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CRVS

Corvus Pharmaceuticals

$7.95

-0.03 (-0.38%)

13:33
11/11/18
11/11
13:33
11/11/18
13:33

Corvus Pharmaceuticals announces updated results from CPI-444, CPI-006

Corvus Pharmaceuticals announced updated clinical and biomarker data from ongoing Phase 1/1b studies of its lead programs, CPI-444 and CPI-006. Updated results from its Phase 1/1b clinical trial of CPI-444 in patients with treatment-refractory renal cell carcinoma demonstrated an overall survival of 88% at more than 20 months follow-up with CPI-444 administered in combination with atezolizumab. The clinical data were presented in an oral session at the Society for Immunotherapy of Cancer's 33rd Annual Meeting in Washington, D.C. Additionally, CPI-444 biomarker data from the Phase 1/1b study showing that expression of a novel adenosine gene signature was significantly associated with tumor regression were presented both in the oral presentation and in a poster session at the SITC meeting. Early clinical data from an ongoing Phase 1/1b study evaluating CPI-006 as a monotherapy showing evidence of immune activation of B cells were presented in a poster session. CPI-444, Corvus' lead product candidate, is a selective and potent inhibitor of the adenosine A2A receptor. It is currently being evaluated in Phase 1/1b and 1b/2 clinical trials in patients with various solid tumors as a monotherapy and in combination with Genentech's atezolizumab, an anti-PD-L1 antibody. CPI-006 is a humanized monoclonal antibody directed against CD73. It is currently being evaluated in a Phase 1/1b three-arm clinical trial in patients with a variety of solid tumors as a monotherapy, in combination with CPI-444, and in combination with pembrolizumab, an anti-PD-1 antibody. CPI-444 continues to be well tolerated to date, with observed adverse events similar to previous reports. In the combination arm, adverse events were generally consistent with other anti-PD-L1 therapies. In the monotherapy arm, grade 3 adverse events were infrequent and reversible.

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CRVS Corvus Pharmaceuticals
$7.95

-0.03 (-0.38%)

06/05/18
JEFF
06/05/18
INITIATION
Target $17
JEFF
Buy
Corvus Pharmaceuticals initiated with a Buy at Jefferies
Jefferies analyst Biren Amin started Corvus Pharmaceuticals with a Buy rating and $17 price target. The analyst views CPI-444 as a potentially interesting immuno-oncology asset in non-small cell lung cancer and renal cell carcinoma.
08/15/18
FBCO
08/15/18
UPGRADE
FBCO
Outperform
Corvus Pharmaceuticals upgraded to Outperform from Neutral at Credit Suisse
08/15/18
08/15/18
UPGRADE
Target $15

Outperform
Corvus Pharmaceuticals upgraded to Outperform at Credit Suisse
As previously reported, Credit Suisse analyst Michael Morabito upgraded Corvus Pharmaceuticals to Outperform from Neutral and raised the stock's price target to $15 from $11 after assuming coverage of the name. The analyst believes the company's lead product, CPI-444, has a clear lead in the clinic compared to competitors, and looks like a compelling treatment for PD-1 refractory patients, a growing market with PD-1 therapy being used increasingly in first-line settings.

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