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EIDX

Eidos Therapeutics

$12.71

0.34 (2.75%)

13:11
11/11/18
11/11
13:11
11/11/18
13:11

Eidos Therapeutics announces positive Phase 2 data for AG10

Eidos Therapeutics announced positive results of its Phase 2 clinical trial studying AG10 in subjects with symptomatic transthyretin amyloidosis cardiomyopathy. The data were presented in a late-breaking Featured Science oral presentation at the American Heart Association Scientific Sessions. AG10 was well tolerated, demonstrated greater than 90% TTR average stabilization at day 28, and increased serum TTR concentrations, a prognostic indicator of survival in ATTR-CM, in a dose-dependent manner. Subject to discussions with regulatory agencies, these data support the advancement of AG10 into Phase 3 pivotal trials planned to be initiated in the first half of 2019. The study met its primary objective of establishing that AG10 was well tolerated with no safety signals of potential clinical concern related to the administration of AG10 in symptomatic ATTR-CM patients. One serious adverse event of dyspnea deemed unrelated to study drug was observed in one actively-treated subject and SAEs of atrial fibrillation, congestive heart failure, and cellulitis were observed in two placebo-treated subjects. The overall rate of adverse events was 69% in subjects administered 800 mg bid AG10, 63% in subjects administered 400 mg bid AG10, and 88% in subjects administered placebo. As compared to placebo, subjects treated with AG10 demonstrated a statistically significant increase in serum TTR concentrations, a prognostic indicator of survival in ATTR-CM patients, in a dose-dependent manner. Subjects administered 800 mg AG10 twice daily, 400 mg AG10 twice daily, and placebo exhibited mean changes in TTR concentration from baseline of +50%, +36% and -7%, respectively, at day 28. All subjects administered AG10 had serum TTR concentrations within the normal range at day 28, whereas 31% of subjects administered placebo had serum TTR concentrations below the normal range on day 28. AG10 administration resulted in near-complete stabilization of TTR at day 28, across the dosing interval in all actively treated subjects as measured by established ex vivo assays.

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EIDX Eidos Therapeutics
$12.71

0.34 (2.75%)

08/27/18
JPMS
08/27/18
NO CHANGE
JPMS
Eidos Therapeutics selloff today overdone, says JPMorgan
JPMorgan analyst Anupam Rama views this morning's selloff in shares of Eidos Therapeutics (EIDX) following the data from Pfizer (PFE) as overdone. The stock in early trading is down 33%, or $6.65, to $13.58.
08/27/18
JPMS
08/27/18
NO CHANGE
JPMS
Overweight
JPMorgan views Eidos Therapeutics selloff on Pfizer data as overdone
JPMorgan analyst Anupam Rama views this morning's selloff in shares of Eidos Therapeutics (EIDX) following the data from Pfizer (PFE) as overdone. The stock in early trading is down 33%, or $6.65, to $13.58. The Tafamidis Phase 3 Transthyretin Cardiomyopathy study from Pfizer "leaves plenty of room for mortality improvement" for Eidos Therapeutics' AG10, Rama tells investors in a research note. He believes the weakness in Eidos is overdone based on the totality of the data presented at the ESC Congress and in the New England Journal of Medicine. Eidos has "plenty of catalysts on the horizon" that can help validate AG10, Rama contends. The analyst keeps an Overweight rating on the shares.
10/31/18
ROTH
10/31/18
INITIATION
Target $28
ROTH
Buy
Eidos Therapeutics initiated with a Buy at Roth Capital
Roth Capital analyst Yasmeen Rahimi started Eidos Therapeutics with a Buy rating and $28 price target. The analyst notes that the company's Phase 2 results are anticipated at the AHA meeting on November 10, and views AG10 as a best-in-class transthyretin stabilizer for treatment of ATTR-CM.
10/31/18
10/31/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. CVR Energy (CVI) initiated with a Buy at Citi. 2. Cheniere Energy (LNG) reinstated with an Overweight at JPMorgan. 3. Eidos Therapeutics (EIDX) initiated with a Buy at Roth Capital. 4. NV5 Global (NVEE) and GSE Systems (GVP) were initiated with a Buy at Maxim. 5. Nexa Resources (NEXA) initiated with an Outperform at National Bank. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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