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SAGE

Sage Therapeutics

$126.24

-0.38 (-0.30%)

14:18
11/06/18
11/06
14:18
11/06/18
14:18

Sage Therapeutics pricing for Zulresso at a premium to Piper Jaffray estimate

Piper Jaffray analyst Danielle Brill, who maintained an Overweight rating and $206 price target on Sage Therapeutics shares, noted that the announced plans to price Zulresso at $25,000-$35,000 per course -- should it be approved on its December 19 PDUFA date -- which is at a premium to Piper's estimated net pricing of $15,000. Brill also noted that the drug's sales force has been hired, which includes ~130 reps, and ~50 patient support/access personnel, and she is awaiting final commercial details following PDUFA announcement.

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SAGE Sage Therapeutics
$126.24

-0.38 (-0.30%)

10/31/18
BMOC
10/31/18
NO CHANGE
Target $203
BMOC
Outperform
BMO sees approval for Sage after Zulresso briefing docs
The FDA this morning released briefing documents for Friday's panel meeting to discuss Sage Therapeutics' Zulresso to treat postpartum depression. It appears the FDA is satisfied with the drug's efficacy and overall tolerability and recognizes a significant unmet need for postpartum depression, BMO Capital analyst Gary Nachman tells investors in a research note. He believes Zulresso will likely be approved on the December 19 FDA action date. Nachman adds, however, that there are some questions on the recommended dosing, since initially the lower dose appears more effective but the doses start to separate during titration when going out beyond 24 hours. He has an Outperform rating on Sage Therapeutics with a $203 price target. The stock in early trading is up 1% to $122.47.
10/31/18
10/31/18
NO CHANGE
Target $206

Overweight
Sage briefing docs 'clearly supportive of approval,' says Piper Jaffray
In a midday research note partially titled "Nothing Too Spooky in Brex Briefing Docs," Piper Jaffray analyst Danielle Brill says this morning's FDA's briefing documents for Sage Therapeutics' brexanolone were overall supportive of approval for postpartum depression. The agency appears comfortable with brexanolone's efficacy, and focused on recommended dosing as a key topic of discussion, Brill writes in a note to investors. The major safety concern, loss of consciousness during infusion which occurred in 4% of women treated, does not appear to be barring of approval, says the analyst. However, Brill adds that while she views the tone of the docs as "clearly supportive of approval," prohibiting administration "at-home" has "obvious negative implications for commercial potential." She has an Overweight rating on Sage Therapeutics with a $206 price target. The stock in midday trading is up 6%, or $7.77, to $129.00.
11/01/18
ADAM
11/01/18
NO CHANGE
Target $220
ADAM
Buy
Sage Therapeutics FDA briefing documents read 'ok,' says Canaccord
Canaccord analyst Sumant Kulkarni noted the FDA posted its briefing documents related to Sage Therapeutics' brexanolone ahead of the advisory committee meeting on the product scheduled for November 2. The analyst said they appear "ok" and said the drug could be the first approved for the treatment of post-partum depression. The analyst said with the stock down roughly 10% since the FDA confirmed the date of the AdCom meeting, he is telling investors to buy the shares. Kulkarni reiterated his Buy rating and $220 price target on Sage Therapeutics shares.

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TI

Telecom Italia

$5.92

-0.12 (-1.99%)

15:33
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CLX

Clorox

$158.67

3.36 (2.16%)

15:27
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AAOI

Applied Optoelectronics

$14.45

-0.17 (-1.16%)

15:19
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Options
Applied Optoelectronics options imply 25.6% move in share price post-earnings, above median historical move »

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

15:17
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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

15:16
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NYSE market internals summary »

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IART

Integra LifeSciences

$55.50

3.58 (6.90%)

15:10
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Recommendations
Integra LifeSciences analyst commentary  »

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HYG

iShares iBoxx $ High Yield Corporate Bond

$85.43

-0.07 (-0.08%)

15:10
02/21/19
02/21
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15:10
Options
Far downside ratio spread opened in High Yield Bond Fund »

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DWDP

DowDuPont

$55.19

-1.06 (-1.88%)

15:06
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Corteva Agriscience announces U.S. launch of Enlist E3 soybeans »

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EXAS

Exact Sciences

$82.81

-0.79 (-0.94%)

15:04
02/21/19
02/21
15:04
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15:04
Options
EXACT Sciences options imply 15.0% move in share price post-earnings, above median historical move »

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GE

General Electric

$10.05

-0.055 (-0.54%)

15:00
02/21/19
02/21
15:00
02/21/19
15:00
Options
100K GE Mar 8th 9 puts bought for 5c with shares flat at $10.10 »

100K GE Mar 8th 9 puts…

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APC

Anadarko

$43.81

-1.35 (-2.99%)

14:59
02/21/19
02/21
14:59
02/21/19
14:59
Periodicals
Anadarko says 4 injured in attack at Mozambique LNG project, Bloomberg reports »

Anadarko Petroleum said…

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ALB

Albemarle

$88.17

5.35 (6.46%)

14:54
02/21/19
02/21
14:54
02/21/19
14:54
Recommendations
Albemarle analyst commentary  »

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PBR

Petrobras

$16.70

-0.01 (-0.06%)

14:53
02/21/19
02/21
14:53
02/21/19
14:53
Periodicals
Brazil minister says Petrobras TOR auction may occur in late 2019, Reuters says »

Brazil's Energy and…

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TI

Telecom Italia

$5.92

-0.12 (-1.99%)

14:51
02/21/19
02/21
14:51
02/21/19
14:51
Hot Stocks
Telecom Italia sees organic group EBITDA to decrease low single digit in 2019 »

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  • 22

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TSU

Tim Participacoes

$16.30

0.03 (0.18%)

14:50
02/21/19
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14:50
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Breaking Hot Stocks news story on Tim Participacoes »

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ROKU

Roku

$51.60

-2.03 (-3.79%)

14:49
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02/21
14:49
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14:49
Options
Roku options imply 18.8% move in share price post-earnings, below median historical move »

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  • 21

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LKSD

LSC Communications

$9.23

-0.17 (-1.81%)

, QUAD

Quad/Graphics

$15.85

-0.42 (-2.58%)

14:47
02/21/19
02/21
14:47
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14:47
Conference/Events
Quad/Graphics to host special shareholder meeting »

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LKSD

LSC Communications

$9.23

-0.17 (-1.81%)

QUAD

Quad/Graphics

$15.85

-0.42 (-2.58%)

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FB

Facebook

$160.21

-2.4 (-1.48%)

14:46
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Periodicals
Kids advocacy groups urge FTC to probe Facebook over game purchases, Adweek says »

Childrens' advocacy…

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QUAD

Quad/Graphics

$15.80

-0.47 (-2.89%)

, LKSD

LSC Communications

$9.23

-0.17 (-1.81%)

14:41
02/21/19
02/21
14:41
02/21/19
14:41
Conference/Events
LSC Communications to host special shareholder meeting »

Special Shareholder…

QUAD

Quad/Graphics

$15.80

-0.47 (-2.89%)

LKSD

LSC Communications

$9.23

-0.17 (-1.81%)

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  • 22

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GIL

Gildan Activewear

$34.04

-0.13 (-0.38%)

14:37
02/21/19
02/21
14:37
02/21/19
14:37
Downgrade
Gildan Activewear rating change  »

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  • 21

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TSU

Tim Participacoes

$16.30

0.03 (0.18%)

14:37
02/21/19
02/21
14:37
02/21/19
14:37
Earnings
Tim Participacoes releases guidance for 2019-2021 »

In a regulatory filing,…

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CTRP

Ctrip

$32.55

-1.24 (-3.67%)

14:35
02/21/19
02/21
14:35
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14:35
Options
Ctrip.com put volume heavy and directionally bearish »

Bearish flow noted in…

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NAII

Natural Alternatives International

$11.15

(0.00%)

14:34
02/21/19
02/21
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14:34
Hot Stocks
Natural Alternatives International hires David Brook for sports nutrition unit »

Natural Alternatives…

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NTDOY

Nintendo

$0.00

(0.00%)

14:24
02/21/19
02/21
14:24
02/21/19
14:24
Hot Stocks
Nintendo of America president, COO Reggie Fils-Aime to retire »

Nintendo announced that,…

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