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SRNE

Sorrento Therapeutics

$3.39

-0.28 (-7.63%)

08:07
11/06/18
11/06
08:07
11/06/18
08:07

Sorrento Therapeutics says anti-CEA CAR-T shows increased OS in trial

Sorrento Therapeutics announced the release of data from a phase 1b clinical trial administering anti-CEA CAR-T by utilizing a unique Pressure-Enabled Drug Delivery manufactured by TriSalus Life Sciences. The preliminary data for the Hepatic Immunotherapy for Metastases clinical trial results will be presented in a poster at the Society for Immunotherapy of Cancer Annual Meeting, being held November 7-11 in Washington, DC. Five patients, four pancreatic and one colorectal, with carcinoembryonic antigen-positive, unresectable stage IV adenocarcinoma with liver metastases, who had failed one or more lines of systemic chemotherapy, each received three hepatic artery infusions of Sorrento autologous anti-CEA CAR-T cells using the Hepatic Immunotherapy for Metastases method. The immunotherapy was delivered by means of PEDD technology, which overpowers the high pressure within solid tumors that limits the reach and efficacy of therapeutic agents. Two out of the four pancreatic cancer patients had no viable liver metastases by PET scan after treatment. After 12 months, one patient with stage IV pancreatic carcinoma still showed no evidence of liver metastases on PET imaging, and his primary pancreatic tumor was well-controlled. A second patient with stage IV pancreatic cancer also had no evidence of liver metastases six weeks after CAR-T/PEDD infusions. Median overall survival post-treatment is 8.3 months and the mean OS is 9.8 months to date. No patient suffered any severe adverse event related to the CAR-T infusions.

SRNE Sorrento Therapeutics
$3.39

-0.28 (-7.63%)

02/20/18
HCWC
02/20/18
NO CHANGE
Target $35
HCWC
Buy
Sorrento Therapeutics price target raised to $35 from $30 at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju raised his price target for Sorrento Therapeutics to $35 following the completion of the Celularity financing. The analyst notes the FDA action date for ZTlido is up next. He reiterates a Buy rating on the shares.
02/28/18
HCWC
02/28/18
NO CHANGE
Target $38
HCWC
Buy
Sorrento price target raised to $38 after ZTlido approval at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju noted that Sorrento Therapeutics' receipt of FDA approval of ZTlido, the company's next-generation topical lidocaine product, came on schedule on the previously-announced PDUFA date of February 28. The analyst, who notes the product is entering the pain management market at a time when promotion of other topical lidocaine products "has virtually disappeared," believes ZTlido could prove to be popular and have a relatively swift commercial ramp. He raised his price target on Sorrento shares to $38 from $35 following the approval and keeps a Buy rating on the stock.
04/03/18
HCWC
04/03/18
NO CHANGE
Target $40
HCWC
Buy
Sorrento target raised to $40 after completed financing at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju raised his price target for Sorrento Therapeutics to $40 from $38 saying the recently completed convertible note financing "provides ample runway." The company now has a sufficient cash runway to fund operations for at least the next 24 months, which removes a near-term overhang, Selvaraju tells investors in a research note. He reiterates a Buy rating on Sorrento.
06/28/18
RILY
06/28/18
INITIATION
Target $14.25
RILY
Buy
Sorrento Therapeutics initiated with a Buy at B. Riley FBR
B. Riley FBR analyst Andrew D'Silva started Sorrento Therapeutics with a Buy rating and $14.25 price target.

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