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MESO

Mesoblast

$7.75

0.34 (4.59%)

20:22
11/11/18
11/11
20:22
11/11/18
20:22

Mesoblast announces clinically meaningful outcome in NIH trial of MPC-150-IM

Mesoblast announced that results from a 159-patient randomized, sham-controlled Phase 2 trial in end-stage heart failure patients implanted with a left ventricular assist device showed that Mesoblast's allogeneic cell therapy candidate MPC-150-IM achieved significant reduction in major gastrointestinal bleeding episodes and related hospitalizations, a complication affecting up to 40% of LVAD recipients. This clinically meaningful outcome confirms results seen in an earlier 30-patient pilot trial which provided the basis for the Regenerative Medicine Advanced Therapy designation granted to Mesoblast by the United States Food and Drug Administration for MPC-150-IM as adjunctive therapy to LVAD implantation. Under the RMAT designation, Mesoblast received specific guidance from the FDA that reduction in major GI bleeding episodes and related hospitalizations in the current trial is a clinically meaningful outcome with a high unmet need that could meet requirements for an approvable regulatory endpoint. In contrast, the FDA advised that the primary endpoint in the current trial of temporary weaning from full LVAD support is considered a biomarker and is not a clinically meaningful outcome in and of itself. MPC-150-IM is also being evaluated by catheter-based delivery in patients with NYHA Class IIb-III CHF. This ongoing events-driven Phase 3 trial has enrolled approximately 85% of approximately 600 total patients.

  • 11

    Nov

  • 12

    Nov

MESO Mesoblast
$7.75

0.34 (4.59%)

03/22/18
FBCO
03/22/18
DOWNGRADE
FBCO
Underperform
Mesoblast downgraded to Underperform from Neutral at Credit Suisse
03/22/18
03/22/18
DOWNGRADE
Target $6

Underperform
Mesoblast downgraded to Underperform at Credit Suisse
As previously reported, Credit Suisse analyst Alethia Young downgraded Mesoblast to Underperform from Neutral and lowered her price target on the shares to $6 from $11 due to slower launch timelines. The analyst is cautious into the upcoming LVAD advanced heart failure study, 12-month data in Q3.
06/07/18
HCWC
06/07/18
INITIATION
Target $17
HCWC
Buy
Mesoblast initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Jason Kolbert started Mesoblast with a Buy rating and $17 price target. The analyst sees Mesoblast as having the strongest pipeline in the regenerative medicine space.
07/18/18
MAXM
07/18/18
NO CHANGE
Target $16
MAXM
Buy
Mesoblast price target raised to $16 at Maxim on Tasly deal in China
Maxim analyst Jason McCarthy raised his price target on Mesoblast to $16 from $14 and kept his Buy rating. The analyst cites the company's announced partnership with Tasly Pharma in China for development of MPC-150-IM in chronic heart failure and MPC-25-IC in acute myocardial infarction, adding that market into his model. McCarthy further points to Mesoblast's improved balance sheet as a result of this "great" partnership.

TODAY'S FREE FLY STORIES

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BAE Systems

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Amazon.com

$1,696.01

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$1,696.01

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$213.59

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VNO

Vornado

$66.40

1.04 (1.59%)

, KRC

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$66.40

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$68.23

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  • 05

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GOLD

Barrick Gold

$11.78

-0.11 (-0.93%)

, GG

Goldcorp

$10.37

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  • 21

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TECH

Bio-Techne

$163.24

1.16 (0.72%)

, A

Agilent

$71.93

1.16 (1.64%)

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TECH

Bio-Techne

$163.24

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A

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ILMN

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ATVI

Activision Blizzard

$48.64

1.26 (2.66%)

, EA

Electronic Arts

$92.50

3.19 (3.57%)

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ATVI

Activision Blizzard

$48.64

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EA

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NFLX

Netflix

$339.20

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AIMT

Aimmune

$22.90

0.26 (1.15%)

, CELG

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$86.27

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CELG

Celgene

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BIIB

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CMRE

Costamare

$4.97

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DAC

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$0.90

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TGH

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$13.34

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NM

Navios Maritime

$2.73

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YRCM

Rogers Cantel

$0.00

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EXPD

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$69.34

1.43 (2.11%)

LEN

Lennar

$44.11

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KBH

KB Home

$20.30

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PHM

PulteGroup

$26.58

-0.27 (-1.01%)

Z

Zillow

$33.93

0.35 (1.04%)

ZG

Zillow

$33.74

0.35 (1.05%)

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Realogy

$18.27

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RDFN

Redfin

$18.49

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DDAIF

Daimler AG

$0.00

(0.00%)

FCAU

Fiat Chrysler

$16.78

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F

Ford

$8.59

0.23 (2.75%)

GM

General Motors

$38.63

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HMC

Honda

$29.77

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Nissan

$0.00

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TM

Toyota

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VLKAY

Volkswagen

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ASLN

Aslan Pharmaceuticals

$3.55

(0.00%)

, FPRX

Five Prime

$11.20

0.53 (4.97%)

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ASCO GI 2019 Symposium…

ASLN

Aslan Pharmaceuticals

$3.55

(0.00%)

FPRX

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$11.20

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KURA

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ZLAB

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$25.98

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04:55
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Deutsche Bank to hold a conference »

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TCCO

Technical Comm Corp

$2.61

-0.19 (-6.79%)

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Technical Comm Corp reports notice of failure to satisfy Nasdaq rule »

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SNAP

Snap

$6.19

0.455 (7.93%)

17:38
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Snap exec fired due to undisclosed relationship with consultant, Cheddar says »

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  • 24

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SSW

Seaspan

$9.16

0.16 (1.78%)

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TXT

Textron

$49.38

0.75 (1.54%)

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Textron subsidiary awarded $439.56M government contract modification »

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  • 24

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TAC

TransAlta

$4.91

0.04 (0.82%)

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Mangrove Partners reports 9.4% passive stake in TransAlta »

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TDS

Telephone and Data

$36.27

0.42 (1.17%)

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Telephone and Data's Meyers sells 80,465 common shares »

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GWPH

GW Pharmaceuticals

$137.24

2.59 (1.92%)

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Breaking Syndicate news story on GW Pharmaceuticals »

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FCSC

Fibrocell Science

$2.03

0.03 (1.50%)

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Breaking Syndicate news story on Fibrocell Science »

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ENLC

EnLink Midstream

$11.75

0.4 (3.52%)

, ENLK

EnLink Midstream Partners

$13.58

0.51 (3.90%)

16:49
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Conference/Events
EnLink Midstream Partners to hold a special shareholder meeting »

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ENLC

EnLink Midstream

$11.75

0.4 (3.52%)

ENLK

EnLink Midstream Partners

$13.58

0.51 (3.90%)

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  • 23

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FDX

FedEx

$176.97

3.72 (2.15%)

16:49
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ENLK

EnLink Midstream Partners

$13.58

0.51 (3.90%)

, ENLC

EnLink Midstream

$11.75

0.4 (3.52%)

16:48
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01/18
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Conference/Events
EnLink Midstream Companies to hold a special shareholder meeting »

Special Shareholder…

ENLK

EnLink Midstream Partners

$13.58

0.51 (3.90%)

ENLC

EnLink Midstream

$11.75

0.4 (3.52%)

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  • 23

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MKL

Markel

$1,067.03

13.52 (1.28%)

16:36
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NILSY

Norilsk Nickel

$0.00

(0.00%)

16:35
01/18/19
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16:35
Downgrade
Norilsk Nickel rating change at Goldman Sachs »

Norilsk Nickel downgraded…

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JNJ

Johnson & Johnson

$130.65

1.54 (1.19%)

, ABBV

AbbVie

$89.51

2.28 (2.61%)

16:33
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AbbVie (ABBV) announced…

JNJ

Johnson & Johnson

$130.65

1.54 (1.19%)

ABBV

AbbVie

$89.51

2.28 (2.61%)

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FOMX

Foamix

$3.70

-0.14 (-3.65%)

16:32
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16:32
Conference/Events
Foamix to host research and development day »

Research and Development…

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