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RTRX

Retrophin

$24.65

0.59 (2.45%)

16:07
10/25/18
10/25
16:07
10/25/18
16:07

Retrophin announces publishing of Phase 2 DUET study results

Retrophin announced that the Journal of the American Society of Nephrology, or JASN, has published the positive results from the Phase 2 DUET Study of sparsentan for the treatment of focal segmental glomerulosclerosis, or FSGS, a rare kidney disorder that often leads to end-stage renal disease, or ESRD. As previously reported, these results demonstrated that the sparsentan treatment group experienced a greater than two-fold reduction of proteinuria compared to the irbesartan treatment group after an eight-week, double-blind treatment period. The publication is being highlighted as part of the Best of ASN Journals session at ASN Kidney Week and will also appear in the November print issue of JASN. An analysis of the secondary endpoint of the study showed that during the eight-week, double-blind treatment period, a significantly greater proportion of patients receiving sparsentan achieved the FSGS partial remission of proteinuria endpoint, or FPRE, defined as UP/C: less than or equal to 1.5 g/g and greater than 40% reduction of proteinuria from baseline, compared to irbesartan-treated patients. In addition, data from patients who were followed out to 48 weeks in the open-label sparsentan treatment period of DUET demonstrated a steady rise in the percentage of patients who achieved FPRE, reaching approximately 60% in patients originally randomized to either sparsentan or irbesartan.

  • 01

    Nov

RTRX Retrophin
$24.65

0.59 (2.45%)

08/17/18
ADAM
08/17/18
INITIATION
Target $36
ADAM
Buy
Retrophin initiated with a Buy at Canaccord
Canaccord analyst Michelle Gilson initiated Retrophin with a Buy rating citing what she views as an attractive valuation given the upside potential provided by the clinical stage pipeline. She sees limited downside risk but upside catalysts with POC data for CNSA-001 in early 2019 and Phase 3 FORT data in PKAN in the second half 2019. Gilson has a $36 price target on Retrophin shares.
04/19/18
HCWC
04/19/18
NO CHANGE
Target $182
HCWC
Buy
H.C. Wainwright reiterates Buy on Ligand after Novartis reports Q1
H.C. Wainwright analyst Joseph Pantginis says the Promacta franchise remains strong after Ligand Pharmaceuticals (LGND) partner Novartis (NVS) reported Q1 sales Promacta revenue of $257M. The analyst projects 2018 is the year that Promacta officially reaches blockbuster status, or $1B in sales. Further, he points out that Retrophin (RTRX), another Ligand partner, earlier this month announced that the first patient has been enrolled into the Phase 3 Duplex study using sparsentan to treat patients with focal segmental glomerulosclerosis. Pantginis is encouraged by the start of the Phase 3 saying it has the potential to lock in a fixed 9% royalty to Ligand, if approved. He currently project peak sales of $825M but feels the drug could reach blockbuster status based on its first-to-market status. Pantginis keeps a Buy rating on Ligand Pharmaceuticals with a $182 price target.

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UBER

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APTO

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TRNX

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AAPL

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SPCB

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USEG

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MYOV

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MYOV

Myovant Sciences

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NVS

Novartis

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, QGEN

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AVH

Avianca

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AAPL

Apple

$179.03

-0.64 (-0.36%)

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SHSP

SharpSpring

$16.37

-0.24 (-1.44%)

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  • 13

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CREG

China Recycling Energy

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FENC

Fennec

$3.88

(0.00%)

16:36
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TD

Toronto-Dominion

$56.66

0.65 (1.16%)

16:35
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16:30
05/24/19
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Options
Preliminary option volume of 15.7M today »

Preliminary option volume…

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