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BGNE

BeiGene

$169.98

5.95 (3.63%)

16:40
07/22/18
07/22
16:40
07/22/18
16:40

BeiGene announces preliminary topline results of Hodgkin's Lymphoma trial

BeiGene announced preliminary topline results from the independent review of response data from the pivotal Phase 2 trial of tislelizumab, an investigational anti-PD-1 antibody, in Chinese patients with relapsed/refractory classical Hodgkin's lymphoma. The single-arm pivotal trial enrolled 70 patients with cHL who either failed autologous stem cell transplantation or who were ineligible for ASCT. The primary endpoint was overall response rate as defined by the Lugano 2014 criteria. Secondary endpoints included progression-free survival, duration of response, complete response rate, time to response, safety, and tolerability. As of the data cutoff, the median follow-up time was approximately 6 months. A review of responses by an independent review committee, provided in June 2018, demonstrated: the ORR was 73%, including 50% CR, and the median DOR had not been reached. Frequency and severity of adverse events were generally consistent with the previously reported Phase 1 safety and tolerability data for tislelizumab, or, in the case of certain immune-related events such as hypothyroidism and fever, consistent with previous reports of other PD-1 antibodies for the treatment of cHL.These cHL data, along with additional follow-up data from the clinical trial, are expected to be included in BeiGene's Biologics License Application planned to be filed with the China Drug Administration later this year. Tislelizumab is also being studied in global Phase 3 trials in a number of malignancies, including non-small cell lung cancer, hepatocellular carcinoma, and esophageal squamous cell carcinoma; as well as two global Phase 2 trials in patients with previously treated hepatocellular carcinoma or with R/R mature T-and NK-cell lymphomas, and an additional pivotal Phase 2 trial in China in urothelial cancer.

BGNE BeiGene
$169.98

5.95 (3.63%)

05/14/18
FBCO
05/14/18
INITIATION
FBCO
Outperform
BeiGene initiated with an Outperform at Credit Suisse
05/14/18
05/14/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. General Electric (GE) initiated with a Buy at Gabelli. 2. Western Digital (WDC) initiated with an Overweight at JPMorgan. 3. GrafTech (EAF) initiated with an Overweight at JPMorgan and an Outperform at RBC Capital. 4. Surface Oncology (SURF) initiated with an Outperform at Evercore ISI and Cowen as well as a Neutral at Goldman Sachs. 5. BeiGene (BGNE) initiated with an Outperform at Credit Suisse. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
05/18/18
MAXM
05/18/18
NO CHANGE
Target $225
MAXM
Buy
BeiGene price target raised to $225 from $200 at Maxim
Maxim analyst Jason McCarthy raised his price target on BeiGene to $225 and kept his Buy rating after the company's announced pivotal study to move into ovarian cancer treatment in China. The analyst notes that as a China-based company, BeiGene has a "distinct advantage" in potentially bringing a PARP inhibitor candidate to that market. McCarthy also points to the China market opportunity, where the majority of 50K ovarian cancer cases are moving to maintenance therapy.
06/15/18
PIPR
06/15/18
NO CHANGE
Target $200
PIPR
Overweight
Piper says BeiGene update suggests zanubrutinib at least in line with other BTKs
After BeiGene presented results on its investigational BTK inhibitor zanubrutinib at the EHA meeting, Piper Jaffray analyst Tyler Van Buren said the update suggests zanubrutinib is "at least in line with" the other BTKs and has potential for eventual differentiation. He was encouraged to see a significant increase in the complete response rate for mantle cell lymphoma and thinks the data will support an approval in China next year, he tells investors. Van Buren keeps an Overweight rating and $200 price target on BeiGene shares.

TODAY'S FREE FLY STORIES

WMT

Walmart

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-0.74 (-0.75%)

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TCEHY

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$0.00

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Amazon.com

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$0.00

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VLKAY

Volkswagen

$0.00

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WMT

Walmart

$97.89

-0.74 (-0.75%)

, TCEHY

Tencent

$0.00

(0.00%)

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WMT

Walmart

$97.89

-0.74 (-0.75%)

TCEHY

Tencent

$0.00

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MSFT

Microsoft

$107.58

-0.07 (-0.07%)

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  • 04

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BBOX

Black Box

$1.64

0.09 (5.81%)

12:57
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Black Box announces sale agreement of Federal Government IT Services Business »

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KSS

Kohl's

$76.43

1.68 (2.25%)

12:52
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Kohl's looking to break cycle, Barron's says »

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  • 21

    Aug

STT

State Street

$84.95

0.73 (0.87%)

12:47
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State Street selloff looks overdone, Barron's says »

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WMT

Walmart

$97.89

-0.74 (-0.75%)

, AMZN

Amazon.com

$1,881.94

-5.56 (-0.29%)

12:42
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Periodicals
May be time to sell Walmart, Barron's says »

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WMT

Walmart

$97.89

-0.74 (-0.75%)

AMZN

Amazon.com

$1,881.94

-5.56 (-0.29%)

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  • 13

    Sep

VZ

Verizon

$54.79

0.51 (0.94%)

12:39
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Verizon remains 'reasonably' priced, Barron's says »

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CF

CF Industries

$47.52

0.25 (0.53%)

, MOS

Mosaic

$29.64

(0.00%)

12:36
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Periodicals
CF, Mosaic gains have just begun, Barron's says »

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CF

CF Industries

$47.52

0.25 (0.53%)

MOS

Mosaic

$29.64

(0.00%)

NTR

Nutrien

$55.95

0.94 (1.71%)

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  • 11

    Sep

  • 06

    Nov

ABBV

AbbVie

$98.79

0.6 (0.61%)

, LYB

LyondellBasell

$113.07

1.155 (1.03%)

12:25
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Periodicals
StAbbVie, Starbucks among dividend standouts, Barron's says »

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ABBV

AbbVie

$98.79

0.6 (0.61%)

LYB

LyondellBasell

$113.07

1.155 (1.03%)

AVGO

Broadcom

$209.27

0.6 (0.29%)

RF

Regions Financial

$19.48

0.09 (0.46%)

SBUX

Starbucks

$53.58

0.53 (1.00%)

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  • 05

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BV

BrightView

$17.49

-0.06 (-0.34%)

12:21
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Sunny outlook for BrightView, Barron's says »

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HOG

Harley-Davidson

$42.26

1.15 (2.80%)

, CSIQ

Canadian Solar

$13.12

0.02 (0.15%)

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CSIQ

Canadian Solar

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FSLR

First Solar

$50.98

0.18 (0.35%)

JASO

JA Solar

$0.00

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SUNEQ

SunEdison

$0.00

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SPWR

SunPower

$6.65

0.06 (0.91%)

TSL

Trina Solar

$0.00

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YGE

Yingli Green Energy

$0.00

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PEP

PepsiCo

$114.98

0.7 (0.61%)

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  • 02

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LYV

Live Nation

$48.15

-0.53 (-1.09%)

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Live Nation CFO discloses sale of 40K shares of common stock »

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XLE

Energy Select Sector SPDR

$72.63

0.21 (0.29%)

, XLU

Utilities SPDR

$54.50

0.25 (0.46%)

17:40
08/17/18
08/17
17:40
08/17/18
17:40
General news
Week ending ETF Scorecard: Consumer Staples outperforms, Energy skids »

S&P500 SECTORS:…

XLE

Energy Select Sector SPDR

$72.63

0.21 (0.29%)

XLU

Utilities SPDR

$54.50

0.25 (0.46%)

IYR

DJ US Real Estate Index Fund

$83.16

0.765 (0.93%)

XLP

Consumer Staples Sector SPDR

$55.02

0.39 (0.71%)

XLY

Consumer Discretionary Sector SPDR

$112.51

0.11 (0.10%)

XLB

S&P Select Materials SPDR

$58.41

0.41 (0.71%)

XLF

Financial Select Sector

$28.16

0.055 (0.20%)

XLV

Health Care Select Sector SPDR

$91.12

0.33 (0.36%)

XLK

Technology Select Sector SPDR

$73.17

0.14 (0.19%)

XLI

Industrial Select Sector SPDR

$76.26

0.47 (0.62%)

GLD

SPDR Gold Trust

$112.12

1.01 (0.91%)

SLV

iShares Silver Trust

$13.93

0.16 (1.16%)

USO

United States Oil Fund

$13.70

0.065 (0.48%)

UNG

United States Natural Gas Fund

$24.18

0.295 (1.24%)

HYG

iShares iBoxx $ High Yield Corporate Bond

$86.03

0.08 (0.09%)

LQD

iShares iBoxx $ Investment Grade Corporate Bond

$115.97

0.11 (0.09%)

TLT

iShares 20+ Year Treasury Bond Fund

$120.99

0.16 (0.13%)

IEF

iShares 7-10 Year Treasury Bond ETF

$102.49

0.04 (0.04%)

SHY

iShares 1-3 Year Treasury Bond

$83.28

0.03 (0.04%)

IWD

iShares Russell 1000 Value

$126.16

0.6 (0.48%)

IWF

iShares Russell 1000 Growth

$150.80

0.27 (0.18%)

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GLD

SPDR Gold Trust

$112.12

1.01 (0.91%)

17:33
08/17/18
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Hot Stocks
SPDR Gold Trust holdings fall to 772.24MT from 773.41MT »

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GDOT

Green Dot

$85.04

0.37 (0.44%)

17:30
08/17/18
08/17
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17:30
Hot Stocks
Green Dot exec Dent sells 7,754 common shares »

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  • 25

    Sep

SMSI

Smith Micro

$2.49

-0.01 (-0.40%)

17:17
08/17/18
08/17
17:17
08/17/18
17:17
Syndicate
Breaking Syndicate news story on Smith Micro »

Smith Micro files to sell…

03/08/13
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NDRA

ENDRA Life Sciences

$2.70

0.2 (8.00%)

17:14
08/17/18
08/17
17:14
08/17/18
17:14
Syndicate
Breaking Syndicate news story on ENDRA Life Sciences »

ENDRA Life Sciences files…

03/08/13
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BA

Boeing

$346.44

0.55 (0.16%)

17:10
08/17/18
08/17
17:10
08/17/18
17:10
Hot Stocks
Boeing awarded $152.5M U.S. Navy contract »

Boeing is awarded a…

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BA

Boeing

$346.44

0.55 (0.16%)

17:09
08/17/18
08/17
17:09
08/17/18
17:09
Hot Stocks
Boeing awarded $217M Defense Department contract »

The Boeing Co has been…

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LLL

L3 Technologies

$210.37

0.56 (0.27%)

17:08
08/17/18
08/17
17:08
08/17/18
17:08
Hot Stocks
L3 Technologies awarded $240M Defense Department contract »

L-3 Communications was…

03/08/13
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HSGX

Histogenics

$2.65

-0.05 (-1.85%)

17:06
08/17/18
08/17
17:06
08/17/18
17:06
Syndicate
Breaking Syndicate news story on Histogenics »

Histogenics files $75M…

03/08/13
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PLD

Prologis

$67.45

1.79 (2.73%)

, DCT

DCT Industrial

$68.77

1.805 (2.70%)

16:58
08/17/18
08/17
16:58
08/17/18
16:58
Conference/Events
DCT Industrial to host special shareholder meeting »

Special Shareholder…

PLD

Prologis

$67.45

1.79 (2.73%)

DCT

DCT Industrial

$68.77

1.805 (2.70%)

03/08/13
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