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MRK

Merck

$74.62

-0.06 (-0.08%)

06:48
11/14/18
11/14
06:48
11/14/18
06:48

Merck: Phase 3 KEYNOTE-181 trial met a primary endpoint of overall survival

Merck announced that the Phase 3 KEYNOTE-181 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, as monotherapy in the second-line treatment of advanced or metastatic esophageal or esophagogastric junction carcinoma has met a primary endpoint of overall survival in patients whose tumors expressed PD-L1. In this pivotal study, treatment with KEYTRUDA resulted in a statistically significant improvement in OS compared to chemotherapy (paclitaxel, docetaxel or irinotecan) in patients with CPS greater than or equal to10, regardless of histology. The primary endpoint of OS was also evaluated in patients with squamous cell histology and in the entire intention-to-treat study population. While directionally favorable, statistical significance for OS was not met in these two patient groups. Per the statistical analysis plan, the key secondary endpoints of progression-free survival and objective response rate were not formally tested, as OS was not reached in the full ITT study population. The safety profile of KEYTRUDA in this trial was consistent with that observed in previously reported studies. Results will be presented at an upcoming medical meeting and will be submitted to regulatory authorities worldwide.

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    Feb

MRK Merck
$74.62

-0.06 (-0.08%)

11/06/18
PIPR
11/06/18
NO CHANGE
Target $3
PIPR
Overweight
OncoSec price target lowered to $3 from $5 at Piper Jaffray
After OncoSec (ONCS) reported preliminary Phase 2b KEYNOTE-695 data for Tavo combined with Merck's (MRK) Keytruda in PD-1 refractory melanoma patients, Piper Jaffray analyst Edward Tenthoff said the data, while early, show evidence of clinical activity, adding that he believes duration of response data will be important. However, OncoSec shares are down 52% today, which Tenthoff attributes to the lower response rate compared to prior data in different patients. The analyst keeps an Overweight rating on OncoSec shares, but lowered his price target on the stock to $3 from $5 as he pushed out his approval projections for Tavo by one year in the U.S. and Europe.
10/31/18
SBSH
10/31/18
NO CHANGE
Target $84
SBSH
Buy
Merck price target raised to $84 from $79 at Citi
Citi analyst Andrew Baum raised his price target for Merck to $84 and reiterates a Buy rating on the shares. The analyst says his 20%-plus above consensus non-GAAP earnings estimates beyond 2022 are driven by a continued view that the market underestimates Merck's market share in the PDx and PARP spaces with Keytruda and Lynparza respectively.
10/25/18
WELS
10/25/18
NO CHANGE
WELS
Wells Fargo says Trump speech today won't be end of drug pricing proposals
Wells Fargo analyst David Maris notes that Politico and other media outlets are reporting that President Donald Trump will propose several new initiatives to address high drug prices when he speaks later today at the U.S. Department of Health and Human Services. Maris thinks Trump's focus will be on how other countries are "freeloading" on U.S. innovation with lower negotiated pricing, stating that news reports make it appear that the administration is targeting the industry for action, rather than other countries to raise their spending. While Maris acknowledges the timing of the speech being near the mid-term elections, he believes these proposals are simply the follow-though of earlier promises. He also expects this is not the end of proposals to address the issue of U.S. drug pricing. Publicly traded large-cap drugmakers include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).
10/23/18
WOLF
10/23/18
INITIATION
Target $90
WOLF
Outperform
Merck reinitiated with an Outperform at Wolfe Research
Wolfe Research analyst Time Anderson reinitiated Merck with an Outperform and $66 price target.

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MYGN

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2.14 (9.22%)

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Cisco

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RDS.A

Royal Dutch Shell

$55.55

0.47 (0.85%)

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Royal Dutch Shell

$55.55

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Royal Dutch Shell

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BP

BP

$36.27

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Exxon Mobil

$68.30

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CVX

Chevron

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TGT

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WMT

Walmart

$112.99

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Grocery Outlet

$46.55

2.81 (6.42%)

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AEO

American Eagle

$15.40

0.63 (4.27%)

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ANGI

Angi Homeservices

$8.18

-0.18 (-2.15%)

, MTCH

Match Group

$84.53

2.08 (2.52%)

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MTCH

Match Group

$84.53

2.08 (2.52%)

IAC

IAC

$249.17

4.21 (1.72%)

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AAPL

Apple

$206.44

4.71 (2.33%)

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Hasbro

$114.29

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$206.44

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Hasbro

$114.29

1.13 (1.00%)

MAT

Mattel

$10.74

(0.00%)

AGR

Avangrid

$49.29

0.37 (0.76%)

JPM

JPMorgan

$107.73

2.52 (2.40%)

BAC

Bank of America

$27.04

0.79 (3.01%)

C

Citi

$63.46

2.13 (3.47%)

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NCLH

Norwegian Cruise Line

$50.48

1.38 (2.81%)

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Norwegian Cruise Line CEO sells 25K shares of common stock »

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RM

Regional Management

$27.12

0.14 (0.52%)

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RTN

Raytheon

$178.10

-0.42 (-0.24%)

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WEN

Wendy's

$19.94

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  • 13

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BRY

Berry Petroleum

$8.59

0.39 (4.76%)

17:54
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CSWI

CSW Industrials

$70.20

1.92 (2.81%)

17:52
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CSW Industrials CEO sells 25K shares of common stock »

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OAS

Oasis Petroleum

$3.03

0.135 (4.66%)

17:49
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Oasis Petroleum CEO buys 30K shares of common stock »

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EE

El Paso Electric

$66.41

0.005 (0.01%)

17:45
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El Paso Electric director Wertheimer sells 25K shares of common stock »

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HON

Honeywell

$165.07

2.81 (1.73%)

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MBRX

Moleculin Biotech

$1.08

0.01 (0.93%)

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VIVE

Viveve

$0.13

0.0046 (3.59%)

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Breaking Syndicate news story on Viveve »

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PRGO

Perrigo

$46.21

0.535 (1.17%)

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  • 01

    Oct

UAL

United Continental

$82.96

1.36 (1.67%)

17:28
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United Continental director Shapiro buys 10K shares of common stock »

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MBIO

Mustang Bio

$3.88

0.19 (5.15%)

17:26
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Breaking Syndicate news story on Mustang Bio »

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  • 04

    Sep

BCLI

BrainStorm

$3.63

0.055 (1.54%)

17:24
08/16/19
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Syndicate
Breaking Syndicate news story on BrainStorm »

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WLK

Westlake Chemical

$61.27

0.66 (1.09%)

17:15
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Hot Stocks
Westlake Chemical raises quarterly dividend by 5% to 26.25c per share »

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GIG

GigCapital

$10.30

(0.00%)

17:10
08/16/19
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Hot Stocks
GigCapital receives noncompliance notice from NYSE »

GigCapital announced that…

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