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JNCE

Jounce Therapeutics

$4.82

-0.07 (-1.43%)

13:15
11/11/18
11/11
13:15
11/11/18
13:15

Jounce Therapeutics presents data from ICOS program at SITC annual meeting

Jounce Therapeutics announced that reverse translational and biomarker data derived from its ICONIC trial of JTX-2011 and preclinical data from the ICOS program were presented at the Society for Immunotherapy of Cancer's 33rd Annual Meeting, being held November 9-11, 2018 in Washington, D.C. Data presented from ICONIC patients demonstrate the agonistic properties of JTX-2011. These data are in addition to the subset analysis data presented at ASCO 2018 demonstrating the emergence of ICOS hi CD4 T cells in the bloodstream in all patients with greater than or equal to 30% target lesion tumor reductions, both in patients treated with JTX-2011 monotherapy and in combination with nivolumab. The ICOS hi CD4 T cells were not observed in patients with primary progressive disease. Follow-up on the initial observation of the emergence of ICOS hi CD4 T cells. Emergence of this cell population, which correlated with clinical benefit in patients treated with both JTX-2011 monotherapy and in combination with nivolumab, was presented at ASCO in June 2018. These data build upon the initial observation and provides further characterization of the emerging cell population as T effector and not T regulatory cells and includes evidence that the cells do not emerge in patients responding to PD-1 monotherapy. Additional in vitro data presented demonstrate that JTX-2011 alone induces a cytokine response from CD4 T cells, only if the T cells have pre-existing ICOS hi characteristics. CTLA-4 inhibition has been shown to induce a population of ICOS hi cells in the bloodstream, while PD-1 inhibitors do not, and these observations further support the biological rationale for the ongoing clinical development of JTX-2011 in combination with ipilimumab. The combination of radiation therapy and treatment with an ICOS agonist antibody led to increased anti-tumor response in an immunogenic mouse tumor model. In a less immunogenic tumor model, response required the combination of ICOS agonist and PD-1 antagonist with radiation, suggesting again that ICOS agonism in combination with modalities that upregulate ICOS, such as with radiation, may represent an attractive regimen for combination immunotherapy of anti-PD-1 resistant tumors.

  • 13

    Nov

  • 13

    Nov

JNCE Jounce Therapeutics
$4.82

-0.07 (-1.43%)

06/04/18
06/04/18
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Big Lots (BIG) downgraded to Hold from Buy at Loop Capital with analyst Anthony Chukumba saying the company got off to a "tough start in fiscal 2018 with a store sales decline and continued slowdown in furniture sales." 2. Jounce Therapeutics (JNCE) downgraded to Neutral from Overweight at JPMorgan with analyst Cory Kasimov saying he views the company's ASCO data as disappointing. 3. MetLife (MET) downgraded to Neutral from Buy at Goldman Sachs with analyst Alex Scott saying he see slower progress towards return on equity improvement and believes some of the upside from capital return acceleration is behind the company at this point. 4. Dollar Tree (DLTR) downgraded to Accumulate from Buy at Gordon Haskett. 5. SM Energy (SM) downgraded to Neutral from Outperform at Credit Suisse with analyst Betty Jiang saying she believes SM Energy's discount valuation is appropriate given it has greater than average downside risk in a constrained Permian takeaway environment. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
06/05/18
COWN
06/05/18
DOWNGRADE
COWN
Market Perform
Jounce Therapeutics downgraded to Market Perform from Outperform at Cowen
06/28/18
RAJA
06/28/18
INITIATION
Target $13
RAJA
Outperform
Jounce Therapeutics initiated with an Outperform at Raymond James
Raymond James analyst Steven Seedhouse initiated Jounce Therapeutics with an Outperform and $13 price target.
08/13/18
HCWC
08/13/18
NO CHANGE
Target $13
HCWC
Buy
Jounce Therapeutics price target lowered to $13 from $19 at H.C. Wainwright
H.C. Wainwright analyst Debjit Chattopadhyay lowered his price target for Jounce Therapeutics to $13 but keeps a Buy rating on the shares. The analyst sees limited near-term catalysts to drive investor sentiment, and he believes there remains "substantial clinical questions that need to be addressed before ICOS agonism comes back to the fore."

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