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INFI

Infinity Pharmaceuticals

$2.39

-0.03 (-1.24%)

13:01
11/11/18
11/11
13:01
11/11/18
13:01

Infinity Pharmaceuticals reports data from MARIO-1 Phase 1b study

Infinity Pharmaceuticals announced that data to be presented at the 33rd Annual Meeting of the Society for Immunotherapy of Cancer demonstrated preliminary evidence that IPI-549 in combination with Opdivo is clinically active in indications not expected to respond to Opdivo alone. In particular, evidence of reversal of resistance to Opdivo included a partial response in a patient with metastatic melanoma who progressed on immediate prior Opdivo therapy. IPI-549 plus Opdivo also resulted in a 26% reduction of tumor target lesions in a patient with chemotherapy-resistant triple negative breast cancer, a tumor type intrinsically resistant to checkpoint inhibition. The data also included long-term follow up on sustained partial responses in two patients from combination dose escalation: one with microsatellite stable gallbladder cancer and one with adrenocortical carcinoma. The observed early clinical activity from the combination expansion, in addition to findings from the monotherapy cohorts, including associated translational data, support on-mechanism proof of concept for IPI-549. Infinity is evaluating IPI-549 in MARIO-1, a Phase 1b study in approximately 200 patients with advanced solid tumors. Additionally, Infinity is planning to initiate MARIO-275, a global, randomized Phase 2 study to evaluate the effect of adding IPI-549 to Opdivo in approximately 150 checkpoint-inhibitor naive advanced urothelial cancer patients who have progressed or recurred following treatment with platinum-based chemotherapy.

  • 15

    Nov

INFI Infinity Pharmaceuticals
$2.39

-0.03 (-1.24%)

05/31/18
GHSC
05/31/18
INITIATION
Target $4
GHSC
Buy
Infinity Pharmaceuticals initiated with a Buy at Seaport Global
Seaport Global analyst Corey Davis initiated Infinity Pharmaceuticals with a Buy and $4 price target. The analyst believes 2018 could be a "break-out" year with new data on its lead compound IPI-549 in combination with Opdivo for various tumor types with June 4 at ASXO form its "dose escalation" cohort, Q2 initial data from the "dose expansion" cohort, and more mature data from the "dose expansion" later in the year.
05/31/18
05/31/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Wyndham Hotels & Resorts (WH) initiated with a Buy at Jefferies and an Overweight at JPMorgan. 2. Nxt-ID (NXTD) initiated with a Buy at Euro Pacific. 3. Infinity Pharmaceuticals (INFI) initiated with a Buy at Seaport Global. 4. Edwards Lifesciences (EW) and Medtronic (MDT) were initiated with an Outperform at Raymond James. 5. Rollins (ROL) initiated with a Hold at Stifel. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

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SPX

S&P 500

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C

Citi

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LION

Fidelity Southern

$28.41

-0.16 (-0.56%)

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BMY

Bristol-Myers

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Raytheon

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JPM

JPMorgan

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  • 26

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PHG

Philips

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LMFA

LM Funding

$2.19

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NWSA

News Corp.

$12.42

0.03 (0.24%)

12:25
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FDC

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$22.17

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  • 03

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BLK

BlackRock

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MS

Morgan Stanley

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MS

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JNJ

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SHLD

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MTB

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LPCN

Lipocine

$2.24

0.65 (40.88%)

12:17
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Lipocine analyst commentary  »

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