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LOXO

Loxo Oncology

$164.30

4.83 (3.03%)

06:50
10/15/18
10/15
06:50
10/15/18
06:50

Loxo Oncology receives Breakthrough Therapy Designation from FDA for LOXO-292

Loxo Oncology announced that the U.S. FDA has granted Breakthrough Therapy Designation to LOXO-292, a selective RET inhibitor, for the treatment of patients with advanced RET fusion-positive thyroid cancer who require systemic therapy, have progressed following prior treatment and have no acceptable alternative treatment options. This designation supplements the two LOXO-292 Breakthrough Therapy Designations granted in September 2018. The Breakthrough Therapy Designation announced today was also based on data from the ongoing global Phase 1/2 LIBRETTO-001 clinical trial.

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LOXO Loxo Oncology
$164.30

4.83 (3.03%)

09/26/18
STFL
09/26/18
NO CHANGE
Target $217
STFL
Buy
Loxo data not 'transformational,' but keeps inspiring confidence, says Stifel
Stifel analyst Stephen Willey said the incremental follow-up data from Loxo Oncology's (LOXO) LIBRETTO-001 trial isn't "transformational," but it does confirm his confidence in the establishment of a high competitive hurdle for LOXO-292, which he sees being a "best-in-class" and first-to-market asset in a $1B+ market. He remains confident LOXO-292 is the superior asset, but acknowledges the anticipation of Blueprint Medicines' (BPMC) updated BLU-667 data at some point in late-FY18 to early-FY19 could serve as a bit of headwind on Loxo shares nearer to that data release. Willey keeps a Buy rating and $217 price target on Loxo shares.
10/07/18
PIPR
10/07/18
NO CHANGE
Target $200
PIPR
Overweight
Loxo Oncology's 292 remains on top after RET data updates, says Piper Jaffray
Piper Jaffray analyst Tyler Van Buren reiterates an Overweight rating and $200 price target for Loxo Oncology (LOXO) after the company provided an update of the thyroid patients in the Phase I/II study of LOXO-292. The analyst highlights that in the largest patient population the response rate increased from 45% to 59% with three additional patients responding between 9 and 12 months. Blueprint Medicines' (BPMC) competing BLU-667 reported a 49% ORR in a similar patient population and recall that adverse events of hypertension are still a concern, he notes. Van Buren believes that the 667's safety profile could continue to look worse as it continues to administer the drug to patients at higher doses and that treatment discontinuations could increase. Overall, the analyst believes Loxo's 292 appears to be the superior RET inhibitor in development, both in terms of efficacy and safety and could easily become a $1B+ drug.
10/08/18
IFSG
10/08/18
UPGRADE
IFSG
Outperform
Loxo Oncology upgraded to Outperform from Market Perform at IFS Securities
10/08/18
10/08/18
UPGRADE
Target $190

Outperform
Loxo Oncology upgraded to Outperform on LOXO-292 update at IFS Securities
As previously reported, IFS Securities analyst David Bouchey upgraded Loxo Oncology to Outperform from Market Perform, with $190 price target, after the company reported updated results from its Phase I/II trial for LOXO-292. The analyst believes the response rates for LOXO-292 continue to look "very strong," the safety data is "excellent" and early results show that these responses appear durable. So far, the drug has outperformed expectations, he adds.

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HPE

HP Enterprise

$15.93

-0.03 (-0.19%)

13:55
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13:55
Conference/Events
HP Enterprise to host analyst meeting »

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AXON

Axovant Sciences

$0.00

(0.00%)

13:53
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GGAL

Grupo Financiero

$12.75

0.4 (3.24%)

13:45
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Grupo Financiero call volume above normal and directionally bullish »

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SNAP

Snap

$13.27

-0.73 (-5.21%)

, FB

Facebook

$184.57

2.3 (1.26%)

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On The Fly
#SocialStocks: Snap earnings beat, Facebook CEO testifies about Libra »

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TWTR

Twitter

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GOOG

Alphabet

$1,253.59

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GOOGL

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$1,251.72

10.64 (0.86%)

AMZN

Amazon.com

$1,757.06

-9.01 (-0.51%)

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ALXN

Alexion

$105.87

6.645 (6.70%)

13:37
10/23/19
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Alexion analyst commentary  »

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Treasury Action: the market took the good auction results in stride »

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

13:17
10/23/19
10/23
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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

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NYSE market internals summary »

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GOOG

Alphabet

$1,254.75

11.97 (0.96%)

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Alphabet Class A

$1,252.88

11.8 (0.95%)

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$1,254.75

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CC

Chemours

$17.16

1.1 (6.85%)

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Options
Chemours call volume above normal and directionally bullish »

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T

AT&T

$37.80

-0.38 (-1.00%)

, NWS

News Corp

$14.23

0.03 (0.21%)

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NWS

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$14.23

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NWSA

News Corp.

$13.86

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FB

Facebook

$184.53

2.26 (1.24%)

AAPL

Apple

$242.41

2.44 (1.02%)

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F

Ford

$9.06

-0.005 (-0.06%)

, GM

General Motors

$36.14

-0.185 (-0.51%)

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Earnings
Fly Intel: What to watch in auto sector earnings reports »

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F

Ford

$9.06

-0.005 (-0.06%)

GM

General Motors

$36.14

-0.185 (-0.51%)

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HEXO

Hexo

$2.54

-0.05 (-1.93%)

12:45
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10/23
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12:45
Hot Stocks
Breaking Hot Stocks news story on Hexo 

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NLY

Annaly Capital

$8.94

0.05 (0.56%)

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Options
Annaly Capital call volume above normal and directionally bullish »

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INTC

Intel

$51.83

-0.175 (-0.34%)

, SFTBF

SoftBank

$0.00

(0.00%)

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Periodicals
Intel files suit against SoftBank's Fortress over patents, Reuters says »

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INTC

Intel

$51.83

-0.175 (-0.34%)

SFTBF

SoftBank

$0.00

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C

Citi

$72.11

0.03 (0.04%)

12:42
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Judge says Citi claim against Czech miner OKD is eligible, Reuters says »

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ALXN

Alexion

$105.68

6.46 (6.51%)

12:40
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Alexion analyst commentary  »

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SHI

Sinopec Shanghai

$28.18

-0.44 (-1.54%)

12:40
10/23/19
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Upgrade
Sinopec Shanghai rating change  »

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General news
FX Action: USD-JPY »

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SFTBF

SoftBank

$0.00

(0.00%)

, WE

We Company

$0.00

(0.00%)

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Periodicals
WeWork's Claure tells staff layoffs are in the works, Reuters says »

Marcelo Claure,…

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SoftBank

$0.00

(0.00%)

WE

We Company

$0.00

(0.00%)

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BMY

Bristol-Myers

$53.89

-0.55 (-1.01%)

, RHHBY

Roche

$0.00

(0.00%)

12:36
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Periodicals
Trump to nominate Stephen Hahn as FDA commissioner, WSJ reports »

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Bristol-Myers

$53.89

-0.55 (-1.01%)

RHHBY

Roche

$0.00

(0.00%)

NVS

Novartis

$86.51

-0.32 (-0.37%)

GSK

GlaxoSmithKline

$43.27

0.76 (1.79%)

AZN

AstraZeneca

$44.61

0.69 (1.57%)

SNY

Sanofi

$45.54

0.23 (0.51%)

PFE

Pfizer

$36.63

0.19 (0.52%)

MRK

Merck

$82.39

1.09 (1.34%)

LLY

Eli Lilly

$106.97

-3.03 (-2.75%)

JNJ

Johnson & Johnson

$130.13

0.95 (0.74%)

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HEXO

Hexo

$2.54

-0.05 (-1.93%)

12:32
10/23/19
10/23
12:32
10/23/19
12:32
Syndicate
Hexo announces C$70M private placement of convertible debentures »

Hexo Corp announced that…

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CRM

Salesforce

$145.02

2.75 (1.93%)

12:30
10/23/19
10/23
12:30
10/23/19
12:30
Options
Heavy delta short term call buyer in Salesforce »

Heavy delta short term…

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DYMEF

DionyMed Brands

$0.00

(0.00%)

12:29
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10/23
12:29
10/23/19
12:29
Hot Stocks
DionyMed Brands receives court application seeking to appoint receiver »

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