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SNY

Sanofi

$43.10

0.745 (1.76%)

17:18
10/30/18
10/30
17:18
10/30/18
17:18

Sanofi announces FDA priority review granted for dengue vaccine

The FDA has accepted a biologics license application for Sanofi Pasteur's dengue vaccine. The dengue vaccine candidate has been granted priority review by the FDA as it would represent the first and only medical prevention tool against dengue, including severe dengue, which is considered an unmet medical need. The FDA set a Prescription Drug User Fee Act action date of May 1. Dengue is endemic in the U.S. territories of Puerto Rico and the US Virgin Islands. In 2010, Puerto Rico experienced the largest outbreak when more than 12,000 cases were confirmed. Incidence remained high in subsequent years, particularly in 2012 and 2013. Dengue represents a health and economic burden in Puerto Rico with total annual associated costs reaching an estimated $160.2M. The vaccine, known as Dengvaxia in countries where it is approved, remains the only vaccine available for the prevention of dengue. The European Commission is expected to grant marketing authorization for Dengvaxia in December.

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    Apr

SNY Sanofi
$43.10

0.745 (1.76%)

10/16/18
WELS
10/16/18
NO CHANGE
WELS
Drug price in ads not impactful, may cause confusion, says Wells Fargo
Wells Fargo analyst David Maris acknowledges that the U.S. Department of Health and Human Services' proposal to include drug prices in advertisements has a "noble goal" of making drugs more affordable and keeping patients well informed. However, given how different list prices are relative to out of pocket costs, "one must ask if this is increasing transparency or likely going to lead to more confusion," he contends. The analyst also believes that the unintended consequence could be worse care, while noting that the drug price information will likely fall into the category of the side effect information in drug ads currently, tuned out by many and will have no material impact. While he supports the idea of increased transparency, Maris wonders whether the potential benefit is not outweighed by the potential negative for the most vulnerable. Publicly traded companies in the space include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).
10/17/18
JEFF
10/17/18
NO CHANGE
Target $31
JEFF
Buy
Jefferies still sees 'major' opportunity for Optinose after Dupixent data
Optinose (OPTN) shares underperformed yesterday following the positive Phase 3 results for Sanofi (SNY) and Regeneron's (REGN) Dupixent in treating patients with chronic rhinosinusitis with nasal polyps, Jefferies analyst David Steinberg tells investors in a research note titled "Biologics Competitor as Expected; Real World Pricing Issues Likely to Limit Us." The analyst says that while Dupixent demonstrated strong efficacy, clinicians he's spoken with believe that the "massive" pricing disparity versus nasal steroids will likely result in payer "step edits" that could limit widespread adoption of the "expensive" biologics currently under development. Further, Dupixent's head-to-head comparison with Optinose's Xhance's "strong" efficacy profile is difficult, the analyst adds. Steinberg still sees a "major" long-term opportunity for Xhance and keeps a Buy rating on Optinose with a $31 price target.
10/23/18
WOLF
10/23/18
INITIATION
WOLF
Peer Perform
Sanofi reinitiated with a Peer Perform at Wolfe Research
10/25/18
WELS
10/25/18
NO CHANGE
WELS
Wells Fargo says Trump speech today won't be end of drug pricing proposals
Wells Fargo analyst David Maris notes that Politico and other media outlets are reporting that President Donald Trump will propose several new initiatives to address high drug prices when he speaks later today at the U.S. Department of Health and Human Services. Maris thinks Trump's focus will be on how other countries are "freeloading" on U.S. innovation with lower negotiated pricing, stating that news reports make it appear that the administration is targeting the industry for action, rather than other countries to raise their spending. While Maris acknowledges the timing of the speech being near the mid-term elections, he believes these proposals are simply the follow-though of earlier promises. He also expects this is not the end of proposals to address the issue of U.S. drug pricing. Publicly traded large-cap drugmakers include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).

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BRK.A

Berkshire Hathaway

$302,770.46

-5154.54 (-1.67%)

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Berkshire Hathaway

$201.90

-3.41 (-1.66%)

15:39
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Berkshire Hathaway in advanced talks to sell Applied Underwriters, Reuters says »

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BRK.A

Berkshire Hathaway

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BRK.B

Berkshire Hathaway

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WTW

WW

$29.34

0.27 (0.93%)

15:35
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15:35
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Weight Watchers put volume heavy and directionally bearish »

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15:35
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U.S. Treasury Market Summary »

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15:28
02/22/19
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15:28
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15:28
Conference/Events
House Financial Services Committee to hold a hearing »

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IWM

iShares Trust Russell 2000 Index Fund

$157.79

1 (0.64%)

, RUT

Russell 2000 Index

$0.00

(0.00%)

15:22
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15:22
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On The Fly: Weekly technical notes for Russell 2000 »

For the holiday-shortened…

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iShares Trust Russell 2000 Index Fund

$157.79

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Russell 2000 Index

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XLB

S&P Select Materials SPDR

$55.68

0.14 (0.25%)

, XLE

Energy Select Sector SPDR

$65.66

0.1 (0.15%)

15:22
02/22/19
02/22
15:22
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15:22
Technical Analysis
On The Fly: Weekly technical notes for S&P 500 »

At time of writing the…

XLB

S&P Select Materials SPDR

$55.68

0.14 (0.25%)

XLE

Energy Select Sector SPDR

$65.66

0.1 (0.15%)

XLF

Financial Select Sector

$26.43

-0.085 (-0.32%)

XLI

Industrial Select Sector SPDR

$75.89

0.19 (0.25%)

XLY

Consumer Discretionary Sector SPDR

$110.81

0.31 (0.28%)

XLV

Health Care Select Sector SPDR

$92.29

0.59 (0.64%)

XLK

Technology Select Sector SPDR

$70.39

0.64 (0.92%)

SPY

SPDR S&P 500 ETF Trust

$278.35

0.92 (0.33%)

SPX

S&P 500

$0.00

(0.00%)

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15:21
02/22/19
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Conference/Events
House Appropriations Committee to hold a hearing »

The Subcommittee on…

RF

Regions Financial

$16.16

-0.085 (-0.52%)

15:20
02/22/19
02/22
15:20
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15:20
Options
Call spreads in Regions Financial as bullish positions are adjusted »

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

15:17
02/22/19
02/22
15:17
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15:17
Technical Analysis
NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

15:16
02/22/19
02/22
15:16
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15:16
Technical Analysis
NYSE market internals summary »

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UA

Under Armour

$19.57

0.16 (0.82%)

15:15
02/22/19
02/22
15:15
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15:15
Options
Under Armour put volume heavy and directionally bearish »

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15:15
02/22/19
02/22
15:15
02/22/19
15:15
General news
Treasury Action: Treasuries have been underpinned all day »

Treasury Action:…

ABBV

AbbVie

$79.47

0.71 (0.90%)

, AZN

AstraZeneca

$40.78

0.345 (0.85%)

15:14
02/22/19
02/22
15:14
02/22/19
15:14
Conference/Events
Senate Finance Committee to hold a hearing »

The Committee holds a…

ABBV

AbbVie

$79.47

0.71 (0.90%)

AZN

AstraZeneca

$40.78

0.345 (0.85%)

BMY

Bristol-Myers

$50.75

0.6 (1.20%)

JNJ

Johnson & Johnson

$136.22

0.82 (0.61%)

MRK

Merck

$80.39

0.57 (0.71%)

PFE

Pfizer

$42.91

0.77 (1.83%)

SNY

Sanofi

$41.10

-0.23 (-0.56%)

03/08/13
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MGA

Magna

$54.61

2.015 (3.83%)

15:04
02/22/19
02/22
15:04
02/22/19
15:04
Downgrade
Magna rating change  »

Magna downgraded to Hold…

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LTRPA

Liberty TripAdvisor

$16.20

0.31 (1.95%)

15:04
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02/22
15:04
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15:04
Options
Liberty TripAdvisor options imply 4.8% move in share price post-earnings, above median historical move »

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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$278.32

0.89 (0.32%)

14:59
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14:59
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14:59
Periodicals
U.S. Treasury Secretary says U.S, China reach pact on currency issues, CNBC says »

Steven Mnuchin, U.S.…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$278.32

0.89 (0.32%)

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14:55
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14:55
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14:55
General news
Fed's Bullard doesn't want to be shrinking the balance sheet and cutting rates »

Fed's Bullard…

ALXN

Alexion

$128.46

0.9 (0.71%)

14:52
02/22/19
02/22
14:52
02/22/19
14:52
Hot Stocks
Alexion says FDA grants priority review and accepts sBLA of Soliris »

Alexion Pharmaceuticals…

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  • 20

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14:50
02/22/19
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14:50
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14:50
Conference/Events
Senate Energy & Natural Resources Committee to hold a hearing »

The Committee holds a…

JMEI

Jumei

$2.68

0.19 (7.63%)

14:49
02/22/19
02/22
14:49
02/22/19
14:49
Options
Jumei options imply 7.1% move in share price post-earnings, above median historical move »

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AGR

Avangrid

$48.84

-0.06 (-0.12%)

14:42
02/22/19
02/22
14:42
02/22/19
14:42
Conference/Events
Avangrid to host investor meeting »

Investor meeting to be…

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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$278.77

1.34 (0.48%)

14:42
02/22/19
02/22
14:42
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14:42
Periodicals
Xi tells Trump both sides will redouble efforts to come to trade pact, CNBC says »

In a letter to U.S.…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$278.77

1.34 (0.48%)

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14:40
02/22/19
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14:40
General news
Fed's Quarles confirmed the FOMC's decision to maintain an "ample" reserve balance »

Fed's Quarles…

PDVW

pdvWireless

$46.00

5.105 (12.48%)

14:30
02/22/19
02/22
14:30
02/22/19
14:30
Hot Stocks
pdvWireless move higher attributed to FCC proposed rulemaking notice »

Shares of pdvWireless are…

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14:25
02/22/19
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General news
Action Economics Survey results: »

Action Economics Survey…

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