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VBLT

VBL Therapeutics

$2.15

(0.00%)

08:12
07/10/18
07/10
08:12
07/10/18
08:12

VBL says data shows MOSPD2 can play major role in breast cancer cell migration

VBL Therapeutics announced the publication of data on the potential role of MOSPD2 in metastatic breast cancer in the International Journal of Cancer. VBL's data demonstrate for the first time that MOSPD2 can play a major role in breast cancer cell migration and metastasis, and that targeting MOSPD2 may be employed to prevent the spreading of breast cancer cells. Histological analysis of specimens shows that MOSPD2 levels were correlated with the stage of tumor invasiveness, and were profoundly elevated in invasive and metastatic breast cancer, making it an attractive target for potential treatment of late-stage breast cancer. At the American Association of Cancer Research conference in April this year, VBL presented a late-breaking proof-of-concept study demonstrating antibody-mediated killing of MOSPD2-expressing cancer cells. VBL research has also shown that knocking-out the MOSPD2 gene in mice could protect the animals from developing some inflammatory diseases. The Company has generated antibodies that block immune cell migration and show efficacy in a model of multiple sclerosis. VBL is developing the VB-600 platform of biologic drug candidates for oncology and inflammatory indications. The Company plans to file an IND in this program by year-end 2019.

VBLT VBL Therapeutics
$2.15

(0.00%)

03/08/18
03/08/18
DOWNGRADE
Target $4

Neutral
VBL Therapeutics downgraded to Neutral after rGBM study miss at Piper Jaffray
As previously reported, Piper Jaffray analyst Charles Duncan downgraded VBL Therapeutics to Neutral from Overweight and cut his price target on the stock to $4 from $13 after the company's Phase 3 GLOBE study for the treatment of recurrent glioblastoma multiforme didn't hit its primary endpoint. For now, there is low visibility on any activity signals that may have been seen in the GLOBE study, said Duncan. However, he adds that he thinks VB-111 could have a higher possibility of success in the "relatively lower bar of ovarian cancer."
03/08/18
JMPS
03/08/18
DOWNGRADE
JMPS
Market Perform
VBL Therapeutics downgraded to Market Perform from Outperform at JMP Securities
03/08/18
03/08/18
DOWNGRADE

Market Perform
VBL Therapeutics downgraded to Market Perform at JMP Securities
As previously reported, JMP Securities analyst Michael King downgraded VBL Therapeutics to Market Perform from Outperform after the company announced that the Phase III GLOBE study of VB-111 in rGBM did not meet its primary endpoint. At this time, the analyst believes the market fairly values the shares.
03/08/18
CHDN
03/08/18
DOWNGRADE
Target $3
CHDN
Neutral
VBL Therapeutics downgraded to Neutral from Buy at Chardan
Chardan analyst Gbola Amusa downgraded VBL Therapeutics to Neutral and cut his price target for the shares to $3 from $25. The analyst believes this morning's failed trial offers little reason for optimism.

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CAMP

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ELAN

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SCHW

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