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CMRX

Chimerix

$3.52

0.01 (0.28%)

14:06
10/28/18
10/28
14:06
10/28/18
14:06

Chimerix presents preclinical data showing antiviral activity of Brincidofovir

Chimerix announced data from two preclinical studies which assessed the in vivo antiviral activity of brincidofovir against polyomavirus. These studies are part of the company's ongoing effort to develop antivirals in high unmet medical need areas, including hematopoietic cell transplant and solid organ transplant patient populations. These two studies evaluated BCV's effect against MuPyV, a mouse polyomavirus closely related to the human BK virus. In these studies, mice with MuPyV were treated with BCV either 24 hours after being infected or prophylactically for a full week prior to infection. Data from the two studies show that BCV demonstrated significant antiviral activity against MuPyV and showed no safety signals across BCV doses administered. In mice treated after infection with MuPyV, BCV delivered via intraperitoneal injection once daily, twice weekly or once weekly reduced kidney viral loads by 100-fold relative to those that received placebo, while administration prophylactically showed that BCV 20 mg/kg or higher decreased viral load in the kidney by approximately 10-fold.

CMRX Chimerix
$3.52

0.01 (0.28%)

02/14/18
02/14/18
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. PepsiCo (PEP) downgraded to In Line from Outperform at Evercore ISI with analyst Robert Ottenstein saying that while the company's dividend increase is "important and positive," he no longer expects the company to outperform in the beverage sector amid an "array of issues" at North America Beverage segment limiting upside performance. 2. Spark Therapeutics (ONCE) downgraded to Neutral from Overweight at JPMorgan with analyst Cory Kasimov saying he remains optimistic about the long-term outlook for the company, but notes the shares are now within 10% of his price target following the recent rally. 3. Chimerix (CMRX) downgraded to Underweight from Neutral at JPMorgan with analyst Jessica Fye saying with base-case timing for the AdAPT data well over a year away, the shares will underperform over the near term. 4. Avis Budget (CAR) downgraded to Sell from Neutral at Goldman Sachs with analyst David Tamberrino saying he believes transitory benefits from Hurricane recovery demand are waning, and headwinds from reduced residual values, higher interest rates, continued competition, and increased SG&A expenses will pressure Avis' earnings outlook. 5. Lexicon (LXRX) downgraded to Underweight from Neutral at JPMorgan with analyst Jessica Fye saying the Xermelo launch remains slow, and consensus estimates of $55M and $99M for 2018 and 2019 are too high. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
02/14/18
JPMS
02/14/18
DOWNGRADE
JPMS
Underweight
Chimerix downgraded to Underweight from Neutral at JPMorgan
JPMorgan analyst Jessica Fye downgraded Chimerix to Underweight with no price target. With base-case timing for the AdAPT data well over a year away, the shares will underperform over the near term, Fye tells investors in a research note. The analyst sees "limited transformative catalysts" in the near term.
02/02/18
02/02/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. VF Corp. (VFC) initiated with an Overweight at Barclays. 2. JinkoSolar (JKS) initiated with a Sell at Vertical Group. 3. Chimerix (CMRX) initiated with a Buy at H.C. Wainwright. 4. Voyager Therapeutics (VYGR) initiated with an Overweight at Morgan Stanley. 5. Blue Apron (APRN) initiated with a Buy at Gabelli. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
02/02/18
HCWC
02/02/18
INITIATION
Target $10
HCWC
Buy
Chimerix initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Edward White started Chimerix with a Buy rating and $10 price target. Investors are unfairly discounting the opportunity in the company's current pipeline, White tells investors in a research note. The analyst notes the pipeline includes brincidofovir, a clinical-stage nucleotide that has demonstrated antiviral activity across all five families of DNA viruses. He points out the stock is currently trading around cash levels.

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BG

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Bunge

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IPGP

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CNC

Centene

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QURE

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CNCE

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RCKT

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PSTI

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TLRY

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BG

Bunge

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CGEN

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TRV

Travelers

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TRV

Travelers

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CONN

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AMRX

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TRV

Travelers

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Earnings
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