot Stocks
Breaking Hot Stocks news story on Parker Drilling »

Whitebox Advisors reports…

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  • 02

    Aug

RSLS

ReShape Lifesciences

$1.47

-0.02 (-1.34%)

17:00
07/20/18
07/20
17:00
07/20/18
17:00
Hot Stocks
Breaking Hot Stocks news story on ReShape Lifesciences  »

Intracoastal Capital…

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BOX

Box

$26.13

-0.26 (-0.99%)

16:57
07/20/18
07/20
16:57
07/20/18
16:57
Initiation
Box initiated at First Analysis »

Box initiated with an…

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ALDX

Aldeyra

$7.95

-0.15 (-1.85%)

16:53
07/20/18
07/20
16:53
07/20/18
16:53
Syndicate
Breaking Syndicate news story on Aldeyra »

Aldeyra files $250M mixed…

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GLRE

Greenlight Capital Re

$14.00

-0.15 (-1.06%)

16:46
07/20/18
07/20
16:46
07/20/18
16:46
Hot Stocks
Greenlight Capital Re announces departure of COO »

Greenlight Capital Ry…

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