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NCNA

NuCana

$18.90

1.9 (11.18%)

14:09
10/21/18
10/21
14:09
10/21/18
14:09

NuCana reports additional data on NUC-1031 in advanced biliary tract cancer

NuCana announced combined results from cohorts one and two of the ABC-08 study at the European Society for Medical Oncology Congress 2018 in Munich, Germany. In this Phase Ib multi-center, open-label study in front-line treatment of patients with advanced biliary tract cancer, Acelarin combined with cisplatin was observed to continue to achieve approximately a doubling of the response rate expected with the standard of care, gemcitabine plus cisplatin. In addition, results showed the combination was well-tolerated and several patients achieved significant reductions in their tumor volume as well as further tumor shrinkage over time. Fourteen patients with advanced/metastatic biliary tract cancer received Acelarin and cisplatin on days one and eight of a three-week cycle. In the intent-to-treat group of patients, a Complete Radiological Response was achieved in one patient and a Partial Response in six patients, resulting in an Objective Response Rate of 50%. In the eleven Efficacy Evaluable patients, an Objective Response Rate of 64% was achieved. Additionally, the combination of Acelarin and cisplatin was well-tolerated over multiple cycles with no unexpected adverse events, no dose-limiting toxicities, no discontinuations due to Acelarin-associated toxicity and no Grade 4 adverse events. Based on these data from the ABC-08 study and discussions with the U.S. Food and Drug Administration, NuCana anticipates initiating a global randomized Phase III clinical study comparing Acelarin and cisplatin with gemcitabine and cisplatin in patients with front-line advanced biliary tract cancer.

  • 21

    Oct

NCNA NuCana
$18.90

1.9 (11.18%)

10/18/18
PIPR
10/18/18
INITIATION
Target $36
PIPR
Overweight
NuCana initiated with an Overweight at Piper Jaffray
Piper Jaffray analyst Joseph Catanzaro started NuCana with an Overweight rating and $36 price target, stating that data for its lead product, Acelarin, have "strongly" pointed towards platform validation. He sees an opportunity for the drug in platinum-resistant ovarian cancer and sees the potential for it to "establish a new frontline standard of care in biliary tract cancer," Catanzaro tells investors.
10/23/17
WBLR
10/23/17
INITIATION
WBLR
Outperform
NuCana initiated with an Outperform at William Blair
William Blair analyst Y. Katherine Xu started NuCana with an Outperform rating saying her probability-adjusted net present value model derives a fair value of $35 per share at the end of 2018 just based on the company's lead two assets. The analyst forecasts global peak sales of Acelarin in the first four indications, platinum-resistant ovarian cancer, platinum-sensitive ovarian cancer, biliary cancer, and pancreatic cancer-at GBP 800M with 40%-60% probabilities of success. She estimates NUC-3373 to generate peak sales of GBP 960M in the first two indications, advanced colorectal and breast cancers, with a 20% probability of success.
10/23/17
SBSH
10/23/17
INITIATION
Target $23
SBSH
Buy
NuCana initiated with a Buy at Citi
Citi analyst Yigal Nochomovitz started NuCana with a Buy rating and $23 price target. The company's technology platform produces "much-improved versions of decades-old chemo drugs, with minimal innovation risk," the analyst contends.
10/23/17
COWN
10/23/17
INITIATION
COWN
Outperform
NuCana initiated with an Outperform at Cowen

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MDT

Medtronic

$92.31

1.91 (2.11%)

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RDY

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SCCO

Southern Copper

$35.63

-1.615 (-4.34%)

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KBH

KB Home

$19.84

0.37 (1.90%)

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CLDR

Cloudera

$10.69

-0.545 (-4.85%)

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AAPL

Apple

$177.10

-8.7 (-4.68%)

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Apple acquires AI software firm Silk Labs, The Information reports »

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  • 04

    Dec

NVT

nVent Electric

$24.18

-0.35 (-1.43%)

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FB

Facebook

$132.47

0.85 (0.65%)

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  • 28

    Nov

CMCSA

Comcast

$36.75

-1.44 (-3.77%)

, CMCSK

Comcast

$0.00

(0.00%)

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CMCSA

Comcast

$36.75

-1.44 (-3.77%)

CMCSK

Comcast

$0.00

(0.00%)

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  • 03

    Dec

FL

Foot Locker

$46.10

-2.69 (-5.51%)

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Autodesk

$122.99

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$122.99

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BJ

BJ's Wholesale

$19.85

-0.22 (-1.10%)

KEYS

Keysight Technologies

$54.35

-1.23 (-2.21%)

CPRT

Copart

$47.30

-1.255 (-2.58%)

VNET

21Vianet

$11.20

-0.1 (-0.88%)

GPS

Gap

$24.65

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BILI

Bilibili

$13.61

0.575 (4.41%)

DXCM

DexCom

$119.89

-1.34 (-1.11%)

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AAPL

Apple

$177.10

-8.7 (-4.68%)

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  • 04

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FB

Facebook

$132.47

0.85 (0.65%)

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  • 28

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EMCI

EMC Insurance

$32.33

1.1 (3.52%)

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EEX

Emerald Expositions Events

$11.09

0.17 (1.56%)

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LIVN

LivaNova

$98.00

-22.28 (-18.52%)

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BKH

Black Hills

$64.40

0.92 (1.45%)

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GOOG

Alphabet

$1,026.00

7 (0.69%)

, GOOGL

Alphabet Class A

$1,031.22

4.99 (0.49%)

18:19
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Google expands Moffett Park presence again, SVBJ says »

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GOOG

Alphabet

$1,026.00

7 (0.69%)

GOOGL

Alphabet Class A

$1,031.22

4.99 (0.49%)

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SE

Sea Limited

$12.18

-0.52 (-4.09%)

18:04
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Earnings
Sea Limited reports Q3 net loss ($237.6M) vs. ($127.1M) last year »

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BILI

Bilibili

$13.61

0.575 (4.41%)

18:03
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Earnings
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  • 20

    Nov

LTM

Latam Airlines

$9.24

-0.4 (-4.15%)

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  • 21

    Nov

CE

Celanese

$100.26

-1.53 (-1.50%)

18:01
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