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DVAX

Dynavax

$10.90

-0.47 (-4.13%)

, MRK

Merck

$72.34

0.12 (0.17%)

12:47
10/21/18
10/21
12:47
10/21/18
12:47

Dynavax's SD-101, Keytruda combo still shows 70% ORR in Advanced Melanoma

Dynavax (DVAX) presented interim data from its ongoing Phase 1b/2 SYNERGY-001 study investigating SD-101, Dynavax's intratumoral TLR9 agonist, in combination with Keytruda, an anti-PD-1 therapy developed by Merck (MRK) in patients with advanced melanoma naive to anti-PD-1/L1 therapy. The company reported results on a total of 87 patients comparing two different doses of SD-101. In the study, 47 patients received less than or equal to 2mg of SD-101 in 1-4 lesions and 40 patients received 8 mg in a single lesion. The primary endpoints of this dose-expansion/dose-finding study are safety and preliminary efficacy. The results showed a 70% overall response rate in advanced melanoma patients naive to anti-PD-1/L1 therapy who received the less than or equal to 2 mg dose of SD-101 and a 48% ORR in the group receiving the 8 mg dose of SD-101. The combination of SD-101 and Keytruda remains well tolerated with adverse events related to SD-101 being transient, mild to moderate flu-like symptoms.

DVAX

Dynavax

$10.90

-0.47 (-4.13%)

MRK

Merck

$72.34

0.12 (0.17%)

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DVAX Dynavax
$10.90

-0.47 (-4.13%)

05/10/18
JPMS
05/10/18
UPGRADE
Target $27
JPMS
Overweight
Dynavax upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Anupam Rama upgraded Dynavax Technologies to Overweight and raised his price target for the shares to $27 from $25 following the company's Q1 results. The analyst believes TLR9 agonist SD-101 is an underappreciated asset.
05/10/18
JPMS
05/10/18
UPGRADE
Target $27
JPMS
Overweight
JPMorgan upgrades Dynavax on 'vastly underappreciated' SD-101
JPMorgan analyst Anupam Rama upgraded Dynavax Technologies to Overweight from Neutral and raised his price target for the shares to $27 from $25. While a Heplisav launch inflection in 2019 is widely expected, the company's SD-101 opportunity is being "vastly underappreciated" at current share levels, Rama tells investors in a research note. SD-101 has shown encouraging early signals of efficacy in both the melanoma and head and neck indications, the analyst contends. Rama points out that a Phase 2 melanoma update is expected next month at ASCO. He likes the stocks' reward/risk profile going into the readout. The analyst sees 30%-60% upside potential versus 0%-10% downside risk on the data.
05/17/18
JPMS
05/17/18
NO CHANGE
JPMS
Overweight
Dynavax should trade to $21-$22 on abstract data, says JPMorgan
JPMorgan analyst Anupam Rama believes shares of Dynavax should trade up 5%-15% to the $21-$22 range on the SD-101 melanoma ASCO abstract. While some on the Street were inappropriately setting the benchmark at 70%-80% overall response, the abstract data "very much put the early efficacy signals" of SD-101 plus pembrolizumab in the ballpark of nivolumab plus ipilimumab from CHECKMATE-067, with a cleaner safety profile, Rama tells investors in a research note. He says the abstract met his "base case / win / upside scenario."
08/07/18
CANT
08/07/18
NO CHANGE
Target $30
CANT
Overweight
Dynavax price target raised to $30 from $27 at Cantor Fitzgerald
Cantor Fitzgerald analyst Elemer Piros raised his price target for Dynavax Technologies to $30 and reiterates an Overweight rating on the shares following the company's Q2 results. The analyst believes there are a "number of opportunities in the near future for Dynavax that could lead to upside for the company," including future Heplisav-B vaccine sales and a Phase 3 trial initiation for SD-101 in advanced melanoma.
MRK Merck
$72.34

0.12 (0.17%)

10/11/18
FBCO
10/11/18
NO CHANGE
Target $81
FBCO
Outperform
Merck price target raised to $81 from $71 at Credit Suisse
Credit Suisse analyst Vamil Divan raised his price target for Merck to $81 from $71, while reiterating an Outperform rating on the shares. While the shares have had a significant move this year, the analyst sees room for additional upside as the company continues to roll out Keytruda, most notably in the 1st line non-small cell lung setting. However, Divan also acknowledges longer-term investors remain concerned about how the company will navigate the Januvia patent expiration in mid-2022.
10/16/18
BTIG
10/16/18
INITIATION
Target $82
BTIG
Buy
Esperion initiated with a Buy at BTIG
BTIG analyst Thomas Shrader initiated Esperion (ESPR) with a Buy rating and a price target of $82, saying that with its development of bempedoic acid, or BA, to reduce cholesterol, the next key question is about the drug's safety. The analyst notes that while the data from Study 1 in May were disappointing, Study 2 readout in the next few weeks should have more answers. Shrader adds that the introduction of "non-stain" into the cholesterol market has already worked for Merck's (MRK) Zetia, and if BA is perceived well on its safety profile, it is "highly supportive" of its investment story.
10/16/18
SBSH
10/16/18
NO CHANGE
Target $79
SBSH
Buy
Merck price target raised to $79 from $70 at Citi
Citi analyst Andrew Baum raised his price target for Merck (MRK) to $79 and reiterates a Buy rating on the shares. Following upward revisions to his Lynparza expectations, the analyst raised his earnings forecasts for Merck by 1%-9% over the 2021 to 2025 timeframe. The analyst anticipates that positive Lynparza first-line ovarian cancer trial will make Lynparza standard of care in wild type first-line ovarian cancer patients and leaving it well positioned to take market share in immuno-oncology based combinations post 2021. Baum also raised his price target for AstraZeneca (AZN), Merck's partner on Lynparza, to GBP 70 from GBP 62. He also has a Buy rating on those shares.
10/16/18
WELS
10/16/18
NO CHANGE
WELS
Drug price in ads not impactful, may cause confusion, says Wells Fargo
Wells Fargo analyst David Maris acknowledges that the U.S. Department of Health and Human Services' proposal to include drug prices in advertisements has a "noble goal" of making drugs more affordable and keeping patients well informed. However, given how different list prices are relative to out of pocket costs, "one must ask if this is increasing transparency or likely going to lead to more confusion," he contends. The analyst also believes that the unintended consequence could be worse care, while noting that the drug price information will likely fall into the category of the side effect information in drug ads currently, tuned out by many and will have no material impact. While he supports the idea of increased transparency, Maris wonders whether the potential benefit is not outweighed by the potential negative for the most vulnerable. Publicly traded companies in the space include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).

TODAY'S FREE FLY STORIES

AAPL

Apple

$193.42

2 (1.04%)

, PCG

PG&E

$24.39

6.62 (37.25%)

19:29
11/18/18
11/18
19:29
11/18/18
19:29
Hot Stocks
Fly Intel: Top five weekend stock stories »

Catch up on the…

AAPL

Apple

$193.42

2 (1.04%)

PCG

PG&E

$24.39

6.62 (37.25%)

CBS

CBS

$57.49

0.23 (0.40%)

VIA

Viacom

$37.05

0.96 (2.66%)

VIAB

Viacom

$33.00

1.13 (3.55%)

AMZN

Amazon.com

$1,593.59

-26.41 (-1.63%)

KSS

Kohl's

$72.48

-0.7 (-0.96%)

TGT

Target

$79.67

-1.09 (-1.35%)

HD

Home Depot

$177.11

-0.25 (-0.14%)

TIF

Tiffany

$106.48

0.52 (0.49%)

BBY

Best Buy

$66.41

-1.34 (-1.98%)

TJX

TJX

$51.47

-0.98 (-1.87%)

JCP

J.C. Penney

$1.29

-0.08 (-5.84%)

LB

L Brands

$35.28

-0.41 (-1.15%)

T

AT&T

$30.30

0.18 (0.60%)

BP

BP

$40.85

-0.3 (-0.73%)

CVX

Chevron

$119.14

2.18 (1.86%)

XOM

Exxon Mobil

$78.99

0.81 (1.04%)

RDS.A

Royal Dutch Shell

$62.02

0.34 (0.55%)

RDS.B

Royal Dutch Shell

$63.97

0.19 (0.30%)

APC

Anadarko

$56.39

0.9 (1.62%)

EOG

EOG Resources

$105.21

3.57 (3.51%)

OXY

Occidental Petroleum

$73.32

0.71 (0.98%)

COG

Cabot Oil & Gas

$25.73

0.09 (0.35%)

EQT

EQT Corporation

$16.62

-0.55 (-3.20%)

HAL

Halliburton

$32.46

0.02 (0.06%)

SLB

Schlumberger

$48.24

0.17 (0.35%)

AMGN

Amgen

$194.23

1.83 (0.95%)

THS

TreeHouse

$51.92

0.72 (1.41%)

03/08/13
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    Mar

ZAYO

Zayo Group

$23.70

1.495 (6.73%)

, BX

Blackstone

$32.48

-0.02 (-0.06%)

18:50
11/18/18
11/18
18:50
11/18/18
18:50
Periodicals
Zayo said to get interest from Blackstone-Stonepeak Group, Bloomberg reports »

Zayo (ZAYO) has attracted…

ZAYO

Zayo Group

$23.70

1.495 (6.73%)

BX

Blackstone

$32.48

-0.02 (-0.06%)

KKR

KKR

$21.83

-0.46 (-2.06%)

03/08/13
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PCG

PG&E

$24.39

6.62 (37.25%)

18:08
11/18/18
11/18
18:08
11/18/18
18:08
Periodicals
PG&E reports another outage on morning when California started, Reuters says »

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KL

Kirkland Lake Gold

$18.97

0.28 (1.50%)

18:04
11/18/18
11/18
18:04
11/18/18
18:04
Hot Stocks
Kirkland Lake Gold appoints David Soares as CFO, Eric Kallio as senior VP »

Kirkland Lake Gold…

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EXPD

Expeditors

$73.67

0.14 (0.19%)

17:19
11/18/18
11/18
17:19
11/18/18
17:19
Conference/Events
Expeditors management to meet with Wolfe Research »

Meeting to be held in…

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  • 19

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CBS

CBS

$57.49

0.23 (0.40%)

, VIAB

Viacom

$33.00

1.13 (3.55%)

16:54
11/18/18
11/18
16:54
11/18/18
16:54
Periodicals
CBS, Viacom merger could be a few months away, NY Post reports »

After CBS (CBS) CEO Les…

CBS

CBS

$57.49

0.23 (0.40%)

VIAB

Viacom

$33.00

1.13 (3.55%)

VIA

Viacom

$37.05

0.96 (2.66%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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AIMT

Aimmune

$29.61

0.05 (0.17%)

16:51
11/18/18
11/18
16:51
11/18/18
16:51
Hot Stocks
PALISADE trial of Aimmune's AR101 published in New England Journal of Medicine »

Aimmune Therapeutics…

03/08/13
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T

AT&T

$30.30

0.18 (0.60%)

, CMCSA

Comcast

$38.60

0.11 (0.29%)

16:31
11/18/18
11/18
16:31
11/18/18
16:31
Hot Stocks
Box Office Battle: 'Fantastic Beasts 2' wins weekend with $62M »

AT&T (T) subsidiary…

T

AT&T

$30.30

0.18 (0.60%)

CMCSA

Comcast

$38.60

0.11 (0.29%)

CMCSK

Comcast

$0.00

(0.00%)

SNE

Sony

$50.80

-0.81 (-1.57%)

FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

FOXA

21st Century Fox

$48.18

-0.11 (-0.23%)

LGF.A

Lionsgate

$20.88

0.365 (1.78%)

DIS

Disney

$116.20

-0.9 (-0.77%)

VIAB

Viacom

$33.00

1.13 (3.55%)

VIA

Viacom

$37.05

0.96 (2.66%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 03

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VLKAY

Volkswagen

$0.00

(0.00%)

, GOOG

Alphabet

$1,062.01

-2.73 (-0.26%)

15:45
11/18/18
11/18
15:45
11/18/18
15:45
Periodicals
Volkswagen CEO says Waymo has 1/2-year head start, Reuters reports »

Volkwagen (VLKAY) is up…

VLKAY

Volkswagen

$0.00

(0.00%)

GOOG

Alphabet

$1,062.01

-2.73 (-0.26%)

GOOGL

Alphabet Class A

$1,069.13

-2.09 (-0.20%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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T

AT&T

$30.30

0.18 (0.60%)

, FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

15:21
11/18/18
11/18
15:21
11/18/18
15:21
Hot Stocks
AT&T, Fox Networks renew multi-year deal across distribution platforms »

AT&T (T) and Fox…

T

AT&T

$30.30

0.18 (0.60%)

FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

FOXA

21st Century Fox

$48.18

-0.11 (-0.23%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 03

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    Dec

AAPL

Apple

$193.42

2 (1.04%)

13:35
11/18/18
11/18
13:35
11/18/18
13:35
Periodicals
Apple CEO views new regulations as 'inevitable,' Axios reports »

Apple CEO Tim Cook says…

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NSRGY

Nestle

$0.00

(0.00%)

, RIO

Rio Tinto

$50.94

0.89 (1.78%)

13:05
11/18/18
11/18
13:05
11/18/18
13:05
Periodicals
Nespresso, Rio Tinto joining forces to make coffee pods greener, Reuters says »

Nespresso, part of food…

NSRGY

Nestle

$0.00

(0.00%)

RIO

Rio Tinto

$50.94

0.89 (1.78%)

03/08/13
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SNOA

Sonoma Pharmaceuticals

$1.11

-0.095 (-7.92%)

12:54
11/18/18
11/18
12:54
11/18/18
12:54
Hot Stocks
Sonoma Pharmaceuticals announces pricing of public offering of units »

Sonoma Pharmaceuticals…

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NVS

Novartis

$87.74

0.52 (0.60%)

, DBVT

DBV Technologies

$16.70

0.31 (1.89%)

04:55
11/18/18
11/18
04:55
11/18/18
04:55
Conference/Events
American College of Allergy, Asthma & Immunology to hold a meeting »

2018 ACAAI Meeting will…

NVS

Novartis

$87.74

0.52 (0.60%)

DBVT

DBV Technologies

$16.70

0.31 (1.89%)

REGN

Regeneron

$345.10

3.56 (1.04%)

SHPG

Shire

$175.59

-3.39 (-1.89%)

TEVA

Teva

$22.25

-0.37 (-1.64%)

SNY

Sanofi

$45.11

0.56 (1.26%)

GSK

GlaxoSmithKline

$40.35

-0.06 (-0.15%)

AZN

AstraZeneca

$40.67

-0.685 (-1.66%)

CHD

Church & Dwight

$65.42

-0.39 (-0.59%)

BSX

Boston Scientific

$37.22

0.75 (2.06%)

03/08/13
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PDVW

pdvWireless

$39.84

0.06 (0.15%)

16:30
11/17/18
11/17
16:30
11/17/18
16:30
Conference/Events
pdvWireless management to meet with Morgan Stanley »

Meeting to be held in…

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03/06/13
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CBS

CBS

$57.49

0.23 (0.40%)

16:28
11/17/18
11/17
16:28
11/17/18
16:28
Conference/Events
CBS management to meet with Morgan Stanley »

Meeting to be held in…

03/08/13
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  • 19

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THS

TreeHouse

$51.92

0.72 (1.41%)

, CAG

Conagra Brands

$33.09

0.66 (2.04%)

12:54
11/17/18
11/17
12:54
11/17/18
12:54
Periodicals
Treehouse Foods stock may have room to gain, Barron's says »

Treehouse Foods (THS)…

THS

TreeHouse

$51.92

0.72 (1.41%)

CAG

Conagra Brands

$33.09

0.66 (2.04%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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AMGN

Amgen

$194.23

1.83 (0.95%)

12:51
11/17/18
11/17
12:51
11/17/18
12:51
Periodicals
Amgen may be 'a remedy' for tougher times, Barron's says »

Amgen may be a stock that…

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    Dec

AAPL

Apple

$193.42

2 (1.04%)

, LITE

Lumentum

$41.50

0.46 (1.12%)

12:47
11/17/18
11/17
12:47
11/17/18
12:47
Periodicals
Apple stock could continue to slide, Barron's says »

Apple's (AAPL) stock…

AAPL

Apple

$193.42

2 (1.04%)

LITE

Lumentum

$41.50

0.46 (1.12%)

QRVO

Qorvo

$66.32

1.18 (1.81%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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APC

Anadarko

$56.39

0.9 (1.62%)

, RDS.B

Royal Dutch Shell

$63.97

0.19 (0.30%)

12:41
11/17/18
11/17
12:41
11/17/18
12:41
Periodicals
Investors may find bargains among oil, natural gas stocks, Barron's says »

Investors have been…

APC

Anadarko

$56.39

0.9 (1.62%)

RDS.B

Royal Dutch Shell

$63.97

0.19 (0.30%)

RDS.A

Royal Dutch Shell

$62.02

0.34 (0.55%)

XOM

Exxon Mobil

$78.99

0.81 (1.04%)

CVX

Chevron

$119.14

2.18 (1.86%)

BP

BP

$40.85

-0.3 (-0.73%)

EOG

EOG Resources

$105.21

3.57 (3.51%)

OXY

Occidental Petroleum

$73.32

0.71 (0.98%)

COG

Cabot Oil & Gas

$25.73

0.09 (0.35%)

EQT

EQT Corporation

$16.62

-0.55 (-3.20%)

HAL

Halliburton

$32.46

0.02 (0.06%)

SLB

Schlumberger

$48.24

0.17 (0.35%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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LB

L Brands

$35.28

-0.41 (-1.15%)

, JCP

J.C. Penney

$1.29

-0.08 (-5.84%)

12:34
11/17/18
11/17
12:34
11/17/18
12:34
Periodicals
Kohl's, Target set to thrive this holiday season, Barron's says »

Store chains have been…

LB

L Brands

$35.28

-0.41 (-1.15%)

JCP

J.C. Penney

$1.29

-0.08 (-5.84%)

TJX

TJX

$51.47

-0.98 (-1.87%)

BBY

Best Buy

$66.41

-1.34 (-1.98%)

TIF

Tiffany

$106.48

0.52 (0.49%)

HD

Home Depot

$177.11

-0.25 (-0.14%)

TGT

Target

$79.67

-1.09 (-1.35%)

KSS

Kohl's

$72.48

-0.7 (-0.96%)

AMZN

Amazon.com

$1,593.59

-26.41 (-1.63%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
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T

AT&T

$30.30

0.18 (0.60%)

, FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

09:18
11/17/18
11/17
09:18
11/17/18
09:18
OnTheFly
Week in review: How Trump's policies moved stocks »

Catch up on the top…

T

AT&T

$30.30

0.18 (0.60%)

FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

FOXA

21st Century Fox

$48.18

-0.11 (-0.23%)

AMZN

Amazon.com

$1,593.59

-26.41 (-1.63%)

CMCSA

Comcast

$38.60

0.11 (0.29%)

CMCSK

Comcast

$0.00

(0.00%)

DDAIF

Daimler AG

$0.00

(0.00%)

FCAU

Fiat Chrysler

$16.46

-0.12 (-0.72%)

F

Ford

$9.05

-0.26 (-2.79%)

GM

General Motors

$35.76

0.21 (0.59%)

HMC

Honda

$28.21

0.01 (0.04%)

NSANY

Nissan

$0.00

(0.00%)

TM

Toyota

$116.87

-0.02 (-0.02%)

VLKAY

Volkswagen

$0.00

(0.00%)

NYT

New York Times

$26.30

-0.2 (-0.75%)

03/08/13
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NVS

Novartis

$87.74

0.52 (0.60%)

, DBVT

DBV Technologies

$16.70

0.31 (1.89%)

04:55
11/17/18
11/17
04:55
11/17/18
04:55
Conference/Events
American College of Allergy, Asthma & Immunology to hold a meeting »

2018 ACAAI Meeting will…

NVS

Novartis

$87.74

0.52 (0.60%)

DBVT

DBV Technologies

$16.70

0.31 (1.89%)

REGN

Regeneron

$345.10

3.56 (1.04%)

SHPG

Shire

$175.59

-3.39 (-1.89%)

TEVA

Teva

$22.25

-0.37 (-1.64%)

SNY

Sanofi

$45.11

0.56 (1.26%)

GSK

GlaxoSmithKline

$40.35

-0.06 (-0.15%)

AZN

AstraZeneca

$40.67

-0.685 (-1.66%)

CHD

Church & Dwight

$65.42

-0.39 (-0.59%)

BSX

Boston Scientific

$37.22

0.75 (2.06%)

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MSI

Motorola Solutions

$129.97

0.72 (0.56%)

18:48
11/16/18
11/16
18:48
11/16/18
18:48
Hot Stocks
Motorola Solutions: ITC confirms Hytera products infringe Motorola patents »

Motorola Solutions…

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PCG

PG&E

$24.39

6.62 (37.25%)

18:23
11/16/18
11/16
18:23
11/16/18
18:23
Periodicals
CPUC isn't ruling out board shuffle, breakup for PG&E, Bloomberg says »

The California Public…

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