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OTIC

Otonomy

$2.52

0.03 (1.20%)

07:46
11/06/18
11/06
07:46
11/06/18
07:46

Otonomy to present OTO-413 data at SfN

Otonomy is presenting data on the therapeutic potential of OTO-413, an otic sustained-exposure formulation of brain-derived neurotrophic factor, or BDNF. These promising preclinical data, demonstrating the potential of intratympanic BDNF to repair cochlear synaptopathy, an underlying cause of hearing loss including speech-in-noise hearing difficulty, are being presented as part of the Society for Neuroscience, or SfN. Recent scientific advances have shown that the loss of synaptic connections between inner ear hair cells and spiral ganglion neurons contributes to hearing impairment. This cochlear synaptopathy is proposed as an underlying pathology in age-related and noise-induced hearing loss and is also believed to contribute to the common difficulty of hearing speech in the presence of background noise. Overall, there are more than 50 million people in the U.S. with acquired hearing loss including a significant proportion experiencing speech-in-noise hearing difficulty. Results from these studies demonstrated that a single intratympanic administration of OTO-413 provided sustained-exposure of BDNF to the inner ear and that OTO-413 improved both the structural and functional deficits of cochlear synaptopathy in an animal model.

  • 27

    Nov

OTIC Otonomy
$2.52

0.03 (1.20%)

03/12/18
PIPR
03/12/18
UPGRADE
Target $11
PIPR
Overweight
Otonomy upgraded to Overweight from Neutral at Piper Jaffray
Piper Jaffray analyst Charles Duncan upgraded Otonomy to Overweight and raised his price target for the shares to $11 from $8. The analyst believes the company has sufficient cash and a "clearly articulated" Phase 3 plan. He also believes little value is being accorded to Otividex's potential.
03/19/18
JPMS
03/19/18
DOWNGRADE
JPMS
Underweight
Otonomy downgraded to Underweight from Neutral at JPMorgan
JPMorgan analyst Anupam Rama downgraded Otonomy to Underweight without a price target. The analyst sees "no true value drivers in 2018" with an additional third Phase 3 trial for Otividex in Meniere's disease needed for approval.
08/14/18
RHCO
08/14/18
NO CHANGE
Target $10
RHCO
Buy
Otonomy price target lowered to $10 from $15 at SunTrust
SunTrust analyst Edward Nash lowered his price on Otonomy to $10 and kept his Buy rating, saying that while he remains bullish on the company's position in the "under-addressed neuro-otology space" after its initiated Phase 3 trial for Otividex, he also sees a "lack of near term catalysts". The analyst adds that the next "significant" even will come from the Otividex results in the first half of 2020, but notes that the stock is currently trading "near cash".

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