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NVS

Novartis

$84.25

-3.76 (-4.27%)

08:06
10/25/18
10/25
08:06
10/25/18
08:06

Compact Imaging, Novartis Pharma collaborate to develop home monitor for AMD, DR

Compact Imaging announced the signing of a collaboration agreement with Novartis Pharma AG under which Novartis will fund Compact Imaging's development of a low-cost home-based monitor to detect disease progression in advanced cases of age-related macular degeneration and diabetic retinopathy. Although drug therapeutics can effectively treat active AMD and diabetic macular edema, the therapeutic regimen can be arduous. For example, in addition to receiving periodic intraocular injections, patients must visit their physicians frequently to have disease progression monitored using a large-scale in-clinic OCT instrument. Although patients, their caregivers and physicians expend considerable time and resources for these visits, treatment often is not indicated. Such "no treatment" visits can become overly burdensome for patients, increasing the already high chances that they will drop out of treatment and risk significant loss of visual acuity. Moreover, as the number of patients with these indications has soared due to an aging population and the diabetes epidemic, the existing care model that has been built around frequent clinic visits has created an unsustainable burden across many healthcare systems. Home retinal monitoring based on Compact Imaging's proprietary MRO technology is expected to provide a simple and affordable solution to these problems. The personal devices will enable quick and easy monitoring in patients' homes. The collected OCT information then will be transmitted via cloud to treating physicians. If the data show the possibility of clinically-significant disease progression, the patient will be promptly notified by his or her treating physician to visit the clinic for a complete diagnostic exam and, if indicated, anti-VEGF treatment. Compact Imaging has already demonstrated the technical feasibility of MRO for use in this application, achieving results comparable to clinical OCT in a study measuring retinal thickness in healthy eyes. The Company expects to begin clinical trials of a prototype system with patients having an active AMD or DME diagnosis in the second half of 2019.

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NVS Novartis
$84.25

-3.76 (-4.27%)

10/18/18
WEDB
10/18/18
DOWNGRADE
WEDB
Neutral
Endocyte downgraded to Neutral from Outperform at Wedbush
Wedbush analyst David Nierengarten downgraded Endocyte (ECYT) to Neutral after the company agreed to be acquired by Novartis (NVS) for $24 per share. The analyst does not next another bidder to emerge.
10/19/18
WELS
10/19/18
DOWNGRADE
WELS
Market Perform
Endocyte downgraded to Market Perform from Outperform at Wells Fargo
Wells Fargo analyst Jim Birchenough downgraded Endocyte (ECYT) to Market Perform from Outperform, citing the company's deal to be acquired by Novartis (NVS). He believes that the proposed acquisition price of $24 per share fairly reflects the potential value of the company's lead PSMA-targeted radionuclide therapeutic and sees Novartis as best positioned to realize that value based on its leadership in radionuclide therapeutics. Birchenough sees low odds of a competing offer and low risk of a material event to derail the acquisition, he added.
10/19/18
HCWC
10/19/18
NO CHANGE
Target $36
HCWC
Buy
Xoma 'undeservedly and overly punished' after CRL, says H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis lowered his price target for Xoma (XOMA) to $36 from $49 after the company's partner Novartis (NVS) disclosed the receipt of a Complete Response Letter from the FDA in response to its application for the claim of cardiovascular risk reduction filed for canakinumab. Though canakinumab is one of the lead contributors to Xoma's valuation, the company's shares have been "undeservedly and overly punished," Pantginis tells investors in a research note. He remains focused on Xoma continuing to diversify its risk profile, highlighted by its recent Agenus (AGEN) transaction. He believes the company's numerous "shots on goal" present a "compelling opportunity" at current share levels.
10/23/18
WOLF
10/23/18
INITIATION
WOLF
Outperform
Novartis reinitiated with an Outperform at Wolfe Research
Wolfe Research analyst Time Anderson reinitiated Novartis with an Outperform.

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MRCY

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LB

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SPOT

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IDXX

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CTRP

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CTRP

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CE

Celanese

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XRAY

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SIM

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CPRT

Copart

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NVS

Novartis

$83.94

1.555 (1.89%)

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