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LLY

Eli Lilly

$108.59

0.63 (0.58%)

06:36
10/04/18
10/04
06:36
10/04/18
06:36

Boehringer Ingelheim, Eli Lilly announce empagliflozin meets primary endpoint

Boehringer Ingelheim and Eli Lilly announced that empagliflozin met the primary efficacy endpoint, defined as a change from baseline in A1C versus placebo after 26 weeks of treatment, for all doses investigated in the Empagliflozin as Adjunctive to inSulin thErapy, or EASE, Phase III program in adults with type 1 diabetes. The EASE program results were published online in Diabetes Care ahead of print and presented at the 54th EASD Annual Congress. Empagliflozin is currently not approved for use in type 1 diabetes. The EASE-2 study evaluated doses of 10 and 25 mg of empagliflozin as an adjunct to insulin over 52 weeks, while the EASE-3 study evaluated doses of 2.5, 10, and 25 mg of empagliflozin as an adjunct to insulin over 26 weeks. In EASE-2, placebo-corrected mean change from baseline in A1C at week 26 was -0.54% and -0.53% for empagliflozin 10 and 25 mg, respectively. In EASE-3, placebo-corrected mean change from baseline in A1C at week 26 was -0.28%, -0.45% and -0.52% for empagliflozin 2.5 mg, 10 mg and 25 mg, respectively. In addition to reduction in A1C, empagliflozin treatment was effective on secondary endpoints, showing reductions in weight, decreases in blood pressure, and decreases in total daily insulin dose. In addition, data from continuous glucose monitoring in the EASE program indicates that patients treated with empagliflozin had improved glycemic variability and spent more time in range, although the data for the 2.5 mg dose are limited.There was no increase in the risk of investigator-reported hypoglycemic events, including severe hypoglycemia, with empagliflozin treatment, which was a key secondary endpoint in the trials. Additionally, a reduction in patient-reported hypoglycemic events was observed. The number of adjudicated diabetic ketoacidosis, or DKA, events was comparable between empagliflozin 2.5 mg and placebo, and higher than placebo with empagliflozin 10 and 25 mg. Apart from incidence of DKA, the safety profile observed in the EASE program was generally consistent with the previously reported safety profile of empagliflozin in adults with type 2 diabetes. Based on the totality of the EASE data, Boehringer Ingelheim has initiated regulatory discussions for empagliflozin as adjunct to insulin for adults with type 1 diabetes.

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LLY Eli Lilly
$108.59

0.63 (0.58%)

10/03/18
BMOC
10/03/18
NO CHANGE
Target $107
BMOC
Market Perform
Eli Lilly price target raised to $107 from $90 at BMO Capital
BMO Capital analyst Alex Arfaei raised his price target on Eli Lilly to $107 to reflect the recent run-up in the stock price, though he says he would not recommend "chasing it" at current price level. The analyst cites the company's "solid commercial execution" and unlocked value of Elanco divestiture, adding that its upcoming LY'176 data at EASD should strengthen its long-term growth prospects in the GLP-1 market. Arfaei keeps his Market Perform rating on Eli Lilly, adding that the stock looks "fairly valued" with underappreciated risks around insulins and opportunities around (Tanezumab, GIP/GLP-1, migraine and Alzheimer's franchises.
10/01/18
RHCO
10/01/18
NO CHANGE
Target $123
RHCO
Buy
Eli Lilly price target raised to $123 from $105 at SunTrust
SunTrust analyst John Boris raised his price target on Eli Lilly to $123 after meeting with its management and investors, saying the discussions highlighted the company's "solid execution" and diversified volume-driven pipeline growth. The analyst cites the company's "new indications or line extension" - NILEX - opportunities, pointing to diabetes gains from Trulicity, immunology label expansion for Taltz, and another leg of growth in its pain drugs. Boris keeps his Buy rating on Eli Lilly and believes that it is "positioned to drive earnings growth faster than sales, as gross margin and fixed cost leverage yield operating margin expansion".
10/01/18
GSCO
10/01/18
UPGRADE
Target $30
GSCO
Conviction Buy
Teva upgraded to Conviction Buy from Buy at Goldman Sachs
Goldman Sachs analyst Jami Rubin added Teva Pharmaceuticals (TEVA) to Goldman's Conviction List with a Buy rating. The analyst calls the recent selloff in the shares a "head scratcher" and sees a buying opportunity at current levels. Recent concerns raised in the marketplace regarding second half of 2018 headwinds and Eli Lilly's (LLY) galcenuzemab approval were already expected and well understood, Rubin tells investors in a research note. The analyst sees "meaningful upside" in shares of Teva and has a $30 price target for the name.
09/28/18
WELS
09/28/18
NO CHANGE
WELS
Market Perform
Lilly's migraine treatment approval adds to Teva worries, says Wells Fargo
Wells Fargo analyst David Maris noted that Eli Lilly (LLY) received FDA approval of Emgality for the prevention of migraines and announced a U.S. list price of $6,900 annually, which is in line with Teva's (TEVA) Ajovy and Aimovig from Amgen (AMGN) and Novartis (NVS). Lilly's approval adds to Teva investor worries, said Maris, who sees migraines being a competitive market with similar drugs "where the competitors are marketing powerhouses...and Teva is undergoing a lot of organizational change." He maintains a Market Perform rating on Teva shares.

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