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PTGX

Protagonist Therapeutics

$7.02

0.06 (0.86%)

07:10
08/06/18
08/06
07:10
08/06/18
07:10

Protagonist announces results from re-analysis fo Phase 2 Propel study

Protagonist Therapeutics announced results from an independent blinded re-analysis of the Phase 2 PROPEL study of oral alpha-4-beta-7 integrin antagonist PTG-100 for the treatment of patients with ulcerative colitis, UC. No safety concerns were noted with PTG-100. The data from blinded endoscopy re-reads and a comprehensive data review provide signals of clinical efficacy and support further development of PTG-100. In March Protagonist announced discontinuation of the study following a planned interim analysis conducted by an independent Data Monitoring Committee. The interim data revealed an unusually high placebo rate of clinical remission that led to a futility decision and discontinuation of the trial. A re-read of the endoscopies by the CRO's subcontractor and a subsequent fully blinded re-read of the endoscopies by an independent third party, Robarts Clinical Trials, confirmed that a subset of the initial endoscopy reads provided by the CRO were in error. If the re-read of endoscopy results had been utilized for the interim futility analysis, the trial would have continued. In addition, improvements observed in independent, blinded histological scores favor PTG-100 over placebo and correlate with the clinical remission and endoscopic response outcomes from the re-analysis.

PTGX Protagonist Therapeutics
$7.02

0.06 (0.86%)

06/06/18
LEHM
06/06/18
DOWNGRADE
Target $8.5
LEHM
Equal Weight
Protagonist downgraded to Equal Weight from Overweight at Barclays
Barclays analyst Douglas Tsao downgraded Protagonist Therapeutics to Equal Weight and lowered his price target for the shares to $8.50 from $30. The analyst continues to see value in the company's pipeline assets, but does expect achievement of key catalysts until the second half of 2019. As such, the analyst sees greater near-term potential in small cap names with catalysts upcoming, such as Foamix (FOMX).
03/27/18
BMOC
03/27/18
NO CHANGE
Target $13
BMOC
Outperform
Protagonist Therapeutics price target lowered to $13 from $42 at BMO Capital
BMO Capital analyst M. Ian Somaiya slashed his price target on Protagonist Therapeutics (PTGX) to $13 following the announcement that the company is discontinuing its Phase 2b study of PTG-100 in patients with moderate to severe ulcerative colitis. Somaiya adds that his valuation is now driven by the risk-adjusted sales model for PTG-200, which "represents a higher probability clinical program with peak sales of over $2B". The analyst also notes that he continues to exclude the clinical data of PTG-300 from his model. Despite the steep price target revision, Somaiya keeps his Outperform rating and recommends that investors buy into the weakness after the PTG-100 clinical disappointment on anticipated PTG-200 data and the advancement of Johnson&Johnson (JNJ) - shared Stelara.
03/26/18
STFL
03/26/18
DOWNGRADE
Target $11
STFL
Hold
Protagonist Therapeutics downgraded to Hold from Buy at Stifel
Stifel analyst Adam Walsh downgraded Protagonist Therapeutics to Hold and cut his price target for the shares to $11 from $32. The downgrade follows news that the company is discontinuing its Phase 2b study of PTG-100 in patients with moderate to severe ulcerative colitis.
01/29/18
STFL
01/29/18
INITIATION
Target $32
STFL
Buy
Protagonist Therapeutics initiated with a Buy at Stifel
Stifel analyst Adam Walsh started Protagonist Therapeutics with a Buy rating and $32 price target, saying he sees a relatively low hurdle for success for its near-term interim Phase 2b results for PTG-100 in moderate-to-severe ulcerative colitis. Protagonist appears poised for upside given the company's three unique pipeline assets in the clinic targeting market opportunities of over $1B, added Walsh.

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