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TRVN

Trevena

$0.94

(0.00%)

07:57
10/12/18
10/12
07:57
10/12/18
07:57

Trevena price target lowered to $4 from $15 at JMP Securities

JMP Securities analyst Jason Butler said the mixed Advisory Committee vote on Trevena's application for oliceridine is likely to result in an approval delay, but he has not given up on the potential for issues raised by the panel to be addressed with label modifications and post-marketing studies. He now assume the company receiving a CRL as his base case scenario, which would result in an 18-month delay to approval. Butler, who cut his probability of approval for oliceridine to 70% from 90% and lowered his peak sales estimate, reduced his price target on Trevena shares to $4 from $15 but keeps an Outperform rating on the stock.

  • 02

    Nov

TRVN Trevena
$0.94

(0.00%)

03/08/18
HCWC
03/08/18
NO CHANGE
Target $7
HCWC
Buy
Trevena price target raised to $7 from $5 at H.C. Wainwright
H.C. Wainwright analyst Ed Arce raised his price target for Trevena to $7 amid the "countdown to critical near-term value inflection points." The analyst notes the FDA action date for Olinvo in moderate to severe acute pain is November 2, 2018. He reaffirms a Buy rating on the shares.
10/10/18
JEFF
10/10/18
DOWNGRADE
Target $1
JEFF
Hold
Trevena downgraded to Hold from Buy at Jefferies
Jefferies analyst Biren Amin downgraded Trevena to Hold and cut his price target for the shares to $1 from $10. The FDA has an unfavorable view on both efficacy and safety profile of the company's oliceridine versus morphine, Amin tells investors in a research following yesterday's briefing documents. More critically, the documents make clear that Trevena failed to heed critical FDA advice in its Phase III trial design, the analyst adds. He sees no clear path forward for oliceridine.
10/12/18
NEED
10/12/18
DOWNGRADE
NEED
Hold
Trevena downgraded to Hold from Buy at Needham
10/12/18
NEED
10/12/18
DOWNGRADE
NEED
Hold
Trevena downgraded to Hold at Needham on oliceridine recommendation
As reported earlier, Needham analyst Alan Carr downgraded Trevena to Hold after the FDA's Administration Anesthetic and Analgesic Drug Products Advisory Committee, or AADPAC, voted 7-8 against the approval of oliceridine use in acute pain management. The analyst notes that documents from the FDA released this week also showed some reluctance in the drug's overall profile, and combined with this latest AADPAC decision, render the approval of oliceridine as improbable. Carr adds that Trevena will likely face challenges obtaining financial resources to support commercial launch even if oliceridine was approved next month, noting that he now awaits the official FDA decision and discussion of development for Trevena's other pipeline programs.

TODAY'S FREE FLY STORIES

VAR

Varian Medical

$104.25

-1.575 (-1.49%)

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NTGN

Neon Therapeutics

$8.88

0.56 (6.73%)

14:30
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GTHX

G1 Therapeutics

$46.88

-0.07 (-0.15%)

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NCNA

NuCana

$18.90

1.9 (11.18%)

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LPTX

Leap Therapeutics

$6.44

-0.17 (-2.57%)

, MRK

Merck

$72.34

0.12 (0.17%)

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Leap Therapeutics

$6.44

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MRK

Merck

$72.34

0.12 (0.17%)

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INCY

Incyte

$66.09

1.66 (2.58%)

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LOXO

Loxo Oncology

$160.01

-7.58 (-4.52%)

, BAYRY

Bayer

$0.00

(0.00%)

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LOXO

Loxo Oncology

$160.01

-7.58 (-4.52%)

BAYRY

Bayer

$0.00

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LOXO

Loxo Oncology

$160.01

-7.58 (-4.52%)

, BAYRY

Bayer

$0.00

(0.00%)

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Loxo announces larotrectinib clinical update in patients with TRK fusion cancers »

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LOXO

Loxo Oncology

$160.01

-7.58 (-4.52%)

BAYRY

Bayer

$0.00

(0.00%)

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MRTX

Mirati Therapeutics

$40.04

-1.82 (-4.35%)

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RHHBY

Roche

$0.00

(0.00%)

13:39
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GILD

Gilead

$73.27

-0.9 (-1.21%)

, GLPG

Galapagos NV

$107.66

2.29 (2.17%)

13:34
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Gilead, Galapagos NV announced data from Phase 3 FINCH2 trial of filgotinib »

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GILD

Gilead

$73.27

-0.9 (-1.21%)

GLPG

Galapagos NV

$107.66

2.29 (2.17%)

03/08/13
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BLRX

BioLineRx

$0.98

-0.22 (-18.33%)

, MRK

Merck

$72.34

0.12 (0.17%)

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BioLineRx discloses additional data from Phase 2a COMBAT/KEYNOTE-202 study »

BioLineRx (BLRX)…

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BioLineRx

$0.98

-0.22 (-18.33%)

MRK

Merck

$72.34

0.12 (0.17%)

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ADAP

Adaptimmune

$10.79

-0.09 (-0.83%)

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Adaptimmune presents updated data from ongoing MAGE-A10, MAGE-A4 studies »

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RHHBY

Roche

$0.00

(0.00%)

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PFE

Pfizer

$44.50

0.48 (1.09%)

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MRK

Merck

$72.34

0.12 (0.17%)

12:52
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Merck presents early data for STING agonist in advanced solid tumors/lymphomas »

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  • 23

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DVAX

Dynavax

$10.90

-0.47 (-4.13%)

, MRK

Merck

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0.12 (0.17%)

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Dynavax's SD-101, Keytruda combo still shows 70% ORR in Advanced Melanoma »

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$10.90

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MRK

Merck

$72.34

0.12 (0.17%)

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EXEL

Exelixis

$16.27

-0.25 (-1.51%)

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AGEN

Agenus

$1.97

-0.025 (-1.26%)

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  • 07

    Nov

OMED

OncoMed

$2.47

-0.17 (-6.44%)

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OncoMed announces interim phase 1b results for Navicixizumab, Paclitaxel combo »

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IMGN

ImmunoGen

$7.44

-0.355 (-4.56%)

, MRK

Merck

$72.34

0.12 (0.17%)

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ImmunoGen presents initial data from FORWARD II expansion cohort »

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IMGN

ImmunoGen

$7.44

-0.355 (-4.56%)

MRK

Merck

$72.34

0.12 (0.17%)

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  • 23

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BMY

Bristol-Myers

$54.31

-1.7 (-3.04%)

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Opdivo, Yervoy combo shows promising results in advanced form of bladder cancer »

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  • 22

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MRK

Merck

$72.34

0.12 (0.17%)

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  • 23

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TSRO

Tesaro

$41.81

-1.19 (-2.77%)

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Tesaro presents Phase 1 GARNET data of TSR-042 in MSI-H endometrial cancer »

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  • 01

    Nov

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    Nov

UDR

UDR, Inc.

09:37
10/21/18
10/21
09:37
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09:37
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UDR, Inc. rating change at Evercore ISI »

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  • 30

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