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ZYME

Zymeworks

$13.04

-0.2 (-1.51%)

06:33
11/14/18
11/14
06:33
11/14/18
06:33

Zymeworks updates clinical data for ZW25 anti-tumor candidate

Zymeworks presented updated ZW25 clinical data from the ongoing multi-center Phase 1 study which showed single agent ZW25, a bispecific antibody, induced anti-tumor activity and was well tolerated in heavily pretreated patients with a variety of HER2-expressing cancers. Of the 17 patients, eight had gastroesophageal cancers, four had colorectal cancer and five had other HER2-expressing cancers including gall bladder, cholangiocarcinoma, cervical, fallopian tube and salivary gland. The overall disease control rate, which includes patients with partial responses and stable disease was 82%. There were seven partial responses, seven stable disease and three progressive disease. The median progression-free survival in all 24 patients was 6.21 months. In the eight gastroesophageal cancer patients, who had a median of four prior systemic treatments, the response rate was 50%. In the four colorectal and five other HER2-expressing cancer patients the response rate was 33%. In the study, ZW25 was well tolerated. All treatment-related adverse events were Grade 1 or 2 with the exception of one patient with Grade 3 fatigue, and no treatment-related serious adverse events were seen.

ZYME Zymeworks
$13.04

-0.2 (-1.51%)

08/02/18
SBSH
08/02/18
UPGRADE
Target $20
SBSH
Buy
Citi upgrades Zymeworks to Buy on valuation
Citi analyst Yigal Nochomovitz upgraded Zymeworks to Buy from Neutral and raised his price target for the shares to $20 from $19. The company is well capitalized following the June offering with a cash runway expected to last through at least one planned Phase 2/3 registrational study for ZW-25, Nochomovitz tells investors in a research note. The analyst cites valuation for his upgrade to Buy.
08/02/18
SBSH
08/02/18
UPGRADE
Target $20
SBSH
Buy
Zymeworks upgraded to Buy from Neutral at Citi
Citi analyst Yigal Nochomovitz upgraded Zymeworks to Buy and raised his price target for the shares to $20 from $19.
06/06/18
06/06/18
NO CHANGE

Zymeworks files to sell $85M in common stock
Citigroup Global Markets Canada Inc. and Wells Fargo Securities, LLC are acting as joint book-running managers for the Offering. Raymond James Ltd. is acting as passive bookrunner and Paradigm Capital Inc. is acting as co-manager. MTS Securities, LLC served as financial advisor to Zymeworks in the offering.
06/06/18
SBSH
06/06/18
DOWNGRADE
Target $20
SBSH
Neutral
Zymeworks downgraded to Neutral from Buy at Citi
Citi analyst Yigal Nochomovitz downgraded Zymeworks to Neutral while raising his price target for the shares to $20 from $18. The analyst believes the good ZW25 data at ASCO are now reflected in the valuation. Further, he sees a lack of near-term share catalysts.

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