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LOXO

Loxo Oncology

$159.49

-3.01 (-1.85%)

, BPMC

Blueprint Medicines

$69.58

-1.63 (-2.29%)

18:12
10/07/18
10/07
18:12
10/07/18
18:12

Loxo Oncology's 292 remains on top after RET data updates, says Piper Jaffray

Piper Jaffray analyst Tyler Van Buren reiterates an Overweight rating and $200 price target for Loxo Oncology (LOXO) after the company provided an update of the thyroid patients in the Phase I/II study of LOXO-292. The analyst highlights that in the largest patient population the response rate increased from 45% to 59% with three additional patients responding between 9 and 12 months. Blueprint Medicines' (BPMC) competing BLU-667 reported a 49% ORR in a similar patient population and recall that adverse events of hypertension are still a concern, he notes. Van Buren believes that the 667's safety profile could continue to look worse as it continues to administer the drug to patients at higher doses and that treatment discontinuations could increase. Overall, the analyst believes Loxo's 292 appears to be the superior RET inhibitor in development, both in terms of efficacy and safety and could easily become a $1B+ drug.

LOXO

Loxo Oncology

$159.49

-3.01 (-1.85%)

BPMC

Blueprint Medicines

$69.58

-1.63 (-2.29%)

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    Oct

  • 08

    Nov

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    Nov

  • 27

    Nov

LOXO Loxo Oncology
$159.49

-3.01 (-1.85%)

09/17/18
GUGG
09/17/18
INITIATION
Target $184
GUGG
Neutral
Loxo Oncology initiated with a Neutral at Guggenheim
Target $184.
09/24/18
LEER
09/24/18
INITIATION
Target $205
LEER
Outperform
Loxo Oncology initiated with an Outperform at Leerink
Leerink analyst Andrew Berens started Loxo Oncology with an Outperform rating and $205 price target.
09/26/18
PIPR
09/26/18
NO CHANGE
Target $200
PIPR
Overweight
Loxo RET inhibitor still looks superior to Blueprint's, says Piper Jaffray
Loxo Oncology (LOXO) provided an update of the Phase I/II Libretto study of LOXO-292, the company's RET inhibitor and the vast majority of the current valuation, Piper Jaffray analyst Tyler Van Buren tells investors in a research note. While the overall response rate dropped slightly from 77% to 68% in more patients, it still appears superior to Blueprint Medicines' (BPMC) competing BLU-667, which has thus far demonstrated a 47% response rate in a similar patient population, the analyst contends. Van Buren adds that he's unconcerned by the two new grade three adverse events reported. He believes there "may very well" be upside to his current $1.5B peak sales estimate by the mid-2020s. The analyst reiterates an Overweight rating on Loxo Oncology with a $200 price target.
09/26/18
STFL
09/26/18
NO CHANGE
Target $217
STFL
Buy
Loxo data not 'transformational,' but keeps inspiring confidence, says Stifel
Stifel analyst Stephen Willey said the incremental follow-up data from Loxo Oncology's (LOXO) LIBRETTO-001 trial isn't "transformational," but it does confirm his confidence in the establishment of a high competitive hurdle for LOXO-292, which he sees being a "best-in-class" and first-to-market asset in a $1B+ market. He remains confident LOXO-292 is the superior asset, but acknowledges the anticipation of Blueprint Medicines' (BPMC) updated BLU-667 data at some point in late-FY18 to early-FY19 could serve as a bit of headwind on Loxo shares nearer to that data release. Willey keeps a Buy rating and $217 price target on Loxo shares.
BPMC Blueprint Medicines
$69.58

-1.63 (-2.29%)

09/19/18
PIPR
09/19/18
NO CHANGE
Target $50
PIPR
Overweight
Piper recommends Deciphera into systemic mastocytosis data
Piper Jaffray analyst Christopher Raymond keeps an Overweight rating on shares of Deciphera Pharmaceuticals (DCPH) with a $50 price target following a deep dive into the systemic mastocytosis treatment space and the potential for DCC-2618 to play a meaningful role in the disease. The analyst continues to recommend purchase of Deciphera into the systemic mastocytosis data for DCC-2618 early next year. Given what's been presented before between Novartis' (NVS) midostaurin and Blueprint Medicines' (BPMC) avapritinib, Raymond thinks an overall response rate of greater than 50% with a continued clean safety profile should be considered a win for DCC-2618. He models for DCC-2618 systemic mastocytosis revenue of $44M, $151M, and $290M for 2023 through 2025, respectively. The analyst remains a buyer of Deciphera shares into the Q1 of 2019 data.
09/24/18
LEER
09/24/18
INITIATION
Target $105
LEER
Outperform
Blueprint Medicines initiated with an Outperform at Leerink
Leerink analyst Andrew Berens started Blueprint Medicines with an Outperform rating and $105 price target.

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CSBR

Champions Oncology

$12.10

-0.61 (-4.80%)

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SCG

Scana

$36.09

-4.8 (-11.74%)

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$73.39

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$36.09

-4.8 (-11.74%)

D

Dominion

$73.39

-0.135 (-0.18%)

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SCG

Scana

$36.43

-4.46 (-10.91%)

, D

Dominion

$73.29

-0.235 (-0.32%)

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SCG

Scana

$36.43

-4.46 (-10.91%)

D

Dominion

$73.29

-0.235 (-0.32%)

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SYMC

Symantec

$19.73

0.06 (0.31%)

14:50
10/22/18
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14:50
Options
Sweep buyer of Symantec call options »

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AMTD

TD Ameritrade

$50.05

-0.44 (-0.87%)

14:49
10/22/18
10/22
14:49
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14:49
Options
TD Ameritrade options imply 5.8% move in share price post-earnings, above median historical move »

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MRBK

Meridian Bank

$17.01

(0.00%)

14:42
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14:42
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Meridian Bank names Randy J. McGarry chief information officer »

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KKR

KKR

$24.01

-0.21 (-0.87%)

14:35
10/22/18
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Options
KKR put volume heavy and directionally bearish »

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  • 25

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AU

AngloGold

$9.86

0.05 (0.51%)

14:34
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AngloGold says Kibali Gold Mine seen delivering record performance in Q3 »

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FB

Facebook

$155.28

1.33 (0.86%)

, SNAP

Snap

$6.79

-0.03 (-0.44%)

14:32
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OnTheFly
Piper's teen survey bodes well for Instagram, Prime as Apple remains dominant »

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FB

Facebook

$155.28

1.33 (0.86%)

SNAP

Snap

$6.79

-0.03 (-0.44%)

AAPL

Apple

$220.90

1.62 (0.74%)

AMZN

Amazon.com

$1,784.13

20.22 (1.15%)

WMT

Walmart

$97.13

-0.02 (-0.02%)

SSNLF

Samsung

$0.00

(0.00%)

ATVI

Activision Blizzard

$69.71

-0.04 (-0.06%)

EA

Electronic Arts

$102.05

-0.02 (-0.02%)

TTWO

Take-Two

$120.88

-1.62 (-1.32%)

GOOG

Alphabet

$1,103.00

6.59 (0.60%)

GOOGL

Alphabet Class A

$1,112.00

7.34 (0.66%)

ZNGA

Zynga

$4.02

0.01 (0.25%)

GLUU

Glu Mobile

$5.94

0.09 (1.54%)

VFC

VF Corp.

$77.53

-0.21 (-0.27%)

ADDYY

Adidas

$0.00

(0.00%)

LULU

Lululemon

$139.75

2.99 (2.19%)

CROX

Crocs

$19.81

1.32 (7.14%)

SBUX

Starbucks

$58.85

0.22 (0.38%)

CMG

Chipotle

$430.22

1.13 (0.26%)

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    Mar

FLXN

Flexion

$16.03

-2.93 (-15.45%)

14:29
10/22/18
10/22
14:29
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14:29
Recommendations
Flexion analyst commentary  »

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EEM

iShares MSCI Emerging Markets ETF

$40.06

0.37 (0.93%)

14:25
10/22/18
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Technical Analysis
Technical Take: iShares MSCI Emerging Markets ETF has active bullish pattern »

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PENN

Penn National

$27.02

-1.14 (-4.05%)

14:25
10/22/18
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Options
Penn National call volume above normal and directionally bullish »

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  • 01

    Nov

MCD

McDonald's

$166.85

-0.6 (-0.36%)

14:24
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Earnings
Fly Intel: What to watch in McDonald's earnings report »

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  • 23

    Oct

STZ

Constellation Brands

$221.76

-1.22 (-0.55%)

, STZ.B

Constellation Brands; also tag STZ

$225.00

-3.45 (-1.51%)

14:22
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Periodicals
Constellation Brands looks to sell some U.S. wine brands, Reuters says »

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STZ

Constellation Brands

$221.76

-1.22 (-0.55%)

STZ.B

Constellation Brands; also tag STZ

$225.00

-3.45 (-1.51%)

03/08/13
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  • 28

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BLMN

Bloomin' Brands

$19.85

0.28 (1.43%)

14:20
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Bloomin' Brands says has had seven discussions with Barington since March 2017 »

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  • 29

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

14:17
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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

14:16
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NYSE market internals summary »

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STZ

Constellation Brands

$221.31

-1.67 (-0.75%)

, STZ.B

Constellation Brands; also tag STZ

$225.00

-3.45 (-1.51%)

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Constellation Brands

$221.31

-1.67 (-0.75%)

STZ.B

Constellation Brands; also tag STZ

$225.00

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  • 28

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YNDX

Yandex

$27.71

0.29 (1.06%)

, GOOG

Alphabet

$1,102.24

5.83 (0.53%)

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GOOG

Alphabet

$1,102.24

5.83 (0.53%)

GOOGL

Alphabet Class A

$1,111.16

6.5 (0.59%)

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DB

Deutsche Bank

$10.74

-0.185 (-1.69%)

14:05
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Options
Deutsche Bank call volume above normal and directionally bullish »

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F

Ford

$8.44

0.085 (1.02%)

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Ford expanding test of autonomous vehicles to Washington, D.C. »

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  • 24

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    Dec

ZION

Zions Bancorp

$45.92

-1.05 (-2.24%)

13:55
10/22/18
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Options
Zions Bancorp put volume heavy and directionally bearish »

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  • 22

    Oct

BHGE

Baker Hughes

$29.68

-0.25 (-0.84%)

13:45
10/22/18
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Options
Baker Hughes call volume above normal and directionally bullish »

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  • 30

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