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SPPI

Spectrum

$21.04

-0.33 (-1.54%)

11:44
09/24/18
09/24
11:44
09/24/18
11:44

Spectrum announces preliminary poziotinib data from Phase 2 study

Spectrum Pharmaceuticals announced preliminary poziotinib data from the University of Texas, MD Anderson Cancer Center Phase 2 non-small cell lung cancer study which were released during an oral presentation at the IASLC 19th World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer. The MD Anderson study is the single largest data set of patients with an exon 20 mutation in EGFR or HER2. In the interim analysis presented at the WCLC, the following observations were made: This phase II study demonstrates high anti-tumor activity for poziotinib in metastatic, heavily pretreated EGFR exon 20 mutant NSCLC, a group for which no targeted agents have proven effective to date with best response of PR in 55% of evaluable patients. Median PFS 5.5m; durable responses observed with 6 treated for greater than1year thus far. Compares favorably to historical ORR rates of less than8% approved TKIs and less than19% for standard of care 2L agents. Significant activity also observed in HER2 exon 20-mutant NSCLC with initial responses observed in 50% evaluable patients and median PFS 5.1m. EGFR-related toxicities were manageable and required dose reductions in 60%. Discontinuation due to poor tolerance was rare. Encouraging activity has prompted a confirmatory, international, multicenter study in EGFR and HER2 exon 20 mutant NSCLC patients which is currently enrolling, including a first-line cohort, and development of a separate pan-tumor basket study. The poziotinib NSCLC clinical program for patients with EGFR or HER2 exon 20 insertion mutations currently consists of a Phase 2 investigator-initiated study at The University of Texas, MD Anderson Cancer Center and a Phase 2 pivotal, Spectrum-sponsored, multi-center, global study with active sites in the United States and future centers planned in Canada and Europe. The overall poziotinib clinical development program is focused on four pillars, including previously treated NSCLC, first-line treatment of NSCLC, combination therapy and treatment of other solid tumors.

  • 24

    Sep

  • 01

    Oct

SPPI Spectrum
$21.04

-0.33 (-1.54%)

09/06/18
JEFF
09/06/18
NO CHANGE
Target $25
JEFF
Buy
Spectrum should begin to retrace last week's selloff, says Jefferies
Jefferies analyst Matthew Andrews says the new interim poziotinib data from the MD Anderson Phase 2 non-small cell lung cancer study "don't disappoint." Shares of Spectrum Pharmaceuticals should begin to retrace the drop since last week amid concerns about the Korean poziotinib HER2 data, Andrews tells investors in a research note. The analyst believes the unconfirmed overall response rate of 58% in EGFR and 50% in HER2 are "impressive." He keeps a Buy rating on Spectrum with a $25 price target.
09/06/18
HCWC
09/06/18
NO CHANGE
Target $40
HCWC
Buy
Spectrum price target raised to $40 from $34 at H.C. Wainwright
H.C. Wainwright analyst Edward White raised his price target for Spectrum Pharmaceuticals to $40 after the company presented at his firm's conference. The analyst remains optimistic about both the stock and the company's pipeline, which he notes includes poziotinib in non-small cell lung cancer and HER2-positive breast cancer and Rolontis in chemotherapy-induced neutropenia. Progress is being made across developmental programs along with upcoming catalysts, White tells investors in a research note. He keeps a Buy rating on Spectrum.
08/31/18
RILY
08/31/18
NO CHANGE
Target $35
RILY
Buy
Spectrum price target raised to $35 from $26 at B. Riley FBR
B. Riley FBR analyst David Buck raised his price target for Spectrum Pharmaceuticals to $36 and keeps a Buy rating on the shares ahead of the company's September 5 data abstract.
06/27/18
RILY
06/27/18
NO CHANGE
Target $26
RILY
Buy
Spectrum takeover report 'plausible,' says B. Riley FBR
Following a report from Bloomberg yesterday that Spectrum Pharmaceuticals is exploring options including a sale of the business amid takeover interest from other drugmakers, B. RIley FBR analyst David Buck told investors in a research note that while he has no confirmation of any takeover interest or sale process, he sees the report as "plausible." Buck, who reiterated a Buy rating, says that he continues to see his $26 per share target based on DCF and 2022E earnings power as "reasonable." Aide from any actual news on a potential transaction or sales process that gets confirmed, he expects further news flow on pipeline drug Rolontis, including a June 29 Spectrum-sponsored conference call and an expected presentation of additional poziotinib data at the World Lung Conference.

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AMZN

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ICE

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AMD

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MCHP

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MU

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NVDA

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AMGN

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1.6 (0.86%)

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PGNX

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WES

Western Gas Partners

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PXD

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ZTS

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JNJ

Johnson & Johnson

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WIN

Windstream

$3.37

0.2 (6.31%)

, UNIT

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$3.37

0.2 (6.31%)

UNIT

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BHVN

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AMGN

Amgen

$188.31

1.6 (0.86%)

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CE

Celanese

$100.19

1.19 (1.20%)

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WIN

Windstream

$3.37

0.2 (6.31%)

, UNIT

Uniti Group

$20.00

0.53 (2.72%)

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$3.37

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UNIT

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GLD

SPDR Gold Shares

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MDLZ

Mondelez

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FN

Fabrinet

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0.67 (1.23%)

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UBER

Uber

$0.00

(0.00%)

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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$277.40

2.93 (1.07%)

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S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$277.40

2.93 (1.07%)

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ORCL

Oracle

$51.71

0.25 (0.49%)

17:11
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