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MRK

Merck

$72.34

0.12 (0.17%)

12:52
10/21/18
10/21
12:52
10/21/18
12:52

Merck presents early data for STING agonist in advanced solid tumors/lymphomas

Merck announced the first presentation of preliminary data from a Phase 1 clinical trial evaluating MK-1454, an investigational STING agonist, as monotherapy and in combination with Keytruda, Merck's anti-PD-1 therapy, in patients with advanced solid tumors or lymphomas. MK-1454 is one of more than 20 novel investigational immuno-therapeutic candidates Merck is evaluating as part of its broad oncology pipeline. In this Phase 1, open-label, multi-arm, multicenter, dose-escalation clinical trial, MK-1454 was administered to patients with advanced solid tumors or lymphomas by intratumoral injection every week for nine weeks for three cycles then every three weeks thereafter. Dose escalations for MK-1454 were 10-3,000 microg and 90-2,000 microg using accelerated titration followed by modified toxicity probability interval design. Keytruda was administered as an intravenous injection at a dose of 200 mg every three weeks. Patients receiving MK-1454 as monotherapy who progressed while on therapy were eligible for crossover to the MK-1454-Keytruda combination arm. Study objectives included evaluation of safety, tolerability, pharmacodynamics, pharmacokinetics and tumor responses evaluated using RECIST v1.1 criteria. Interim data presented at ESMO were based on findings from 26 patients enrolled in the MK-1454 monotherapy arm and 25 patients enrolled in the combination arm with Keytruda, plus 9 patients who crossed over from monotherapy to receive the combination regimen. In the monotherapy arm, no complete or partial responses were observed. In the combination arm, partial responses were observed in 24% of patients, with median reductions of 83% in the size of both target-injected and non-injected tumors. At the time of analysis, all of the partial responses were ongoing and had lasted six months or longer. None of the responders had previously received a PD-1/PD-L1 inhibitor therapy. The disease control rates were 20% and 48% for the monotherapy and combination arms, respectively. Treatment-related adverse events occurred in 82.6% and 82.1% of patients in monotherapy and combination arms, respectively. TRAEs resulting in trial discontinuation occurred in 7.1% of patients in the combination arm. No TRAE discontinuations were recorded in patients in the monotherapy arm.

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MRK Merck
$72.34

0.12 (0.17%)

10/16/18
WELS
10/16/18
NO CHANGE
WELS
Drug price in ads not impactful, may cause confusion, says Wells Fargo
Wells Fargo analyst David Maris acknowledges that the U.S. Department of Health and Human Services' proposal to include drug prices in advertisements has a "noble goal" of making drugs more affordable and keeping patients well informed. However, given how different list prices are relative to out of pocket costs, "one must ask if this is increasing transparency or likely going to lead to more confusion," he contends. The analyst also believes that the unintended consequence could be worse care, while noting that the drug price information will likely fall into the category of the side effect information in drug ads currently, tuned out by many and will have no material impact. While he supports the idea of increased transparency, Maris wonders whether the potential benefit is not outweighed by the potential negative for the most vulnerable. Publicly traded companies in the space include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).
10/16/18
SBSH
10/16/18
NO CHANGE
Target $79
SBSH
Buy
Merck price target raised to $79 from $70 at Citi
Citi analyst Andrew Baum raised his price target for Merck (MRK) to $79 and reiterates a Buy rating on the shares. Following upward revisions to his Lynparza expectations, the analyst raised his earnings forecasts for Merck by 1%-9% over the 2021 to 2025 timeframe. The analyst anticipates that positive Lynparza first-line ovarian cancer trial will make Lynparza standard of care in wild type first-line ovarian cancer patients and leaving it well positioned to take market share in immuno-oncology based combinations post 2021. Baum also raised his price target for AstraZeneca (AZN), Merck's partner on Lynparza, to GBP 70 from GBP 62. He also has a Buy rating on those shares.
10/16/18
BTIG
10/16/18
INITIATION
Target $82
BTIG
Buy
Esperion initiated with a Buy at BTIG
BTIG analyst Thomas Shrader initiated Esperion (ESPR) with a Buy rating and a price target of $82, saying that with its development of bempedoic acid, or BA, to reduce cholesterol, the next key question is about the drug's safety. The analyst notes that while the data from Study 1 in May were disappointing, Study 2 readout in the next few weeks should have more answers. Shrader adds that the introduction of "non-stain" into the cholesterol market has already worked for Merck's (MRK) Zetia, and if BA is perceived well on its safety profile, it is "highly supportive" of its investment story.
10/11/18
FBCO
10/11/18
NO CHANGE
Target $81
FBCO
Outperform
Merck price target raised to $81 from $71 at Credit Suisse
Credit Suisse analyst Vamil Divan raised his price target for Merck to $81 from $71, while reiterating an Outperform rating on the shares. While the shares have had a significant move this year, the analyst sees room for additional upside as the company continues to roll out Keytruda, most notably in the 1st line non-small cell lung setting. However, Divan also acknowledges longer-term investors remain concerned about how the company will navigate the Januvia patent expiration in mid-2022.

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BA

Boeing

$344.09

-25.04 (-6.78%)

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Facebook

$185.96

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FB

Facebook

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T

AT&T

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0.64 (1.69%)

CMCSA

Comcast

$45.58

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CMCSK

Comcast

$0.00

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DIS

Disney

$130.91

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NFLX

Netflix

$275.40

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AMZN

Amazon.com

$1,757.77

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COP

ConocoPhillips

$53.99

-0.55 (-1.01%)

GMVHF

GVC Holdings

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CPTA

Capitala Finance

$9.11

0.13 (1.45%)

19:23
10/20/19
10/20
19:23
10/20/19
19:23
Downgrade
Capitala Finance rating change  »

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    Nov

GM

General Motors

$36.19

-0.01 (-0.03%)

, F

Ford

$9.29

0.18 (1.98%)

19:13
10/20/19
10/20
19:13
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19:13
Periodicals
GM contract terms may be hard for rivals, NY Times says »

General Motors (GM) made…

GM

General Motors

$36.19

-0.01 (-0.03%)

F

Ford

$9.29

0.18 (1.98%)

FCAU

Fiat Chrysler

$13.22

0.085 (0.65%)

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TRI

Thomson Reuters

$66.73

-0.08 (-0.12%)

19:09
10/20/19
10/20
19:09
10/20/19
19:09
Hot Stocks
Thomson Reuters issues statement on CEO succession planning »

Thomson Reuters has…

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  • 31

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T

AT&T

$38.46

0.64 (1.69%)

, CMCSA

Comcast

$45.58

-0.36 (-0.78%)

16:45
10/20/19
10/20
16:45
10/20/19
16:45
On The Fly
Box Office Battle: 'Maleficent 2' wins weekend with just $36M »

"Box Office Battle" is…

T

AT&T

$38.46

0.64 (1.69%)

CMCSA

Comcast

$45.58

-0.36 (-0.78%)

CMCSK

Comcast

$0.00

(0.00%)

SNE

Sony

$59.23

-0.83 (-1.38%)

LGF.A

Lionsgate

$8.47

-0.13 (-1.51%)

LGF.B

Lionsgate

$7.96

-0.11 (-1.36%)

DIS

Disney

$130.91

-1.46 (-1.10%)

VIAB

Viacom

$22.05

-0.56 (-2.48%)

VIA

Viacom

$24.80

-0.8 (-3.13%)

03/08/13
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03/06/13
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FB

Facebook

$185.96

-4.435 (-2.33%)

16:16
10/20/19
10/20
16:16
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16:16
Periodicals
Facebook open to currency-pegged stablecoins, Reuters reports »

Facebook, facing growing…

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WYNN

Wynn Resorts

$113.55

-0.49 (-0.43%)

16:12
10/20/19
10/20
16:12
10/20/19
16:12
Periodicals
Ex-Wynn Resorts worker claims company spied on him, WSJ reports »

A former Wynn Resorts…

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SFTBY

SoftBank

$0.00

(0.00%)

, SFTBF

SoftBank

$0.00

(0.00%)

16:01
10/20/19
10/20
16:01
10/20/19
16:01
Periodicals
SoftBank seeking to avoid WeWork's liabilities with new investment, Reuters says »

SoftBank (SFTBY) is…

SFTBY

SoftBank

$0.00

(0.00%)

SFTBF

SoftBank

$0.00

(0.00%)

WE

We Company

$0.00

(0.00%)

JPM

JPMorgan

$120.60

0.21 (0.17%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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GM

General Motors

$36.19

-0.01 (-0.03%)

15:53
10/20/19
10/20
15:53
10/20/19
15:53
Periodicals
GM strike continues, pain felt by Midwest workers deepens, WSJ says »

With the strike at…

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  • 29

    Oct

BA

Boeing

$344.09

-25.04 (-6.78%)

15:43
10/20/19
10/20
15:43
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15:43
Periodicals
Boeing expresses regret over ex-pilot's 737 Max messages, Reuters says »

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  • 23

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ED

Consolidated Edison

$91.54

0.22 (0.24%)

, MA

MasterCard

$270.90

-5.74 (-2.07%)

15:38
10/20/19
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MasterCard expands Bill Pay Exchange partners »

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ED

Consolidated Edison

$91.54

0.22 (0.24%)

MA

MasterCard

$270.90

-5.74 (-2.07%)

03/08/13
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LAZ

Lazard

$37.09

0.06 (0.16%)

15:33
10/20/19
10/20
15:33
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15:33
Hot Stocks
Lazard announces resignation of Deputy CEO of Financial Advisory »

Lazard announced that…

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ALXN

Alexion

$98.41

-1.53 (-1.53%)

15:25
10/20/19
10/20
15:25
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15:25
Hot Stocks
Alexion ULTOMIRIS receives FDA approval for Atypical Hemolytic Uremic Syndrome »

Alexion Pharmaceuticals…

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BRBR

BellRing Brands

$16.65

-0.04 (-0.24%)

, POST

Post Holdings

$100.65

-0.8 (-0.79%)

09:49
10/20/19
10/20
09:49
10/20/19
09:49
On The Fly
Opening Day: BellRing climbs after $480M IPO »

BellRing Brands (BRBR)…

BRBR

BellRing Brands

$16.65

-0.04 (-0.24%)

POST

Post Holdings

$100.65

-0.8 (-0.79%)

IPHA

Innate Pharma

$6.05

0.19 (3.24%)

KRAT

Karat Packaging

$0.00

(0.00%)

ONEW

OneWater Marine

$0.00

(0.00%)

BRP

BRP Group

$0.00

(0.00%)

PGNY

Progyny

$0.00

(0.00%)

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BA

Boeing

$344.09

-25.04 (-6.78%)

08:31
10/19/19
10/19
08:31
10/19/19
08:31
Periodicals
Boeing recovery getting 'a lot more complicated,' Barron's says »

Boeing shares fell on…

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  • 23

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GMVHF

GVC Holdings

$0.00

(0.00%)

08:27
10/19/19
10/19
08:27
10/19/19
08:27
Periodicals
GVC Holdings looking like 'a good bet,' Barron's says »

GVC Holdings' stock…

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EYE

National Vision

$22.98

-0.94 (-3.93%)

08:19
10/19/19
10/19
08:19
10/19/19
08:19
Periodicals
Street sees National Vision as a buy, some shorts disagree, Barron's says »

National Vision has been…

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CI

Cigna

$167.11

2.3 (1.40%)

, HUM

Humana

$289.59

4 (1.40%)

08:13
10/19/19
10/19
08:13
10/19/19
08:13
Periodicals
Healthcare stocks getting 'back on their feet,' Barron's says »

The sector is the second…

CI

Cigna

$167.11

2.3 (1.40%)

HUM

Humana

$289.59

4 (1.40%)

UNH

UnitedHealth

$245.59

1.84 (0.75%)

WCG

WellCare

$274.54

0.09 (0.03%)

HNT

Health Net

$0.00

(0.00%)

MOH

Molina Healthcare

$123.03

1.47 (1.21%)

TEVA

Teva

$7.50

-0.26 (-3.35%)

AZN

AstraZeneca

$43.86

-0.25 (-0.57%)

BMY

Bristol-Myers

$53.02

0.6 (1.14%)

LLY

Eli Lilly

$108.68

0.24 (0.22%)

GSK

GlaxoSmithKline

$42.52

0.04 (0.09%)

JNJ

Johnson & Johnson

$127.73

-8.47 (-6.22%)

MRK

Merck

$84.68

0.88 (1.05%)

NVS

Novartis

$86.86

-0.395 (-0.45%)

PFE

Pfizer

$36.46

(0.00%)

RHHBY

Roche

$0.00

(0.00%)

SNY

Sanofi

$46.13

-0.43 (-0.92%)

ANTM

Anthem

$249.55

0.3 (0.12%)

CVS

CVS Health

$66.17

-0.31 (-0.47%)

CNC

Centene

$46.92

-0.28 (-0.59%)

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COP

ConocoPhillips

$53.99

-0.55 (-1.01%)

08:03
10/19/19
10/19
08:03
10/19/19
08:03
Periodicals
ConocoPhillips stock looking cheap following selloff, Barron's says »

At a time when Wall…

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  • 29

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AMZN

Amazon.com

$1,757.77

-30.07 (-1.68%)

, NFLX

Netflix

$275.40

-17.88 (-6.10%)

08:00
10/19/19
10/19
08:00
10/19/19
08:00
Periodicals
Comcast stacking up better than investors might expect, Barron's says »

If cord-cutting…

AMZN

Amazon.com

$1,757.77

-30.07 (-1.68%)

NFLX

Netflix

$275.40

-17.88 (-6.10%)

CMCSK

Comcast

$0.00

(0.00%)

CMCSA

Comcast

$45.58

-0.36 (-0.78%)

T

AT&T

$38.46

0.64 (1.69%)

DIS

Disney

$130.91

-1.46 (-1.10%)

03/08/13
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AKS

AK Steel

$2.45

0.055 (2.30%)

, MT

ArcelorMittal

$14.58

0.03 (0.21%)

07:41
10/19/19
10/19
07:41
10/19/19
07:41
On The Fly
Week in Review: How Trump's policies moved stocks »

Catch up on the top…

AKS

AK Steel

$2.45

0.055 (2.30%)

MT

ArcelorMittal

$14.58

0.03 (0.21%)

NUE

Nucor

$51.69

-0.11 (-0.21%)

STLD

Steel Dynamics

$28.71

-0.04 (-0.14%)

TMST

TimkenSteel

$5.42

-0.015 (-0.28%)

X

U.S. Steel

$10.72

0.1 (0.94%)

GM

General Motors

$36.19

-0.01 (-0.03%)

03/08/13
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03/06/13
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03/06/13
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AAVMY

ABN Amro

$0.00

(0.00%)

, BBVA

Banco Bilbao

$5.38

0.07 (1.32%)

04:55
10/19/19
10/19
04:55
10/19/19
04:55
Conference/Events
Institute of International Finance to hold annual meeting »

2019 IIF Annual Meeting…

AAVMY

ABN Amro

$0.00

(0.00%)

BBVA

Banco Bilbao

$5.38

0.07 (1.32%)

BCS

Barclays

$8.48

0.11 (1.31%)

BLK

BlackRock

$445.26

-5.56 (-1.23%)

BNPQY

BNP Paribas

$0.00

(0.00%)

C

Citi

$69.76

0.16 (0.23%)

CAIXY

CaixaBank

$0.00

(0.00%)

CIB

Bancolombia

$49.65

0.12 (0.24%)

CS

Credit Suisse

$12.34

0.045 (0.37%)

EV

Eaton Vance

$44.07

-0.49 (-1.10%)

GS

Goldman Sachs

$206.61

0.13 (0.06%)

HSBC

HSBC

$38.72

-0.165 (-0.42%)

JPM

JPMorgan

$120.60

0.21 (0.17%)

MA

MasterCard

$270.90

-5.74 (-2.07%)

MCO

Moody's

$217.41

-1.33 (-0.61%)

MS

Morgan Stanley

$43.70

0.25 (0.58%)

NYT

New York Times

$29.76

0.21 (0.71%)

PYPL

PayPal

$101.25

-2.38 (-2.30%)

RBS

RBS

$6.14

0.205 (3.46%)

RY

Royal Bank of Canada

$81.49

0.38 (0.47%)

SMFG

Sumitomo Mitsui

$6.87

-0.04 (-0.58%)

SPGI

S&P Global

$250.62

-2.15 (-0.85%)

STT

State Street

$63.40

3.69 (6.18%)

UBS

UBS

$11.35

0.09 (0.80%)

V

Visa

$175.83

-2.11 (-1.19%)

ZURVY

Zurich Insurance

$0.00

(0.00%)

03/08/13
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03/08/13
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03/06/13
Citigroup
03/06/13
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STT

State Street

$63.40

3.69 (6.18%)

20:09
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10/18
20:09
10/18/19
20:09
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State Street rating change at Keefe Bruyette »

State Street upgraded to…

03/08/13
Wedge Partners
03/08/13
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  • 18

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SUN

Sunoco

$32.43

0.32 (1.00%)

19:53
10/18/19
10/18
19:53
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19:53
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Sunoco rating change at BMO Capital »

Sunoco upgraded to Market…

03/08/13
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TLF

Tandy Leather

$4.61

(0.00%)

18:24
10/18/19
10/18
18:24
10/18/19
18:24
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Tandy Leather CFO Castillo to step down »

Tandy Leather Factory…

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