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LOXO

Loxo Oncology

$159.49

-3.01 (-1.85%)

, BPMC

Blueprint Medicines

$69.58

-1.63 (-2.29%)

18:12
10/07/18
10/07
18:12
10/07/18
18:12

Loxo Oncology's 292 remains on top after RET data updates, says Piper Jaffray

Piper Jaffray analyst Tyler Van Buren reiterates an Overweight rating and $200 price target for Loxo Oncology (LOXO) after the company provided an update of the thyroid patients in the Phase I/II study of LOXO-292. The analyst highlights that in the largest patient population the response rate increased from 45% to 59% with three additional patients responding between 9 and 12 months. Blueprint Medicines' (BPMC) competing BLU-667 reported a 49% ORR in a similar patient population and recall that adverse events of hypertension are still a concern, he notes. Van Buren believes that the 667's safety profile could continue to look worse as it continues to administer the drug to patients at higher doses and that treatment discontinuations could increase. Overall, the analyst believes Loxo's 292 appears to be the superior RET inhibitor in development, both in terms of efficacy and safety and could easily become a $1B+ drug.

LOXO

Loxo Oncology

$159.49

-3.01 (-1.85%)

BPMC

Blueprint Medicines

$69.58

-1.63 (-2.29%)

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LOXO Loxo Oncology
$159.49

-3.01 (-1.85%)

09/17/18
GUGG
09/17/18
INITIATION
Target $184
GUGG
Neutral
Loxo Oncology initiated with a Neutral at Guggenheim
Target $184.
09/24/18
LEER
09/24/18
INITIATION
Target $205
LEER
Outperform
Loxo Oncology initiated with an Outperform at Leerink
Leerink analyst Andrew Berens started Loxo Oncology with an Outperform rating and $205 price target.
09/26/18
PIPR
09/26/18
NO CHANGE
Target $200
PIPR
Overweight
Loxo RET inhibitor still looks superior to Blueprint's, says Piper Jaffray
Loxo Oncology (LOXO) provided an update of the Phase I/II Libretto study of LOXO-292, the company's RET inhibitor and the vast majority of the current valuation, Piper Jaffray analyst Tyler Van Buren tells investors in a research note. While the overall response rate dropped slightly from 77% to 68% in more patients, it still appears superior to Blueprint Medicines' (BPMC) competing BLU-667, which has thus far demonstrated a 47% response rate in a similar patient population, the analyst contends. Van Buren adds that he's unconcerned by the two new grade three adverse events reported. He believes there "may very well" be upside to his current $1.5B peak sales estimate by the mid-2020s. The analyst reiterates an Overweight rating on Loxo Oncology with a $200 price target.
09/26/18
STFL
09/26/18
NO CHANGE
Target $217
STFL
Buy
Loxo data not 'transformational,' but keeps inspiring confidence, says Stifel
Stifel analyst Stephen Willey said the incremental follow-up data from Loxo Oncology's (LOXO) LIBRETTO-001 trial isn't "transformational," but it does confirm his confidence in the establishment of a high competitive hurdle for LOXO-292, which he sees being a "best-in-class" and first-to-market asset in a $1B+ market. He remains confident LOXO-292 is the superior asset, but acknowledges the anticipation of Blueprint Medicines' (BPMC) updated BLU-667 data at some point in late-FY18 to early-FY19 could serve as a bit of headwind on Loxo shares nearer to that data release. Willey keeps a Buy rating and $217 price target on Loxo shares.
BPMC Blueprint Medicines
$69.58

-1.63 (-2.29%)

09/19/18
PIPR
09/19/18
NO CHANGE
Target $50
PIPR
Overweight
Piper recommends Deciphera into systemic mastocytosis data
Piper Jaffray analyst Christopher Raymond keeps an Overweight rating on shares of Deciphera Pharmaceuticals (DCPH) with a $50 price target following a deep dive into the systemic mastocytosis treatment space and the potential for DCC-2618 to play a meaningful role in the disease. The analyst continues to recommend purchase of Deciphera into the systemic mastocytosis data for DCC-2618 early next year. Given what's been presented before between Novartis' (NVS) midostaurin and Blueprint Medicines' (BPMC) avapritinib, Raymond thinks an overall response rate of greater than 50% with a continued clean safety profile should be considered a win for DCC-2618. He models for DCC-2618 systemic mastocytosis revenue of $44M, $151M, and $290M for 2023 through 2025, respectively. The analyst remains a buyer of Deciphera shares into the Q1 of 2019 data.
09/24/18
LEER
09/24/18
INITIATION
Target $105
LEER
Outperform
Blueprint Medicines initiated with an Outperform at Leerink
Leerink analyst Andrew Berens started Blueprint Medicines with an Outperform rating and $105 price target.

TODAY'S FREE FLY STORIES

AN

AutoNation

$37.22

-1.15 (-3.00%)

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TSLA

Tesla

$294.60

3.42 (1.17%)

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Nissan

$0.00

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TSLA

Tesla

$294.60

3.42 (1.17%)

NSANY

Nissan

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FSFG

First Savings Financial Group

$51.33

0.22 (0.43%)

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First Savings Financial raises quarterly dividend to 16c per share from 15c »

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MSFT

Microsoft

$110.97

1.5 (1.37%)

17:31
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Periodicals
Employees demand Microsoft cancel $480M U.S. Army contract, Reuters says »

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ENT

Global Eagle

$2.66

(0.00%)

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Global Eagle to cut workforce by roughly 15% »

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NOC

Northrop Grumman

$288.84

2.54 (0.89%)

17:13
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Northrop Grumman exec Kalan sells 4,312 common shares »

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LYB

LyondellBasell

$89.14

0.63 (0.71%)

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TCCO

Technical Comm Corp

$2.76

0.17 (6.56%)

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Technical Comm Corp to submit plan to regain compliance with Nasdaq by March 4 »

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INFU

InfuSystem

$4.15

0.04 (0.97%)

17:01
02/22/19
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17:01
Hot Stocks
InfuSystem announces settlement of derivative lawsuit »

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KALU

Kaiser Aluminum

$108.22

-1.9 (-1.73%)

17:01
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Hot Stocks
Kaiser Aluminum names Neal West as new CFO »

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ALDR

Alder Biopharmaceuticals

$14.35

0.19 (1.34%)

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RF

Regions Financial

$16.24

-0.01 (-0.06%)

16:59
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Breaking Syndicate news story on Regions Financial »

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HL

Hecla Mining

$2.59

-0.145 (-5.31%)

16:58
02/22/19
02/22
16:58
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Syndicate
Breaking Syndicate news story on Hecla Mining »

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BMY

Bristol-Myers

$50.99

0.84 (1.68%)

, CELG

Celgene

$89.15

0.54 (0.61%)

16:52
02/22/19
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Hot Stocks
Bristol-Myers files proxy statement in connection with proposed Celgene merger »

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BMY

Bristol-Myers

$50.99

0.84 (1.68%)

CELG

Celgene

$89.15

0.54 (0.61%)

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TEN

Tenneco

$36.29

0.76 (2.14%)

16:48
02/22/19
02/22
16:48
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Earnings
Tenneco sees FY19 revenue growth up 4%-5%, consensus $4.65B »

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TEN

Tenneco

$36.29

0.76 (2.14%)

16:46
02/22/19
02/22
16:46
02/22/19
16:46
Earnings
Tenneco reports preliminary Q4 revenue $4.3B, consensus $4.3B »

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XRX

Xerox

$31.50

0.16 (0.51%)

16:44
02/22/19
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Conference/Events
Xerox management to meet with Loop Capital »

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TWTR

Twitter

$31.70

0.94 (3.06%)

16:38
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Hot Stocks
Twitter board member Evan Williams to step down at end of month »

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ALLY

Ally Financial

$26.95

-0.07 (-0.26%)

16:34
02/22/19
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Hot Stocks
Ally Financial CEO sells over 97,000 common shares »

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DAL

Delta Air Lines

$51.52

0.04 (0.08%)

16:33
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Hot Stocks
Delta Air Lines' West sells 36,000 common shares »

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REN

Resolute Energy

$31.61

0.09 (0.29%)

16:30
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Hot Stocks
Resolute Energy stockholders approve merger with Cimarex Energy »

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Options
Preliminary option volume of 18.8M today »

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ORI

Old Republic

$21.14

0.04 (0.19%)

16:22
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Old Republic raises quarterly dividend to 20c from 19.5c per share »

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VIX

Volatility Index S&P 500 Options

$0.00

(0.00%)

16:20
02/22/19
02/22
16:20
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16:20
Options
Closing CBOE SPX and VIX Index summary for February 22nd »

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