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AVDL

Avadel Pharmaceuticals

$4.37

-0.18 (-3.96%)

08:35
10/15/18
10/15
08:35
10/15/18
08:35

Avadel data shows increase in duration of FUSP with Noctiva

Avadel Pharmaceuticals presented data from two abstracts from Phase 3 clinical trials of NOCTIVA at the American Urogynecologic Society Annual Scientific Meeting, Pelvic Floor Disorder Week 2018 in Chicago, Illinois from October 9-13. These data show that patients treated with NOCTIVA Nasal Spray - the lowest effective dose of desmopressin - experienced an increase in both duration of first uninterrupted sleep period and percentage of nights with one or no nocturic voids, and NOCTIVA's safety profile was well-tolerated. These results show that NOCTIVA is an effective therapy in patients with nocturia due to nocturnal polyuria. The efficacy of NOCTIVA on FUSP and safety, as secondary endpoints, were evaluated in patients age 50 years and older with nocturia due to nocturnal polyuria in two Phase 3 randomized, double-blind pivotal studies. FUSP is defined as elapsed time from bedtime to first NOV or awakening if no void occurred. Patients were randomized into three groups and received either 1.66 mcg or 0.83 mcg of NOCTIVA, or a placebo for 12 weeks. The baseline average FUSP for all groups was 2.4 hours. In the NOCTIVA 1.66 mcg group, FUSP increased by 1.8 hours to 4.2 hours, and in the NOCTIVA 0.83 mcg group, FUSP increased by 1.6 hours to 4.0 hours, which was statistically significant compared to placebo. Incidence and severity of adverse events were similar to placebo, and the incidence of hyponatremia, defined as serum sodium less than or equal to125 mmol/L regardless of symptoms or less than130 mmol/L with symptoms, was low for both doses. No patients treated with 0.83 mcg experienced serum sodium less than or equal to125 mmol/L. These results demonstrate that NOCTIVA is an effective therapy with a well-tolerated safety profile in patients with nocturia due to nocturnal polyuria and may provide longer periods of uninterrupted sleep.

AVDL Avadel Pharmaceuticals
$4.37

-0.18 (-3.96%)

08/07/18
JMPS
08/07/18
DOWNGRADE
JMPS
Market Perform
Avadel Pharmaceuticals downgraded to Market Perform from Outperform at JMP Securities
08/07/18
08/07/18
DOWNGRADE
Target $7

Hold
Avadel Pharmaceuticals downgraded to Hold on lower Noctiva sales at SunTrust
As previously reported, SunTrust analyst John Boris downgraded Avadel Pharmaceuticals to Hold from Buy after the company lowered its 2018 revenue guidance for Noctiva. Following the company's Q2 report, Boris cut his Noctiva sales estimate by about 35% and lowered his price target to $7 from $13, citing the lower Noctiva sales view and rising competition for Avadel's Eclat non-strategic assets.
08/07/18
RHCO
08/07/18
DOWNGRADE
RHCO
Hold
Avadel Pharmaceuticals downgraded to Hold from Buy at SunTrust
03/09/18
LTCO
03/09/18
NO CHANGE
Target $24
LTCO
Buy
Avadel Pharmaceuticals price target lowered to $24 from $30 at Ladenburg
Ladenburg Thalmann analyst Matthew Kaplan lowered his price target for Avadel Pharmaceuticals to $24 citing a lack of clarity with respect to the FT 218 new drug application filing. The analyst, however, keeps a Buy rating on the shares following the company's Q4 results.

TODAY'S FREE FLY STORIES

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EEFT

Euronet

$143.81

-2.84 (-1.94%)

21:08
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Earnings
Breaking Earnings news story on Euronet »

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EEFT

Euronet

$143.81

-2.84 (-1.94%)

21:07
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Euronet says revenue growth would have been stronger if not for strong USD »

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EEFT

Euronet

$143.81

-2.84 (-1.94%)

21:06
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Euronet reports Q3 adjusted EBITDA $227.3M vs. $181.4M last year »

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EEFT

Euronet

$143.81

-2.84 (-1.94%)

21:04
10/22/19
10/22
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21:04
Earnings
Euronet reports Q3 adjusted EPS $2.84, consensus $2.80 »

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FFWM

First Foundation

$15.50

0.16 (1.04%)

21:03
10/22/19
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21:03
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21:03
Earnings
First Foundation reports Q3 EPS 39c, consensus 36c »

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KMB

Kimberly-Clark

$129.57

-9.74 (-6.99%)

20:36
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Kimberly-Clark rating change at Deutsche Bank »

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BA

Boeing

$337.45

6.33 (1.91%)

, TMO

Thermo Fisher

$280.89

-2.56 (-0.90%)

20:25
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20:25
Earnings
Notable companies reporting before tomorrow's open »

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BA

Boeing

$337.45

6.33 (1.91%)

TMO

Thermo Fisher

$280.89

-2.56 (-0.90%)

LLY

Eli Lilly

$110.00

2.06 (1.91%)

CAT

Caterpillar

$133.69

1.47 (1.11%)

ANTM

Anthem

$260.28

7.12 (2.81%)

BX

Blackstone

$49.08

-0.025 (-0.05%)

BSX

Boston Scientific

$38.21

-0.45 (-1.16%)

GD

General Dynamics

$179.92

4.49 (2.56%)

NSC

Norfolk Southern

$188.85

2.68 (1.44%)

HLT

Hilton

$90.81

-1.57 (-1.70%)

FCX

Freeport McMoRan

$9.92

0.1 (1.02%)

IVZ

Invesco

$16.03

-0.115 (-0.71%)

OC

Owens Corning

$63.41

-0.055 (-0.09%)

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ACRS

Aclaris Therapeutics

$1.62

0.215 (15.36%)

20:13
10/22/19
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20:13
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20:13
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Aclaris Therapeutics rating change at SVB Leerink »

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AMGN

Amgen

$204.84

1.93 (0.95%)

19:39
10/22/19
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Hot Stocks
Amgen CFO David Meline to retire »

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TRV

Travelers

$130.22

-11.55 (-8.15%)

19:31
10/22/19
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19:31
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Travelers rating change at Deutsche Bank »

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GOOG

Alphabet

$1,242.78

-3.45 (-0.28%)

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Alphabet Class A

$1,241.08

-3.15 (-0.25%)

19:09
10/22/19
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19:09
Periodicals
State AGs plan Google antitrust meeting next month, Reuters says »

U.S. state attorneys…

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Alphabet

$1,242.78

-3.45 (-0.28%)

GOOGL

Alphabet Class A

$1,241.08

-3.15 (-0.25%)

FB

Facebook

$182.27

-7.55 (-3.98%)

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CISN

Cision

$10.08

1.63 (19.29%)

19:03
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Cision rating change at BMO Capital »

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MANH

Manhattan Associates

$74.47

-2.02 (-2.64%)

, TER

Teradyne

$59.24

-0.83 (-1.38%)

18:55
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Hot Stocks
Fly Intel: After Hours Movers »

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MANH

Manhattan Associates

$74.47

-2.02 (-2.64%)

TER

Teradyne

$59.24

-0.83 (-1.38%)

CSL

Carlisle

$144.97

-0.27 (-0.19%)

USNA

Usana

$72.62

2.92 (4.19%)

NAVI

Navient

$12.16

0.19 (1.59%)

DFS

Discover

$81.30

0.85 (1.06%)

HNGR

Hanger

$20.50

0.39 (1.94%)

MRNA

Moderna

$15.90

0.42 (2.71%)

REZI

Resideo

$15.17

0.03 (0.20%)

IRBT

iRobot

$53.88

-1.82 (-3.27%)

TXN

Texas Instruments

$128.61

-2.32 (-1.77%)

INTC

Intel

$52.00

-0.12 (-0.23%)

ADI

Analog Devices

$110.91

-0.18 (-0.16%)

AVGO

Broadcom

$287.54

-2.03 (-0.70%)

NVDA

Nvidia

$195.52

-0.64 (-0.33%)

QCOM

Qualcomm

$78.46

-0.5 (-0.63%)

AMD

AMD

$31.51

-0.54 (-1.68%)

HA

Hawaiian Holdings

$30.14

0.67 (2.27%)

SIX

Six Flags

$51.22

-0.62 (-1.20%)

WHR

Whirlpool

$160.72

0.18 (0.11%)

BYD

Boyd Gaming

$26.17

0.24 (0.93%)

CMG

Chipotle

$831.69

-20.195 (-2.37%)

SNAP

Snap

$14.00

-0.58 (-3.98%)

SKX

Skechers

$38.03

0.55 (1.47%)

SLNO

Soleno Therapeutics

$1.50

0.03 (2.04%)

NOW

ServiceNow

$228.26

-12.315 (-5.12%)

NKE

Nike

$95.61

-0.61 (-0.63%)

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IIPR

Innovative Industrial Properties

$72.50

-1.2 (-1.63%)

18:53
10/22/19
10/22
18:53
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18:53
Hot Stocks
Innovative Industrial Properties investing $46.6M in two IL properties »

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CISN

Cision

$10.08

1.63 (19.29%)

18:51
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18:51
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Cision rating change at BMO Capital »

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LOGI

Logitech

$39.97

-0.75 (-1.84%)

18:42
10/22/19
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18:42
Hot Stocks
Logitech CEO: We had a solid quarter despite macroeconomic noise »

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HAS

Hasbro

$100.00

-20.11 (-16.74%)

18:23
10/22/19
10/22
18:23
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18:23
Hot Stocks
Hasbro CEO: We believe we can grow in Q4 »

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SPY

SPDR S&P 500 ETF Trust

$299.01

-1.04 (-0.35%)

, SPX

S&P 500

$0.00

(0.00%)

18:22
10/22/19
10/22
18:22
10/22/19
18:22
General news
Trump tweets 'good news happening' on Turkey, Syria, Middle East »

President Donald Trump…

SPY

SPDR S&P 500 ETF Trust

$299.01

-1.04 (-0.35%)

SPX

S&P 500

$0.00

(0.00%)

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XOM

Exxon Mobil

$69.11

0.37 (0.54%)

18:20
10/22/19
10/22
18:20
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18:20
Periodicals
NY AG's office says Exxon should pay up to $1.6B in climate trial, NYP says »

Kevin Wallace, a lawyer…

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XOM

Exxon Mobil

$69.11

0.37 (0.54%)

17:58
10/22/19
10/22
17:58
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17:58
Periodicals
Exxon lawyer slams NY climate suit as trial opens, Bloomberg says »

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TER

Teradyne

$59.24

-0.83 (-1.38%)

17:57
10/22/19
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17:57
Hot Stocks
Teradyne jumps 6% after quarterly results, guidance based on 5G demand »

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TER

Teradyne

$59.24

-0.83 (-1.38%)

17:53
10/22/19
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17:53
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17:53
Earnings
Teradyne sees Q4 EPS 73c-84c, consensus 61c »

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LEVI

Levi Strauss

$17.59

0.58 (3.41%)

17:52
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10/22
17:52
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17:52
Hot Stocks
Levi Strauss EVP Love sells 204K shares of common stock »

In a regulatory filing,…

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BK

BNY Mellon

$46.15

0.48 (1.05%)

, WFC

Wells Fargo

$50.63

0.18 (0.36%)

17:51
10/22/19
10/22
17:51
10/22/19
17:51
Periodicals
BNY Mellon vice chairman leaves lender, WSJ says »

Bill Daley, former White…

BK

BNY Mellon

$46.15

0.48 (1.05%)

WFC

Wells Fargo

$50.63

0.18 (0.36%)

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