Breaking News Instant updates and real-time market news.

SRPT

Sarepta

$146.98

4.17 (2.92%)

06:50
10/04/18
10/04
06:50
10/04/18
06:50

Sarepta gene therapy showed functional improvements across all measures

Sarepta Therapeutics announced yesterday that at the 23rd International Congress of the World Muscle Society in Mendoza, Argentina, Jerry Mendell, M.D., of Nationwide Children's Hospital presented updated results from its gene therapy clinical trial assessing AAVrh74.MHCK7.micro-Dystrophin in individuals with Duchenne muscular dystrophy. Dr. Mendell presented the following updated data on the four patients enrolled in the study: All patients showed robust expression of transduced micro-dystrophin, which is properly localized to the muscle sarcolemma, as measured by immunohistochemistry. Mean gene expression for the study, as measured by percentage of micro-dystrophin positive fibers was 81.2% and the mean intensity of the fibers was 96.0% compared to normal control. All post-treatment biopsies showed robust levels of micro-dystrophin as measured by Western blot, with a mean of 74.3% compared to normal utilizing Sarepta's method, or 95.8% compared to normal pursuant to Nationwide Children's quantification of Sarepta's method that adjusts for fat and fibrotic tissue. Gene expression for the fourth patient was robust, as follows: As measured by immunohistochemistry, micro-dystrophin positive fibers was 96.2% and the mean intensity of the fibers was 160.0% compared to normal control. As measured by Western blot, patient 4 showed robust levels of micro-dystrophin, with a mean of 182.7% compared to normal utilizing Sarepta's method, or 222% compared to normal pursuant to Nationwide Children's quantification of Sarepta's method that adjusts for fat and fibrotic tissue. In all patients, expression of micro-dystrophin was associated with significant expression and up-regulation of the dystrophin-associated protein complex, an additional indication of functionality of dystrophin. All patients showed significant decreases of serum creatine kinase levels at last measure, with a mean reduction of CK of over 78% from baseline. Doug Ingram, Sarepta's president and CEO, said, "The encouraging results that we previously saw and reinforced in the fourth patient strengthen our resolve to rapidly move to a confirming trial and, assuming successful, to bring this therapy to the Duchenne community around the world with a sense of urgency."

SRPT Sarepta
$146.98

4.17 (2.92%)

10/03/18
JMPS
10/03/18
NO CHANGE
Target $270
JMPS
Outperform
JMP looking for continued dystrophin expression in Sarepta gene therapy update
JMP Securities analyst Liisa Bayko noted that Sarepta is scheduled to give an update on its Phase 1/2a study of a micro-dystrophin gene therapy at the World Muscle Society meeting and see hopes to see about 40% micro-dystrophin expression in the fourth patient and at least one vector copy per nucleus, which would be in line with the first three patients. She is also looking for details of the functional benefits that were previously acknowledged, said Bayko, who keeps an Outperform rating and $270 price target on Sarepta shares.
10/01/18
CANT
10/01/18
INITIATION
Target $217
CANT
Overweight
Sarepta initiated with an Overweight at Cantor Fitzgerald
Cantor Fitzgerald analyst Alethia Young started Sarepta Therapeutics with an Overweight rating and $217 price target.
09/26/18
RBCM
09/26/18
NO CHANGE
Target $200
RBCM
Outperform
Sarepta price target raised to $200 from $187 at RBC Capital
RBC Capital analyst Brian Abrahams raised his price target on Sarepta to $200 and kept his Outperform rating. The analyst says his discussions with the company's senior management have left him "even more impressed with their commercial and clinical execution, strong focus on maintaining competitive positioning in development and manufacturing, and commitment to cement their gene therapy leadership role". Abrahams also anticipates a "favorable supportive data" for the microdystrophin gene therapy program at next week's WMS event, with the pivotal plans for the program remaining on track toward FDA feedback later this year and dosing before year-end.
09/24/18
BTIG
09/24/18
NO CHANGE
Target $190
BTIG
Buy
Sarepta one step closer to gene therapy trial with FDA lifting hold, says BTIG
BTIG analyst Timothy Chiang said the FDA lifting its clinical hold on Sarepta's micro-dystrophin gene therapy program for the treatment of Duchenne Muscular Dystrophy moves the company one step closer to beginning its registrational study in 24 patients. The analyst, who expects additional biomarker data to be presented in early October on the four patients that have been dosed with its AAVrh74 micro-dystrophin gene therapy program, maintains a Buy rating and $190 price target on Sarepta shares.

TODAY'S FREE FLY STORIES

RGR

Sturm, Ruger

$41.48

0.69 (1.69%)

, AOBC

American Outdoor Brands

$7.69

-0.01 (-0.13%)

19:40
08/22/19
08/22
19:40
08/22/19
19:40
Hot Stocks
Trump 'hopeful' to work with Congress on' legislation addressing mass shootings »

President Donald Trump…

RGR

Sturm, Ruger

$41.48

0.69 (1.69%)

AOBC

American Outdoor Brands

$7.69

-0.01 (-0.13%)

VSTO

Vista Outdoor

$5.33

0.26 (5.13%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 29

    Aug

  • 10

    Sep

  • 19

    Sep

TOT

Total

$48.98

-0.18 (-0.37%)

19:16
08/22/19
08/22
19:16
08/22/19
19:16
Downgrade
Total rating change at Citi »

Total downgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

KMPR

Kemper

$75.42

0.48 (0.64%)

19:14
08/22/19
08/22
19:14
08/22/19
19:14
Downgrade
Kemper rating change at William Blair »

Kemper downgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 04

    Sep

  • 10

    Sep

  • 11

    Sep

CRM

Salesforce

$148.26

0.86 (0.58%)

, INTU

Intuit

$276.05

-0.29 (-0.10%)

18:52
08/22/19
08/22
18:52
08/22/19
18:52
Hot Stocks
Fly Intel: After Hours Movers »

UP AFTER EARNINGS: …

CRM

Salesforce

$148.26

0.86 (0.58%)

INTU

Intuit

$276.05

-0.29 (-0.10%)

PVTL

Pivotal Software

$13.69

0.01 (0.07%)

CBLK

Carbon Black

$24.52

1.77 (7.78%)

HPQ

HP Inc.

$18.91

-0.04 (-0.21%)

RAVN

Raven

$31.36

-0.87 (-2.70%)

VMW

VMware

$148.15

0.11 (0.07%)

ROST

Ross Stores

$107.31

1.63 (1.54%)

GPS

Gap

$17.75

0.79 (4.66%)

HAS

Hasbro

$114.35

-1.06 (-0.92%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Aug

  • 22

    Aug

  • 22

    Aug

  • 22

    Aug

  • 22

    Aug

  • 22

    Aug

  • 22

    Aug

  • 28

    Aug

  • 28

    Aug

  • 04

    Sep

  • 10

    Sep

  • 25

    Sep

  • 10

    Oct

  • 27

    Oct

  • 12

    Dec

  • 16

    Dec

TLND

Talend

$39.24

0.12 (0.31%)

18:45
08/22/19
08/22
18:45
08/22/19
18:45
Hot Stocks
Talend CEO: We solve the first mile in the data journey »

In an interview on…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

BA

Boeing

$354.47

14.44 (4.25%)

18:40
08/22/19
08/22
18:40
08/22/19
18:40
Periodicals
FAA intends to test Boeing MAX software on newer pilots, Reuters says »

Next month, the FAA…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 03

    Sep

DB

Deutsche Bank

$7.17

0.155 (2.21%)

18:32
08/22/19
08/22
18:32
08/22/19
18:32
Periodicals
Deutsche Bank to pay $16M to settle corruption charges with SEC, Reuters says »

The SEC said that…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$292.36

-0.04 (-0.01%)

18:28
08/22/19
08/22
18:28
08/22/19
18:28
Periodicals
Kudlow says U.S., Chinese negotiators held productive trade talks, Reuters says »

White House economic…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$292.36

-0.04 (-0.01%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

GOOG

Alphabet

$1,188.53

-2.26 (-0.19%)

, GOOGL

Alphabet Class A

$1,190.41

0.15 (0.01%)

18:25
08/22/19
08/22
18:25
08/22/19
18:25
Hot Stocks
Google disabled 210 YouTube channels related to ongoing Hong Kong protests »

Google (GOOG) said in a…

GOOG

Alphabet

$1,188.53

-2.26 (-0.19%)

GOOGL

Alphabet Class A

$1,190.41

0.15 (0.01%)

FB

Facebook

$182.08

-1.48 (-0.81%)

TWTR

Twitter

$42.17

-0.63 (-1.47%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Sep

  • 24

    Sep

  • 27

    Oct

NUAN

Nuance

$17.31

-0.14 (-0.80%)

18:24
08/22/19
08/22
18:24
08/22/19
18:24
Syndicate
Nuance files Form 10 registration statement for planned spin-off of Cerence »

Nuance Communications…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

CRM

Salesforce

$148.26

0.86 (0.58%)

18:23
08/22/19
08/22
18:23
08/22/19
18:23
Hot Stocks
Salesforce co-CEO: We had a very strong second quarter »

In an interview on…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Aug

  • 28

    Aug

  • 28

    Aug

  • 12

    Dec

  • 16

    Dec

RVLT

Revolution Lighting

$0.34

-0.0124 (-3.57%)

18:10
08/22/19
08/22
18:10
08/22/19
18:10
Hot Stocks
Revolution Lighting discloses additional delisting determination from Nasdaq »

Revolution Lighting…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

IBKC

Iberiabank

$70.16

-0.38 (-0.54%)

18:05
08/22/19
08/22
18:05
08/22/19
18:05
Hot Stocks
Iberiabank CEO Daryl Byrd sells over $840K in company shares »

Iberiabank CEO Daryl Byrd…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Sep

RMNI

Rimini Street

$4.77

-0.11 (-2.25%)

, ORCL

Oracle

$53.18

-0.08 (-0.15%)

18:02
08/22/19
08/22
18:02
08/22/19
18:02
Hot Stocks
San Fang Chemical switches to Rimini Street support for Oracle EBS »

Rimini Street (RMNI)…

RMNI

Rimini Street

$4.77

-0.11 (-2.25%)

ORCL

Oracle

$53.18

-0.08 (-0.15%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

CRM

Salesforce

$148.26

0.86 (0.58%)

18:01
08/22/19
08/22
18:01
08/22/19
18:01
Hot Stocks
Salesforce says Customer 360 will be huge growth driver over next decade »

Says: Momentum in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Aug

  • 28

    Aug

  • 28

    Aug

  • 12

    Dec

  • 16

    Dec

AAC

AAC Holdings

$0.60

-0.0327 (-5.17%)

17:57
08/22/19
08/22
17:57
08/22/19
17:57
Hot Stocks
AAC Holdings discloses NYSE listing notice »

AAC Holdings announced…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Sep

17:32
08/22/19
08/22
17:32
08/22/19
17:32
General news
Fed Balance Sheet Level data reported »

Week of 8/21 Fed Balance…

HPQ

HP Inc.

$18.91

-0.04 (-0.21%)

17:30
08/22/19
08/22
17:30
08/22/19
17:30
Hot Stocks
HP Inc. says notebooks accounted for 39% of revenue in Q3 »

Says supplies category…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Aug

  • 10

    Sep

17:28
08/22/19
08/22
17:28
08/22/19
17:28
General news
Money Supply M2 Weekly Change data reported »

Week of 8/12 Money Supply…

TRPX

Therapix Biosciences

$2.35

(0.00%)

17:27
08/22/19
08/22
17:27
08/22/19
17:27
Syndicate
Breaking Syndicate news story on Therapix Biosciences »

Therapix Biosciences…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

GLD

SPDR Gold Shares

$141.38

-0.36 (-0.25%)

17:26
08/22/19
08/22
17:26
08/22/19
17:26
Hot Stocks
SPDR Gold Shares holdings rise to 854.84MT to 851.91MT »

This is the third…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

VMW

VMware

$148.15

0.11 (0.07%)

17:19
08/22/19
08/22
17:19
08/22/19
17:19
Earnings
VMware sees Q3 adjusted EPS $1.42, consensus $1.57 »

Sees Q3 revenue growth…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Aug

  • 10

    Sep

  • 10

    Oct

CRWD

Crowdstrike

$93.04

-3.5 (-3.63%)

, CBLK

Carbon Black

$24.52

1.77 (7.78%)

17:14
08/22/19
08/22
17:14
08/22/19
17:14
Hot Stocks
Crowdstrike lower after Carbon Black acquisition »

Shares of cybersecurity…

CRWD

Crowdstrike

$93.04

-3.5 (-3.63%)

CBLK

Carbon Black

$24.52

1.77 (7.78%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 05

    Sep

HPQ

HP Inc.

$18.91

-0.04 (-0.21%)

17:07
08/22/19
08/22
17:07
08/22/19
17:07
Hot Stocks
HP Inc. says CEO Dion Weisler will step down to deal with family health matter »

Says Enrique Lores, the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Aug

  • 10

    Sep

NP

Neenah Paper

$66.14

-0.455 (-0.68%)

17:05
08/22/19
08/22
17:05
08/22/19
17:05
Hot Stocks
Neenah Paper CFO sells 7.8K shares of common stock »

In a regulatory filing,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.