Breaking News Instant updates and real-time market news.

MGNX

MacroGenics

$16.82

0.21 (1.26%)

07:34
11/14/18
11/14
07:34
11/14/18
07:34

MacroGenics presents data on PD-L1 x CD137 DART program at symposium

MacroGenics announced that it had presented a poster at the EORTC-NCI-AACR Symposium. PD-1/PD-L1 blockade is a clinically proven cancer therapeutic strategy that releases an inhibitory brake on T-cell activation. Co-stimulation by CD137, also known as 4-1BB, has been shown to synergistically increase the activity of PD-1/PD-L1 axis blockade. Clinical application of such a combination approach, however, may be limited by toxicity associated with the systemic administration of CD137 agonists. Bispecific antibody targeting strategies afford the feasibility of localizing CD137 co-stimulation to the tumor microenvironment through simultaneous engagement of a tumor-expressed antigen and CD137 expressed on tumor infiltrating lymphocytes. In this poster, MacroGenics demonstrated that bispecific DART or TRIDENT proteins constructed using a proprietary PD-L1 blocking monoclonal antibody, or mAb, and a CD137-engaging mAb can further extend immune cell activation observed by concomitant PD-1/PD-L1 axis blockade and CD137 co-stimulation beyond that achieved by the combination of individual mAbs. The preclinical data presented show that PD-L1 x CD137 bispecific DART and TRIDENT molecules can switch on CD137 co-stimulation strictly in a PD-L1-dependent fashion, limiting the probability of systemic activation where PD-L1 is not expressed. Although tumor adaptive resistance via PD-L1 induction promotes immune escape, PD-L1 x CD137 bispecific molecules can exploit the upregulation of the checkpoint ligand to provide a co-stimulatory signal and further amplify concomitant checkpoint blockade. Additional investigations as a potential therapeutic approach to overcome limitations of existing PD-1/PD-L1-targeting strategies are ongoing.

  • 03

    Dec

MGNX MacroGenics
$16.82

0.21 (1.26%)

09/10/18
BTIG
09/10/18
INITIATION
Target $30
BTIG
Buy
MacroGenics assumed with a Buy at BTIG
BTIG analyst Thomas Shrader assumed MacroGenics with a Buy rating and a price target if $30, saying he is positive on its DART and TRIDENT multi-functional antibodies programs and its Fc Optimization technology that "allows antibodies to interact more strongly with immune effector cells that resolve antibody-antigen complexes". The analyst contends that while the company's monoclonal antibodies, or mAb, development space is "crowded", MacroGenics offers "nearly two decades of tough won experience" and over two years of cash runway to give its "deep pipeline" multiple opportunities to "turn heads".
05/31/18
EVER
05/31/18
INITIATION
Target $33
EVER
Outperform
MacroGenics initiated with an Outperform at Evercore ISI
Evercore ISI initiated MacroGenics with an Outperform and $33 price target.
04/06/18
LEER
04/06/18
INITIATION
Target $35
LEER
Outperform
MacroGenics assumed with an Outperform at Leerink
Leerink analyst Jonathan Chang assumed coverage of MacroGenics with an Outperform rating and $35 price target. The analyst views bispecific antibodies as a promising drug class and believes MacroGenics has one of the broadest and deepest pipelines of proprietary and partnered bispecific antibodies in clinical development. He has a positive view on the stock ahead of "multiple clinical catalysts" expected in 2018/2019.
03/05/18
03/05/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Alta Mesa Resources (AMR) initiated with an Outperform at Imperial Capital. 2. Cactus (WHD) was initiated with an Overweight at Barclays, Piper Jaffray, and JPMorgan, an Outperform at Credit Suisse and a Buy at BofA/Merrill. 3. Victory Capital (VCTR) was initiated with an Overweight at Barclays, Morgan Stanley and JPMorgan, an Outperform at William Blair and RBC Capital, a Market Perform at Keefe Bruyette, a Buy at BofA/Merrill, a Neutral at Goldman Sachs, as well as a Hold at Sandler O'Neill. 4. Evolus (EOLS) was initiated with an Overweight at Cantor Fitzgerald, an Outperform at JMP Securities and a Buy at Mizuho and SunTrust. 5. MacroGenics (MGNX) initiated with a Buy at H.C. Wainwright. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

03:25
08/21/19
08/21
03:25
08/21/19
03:25
General news
FX Action: USD-CAD yesterday matched the two-month high »

FX Action: USD-CAD…

02:55
08/21/19
08/21
02:55
08/21/19
02:55
General news
FX Update: The main currencies have been steady »

FX Update: The main…

02:10
08/21/19
08/21
02:10
08/21/19
02:10
General news
Asian Market Wrap: »

Asian Market Wrap:…

HA

Hawaiian Holdings

$25.44

0.31 (1.23%)

21:12
08/20/19
08/20
21:12
08/20/19
21:12
Downgrade
Hawaiian Holdings rating change at Stifel »

Hawaiian Holdings…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 04

    Sep

  • 05

    Sep

MHK

Mohawk

$112.98

-1.05 (-0.92%)

21:06
08/20/19
08/20
21:06
08/20/19
21:06
Upgrade
Mohawk rating change at Wells Fargo »

Mohawk upgraded to Market…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SNV

Synovus

$35.18

-0.78 (-2.17%)

21:01
08/20/19
08/20
21:01
08/20/19
21:01
Initiation
Synovus initiated at DA Davidson »

Synovus initiated with a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 27

    Aug

  • 28

    Aug

  • 29

    Aug

  • 23

    Sep

BXS

BancorpSouth

$27.49

-0.415 (-1.49%)

20:59
08/20/19
08/20
20:59
08/20/19
20:59
Initiation
BancorpSouth initiated at DA Davidson »

BancorpSouth initiated…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 26

    Aug

UCBI

United Community Banks

$26.63

-0.36 (-1.33%)

20:57
08/20/19
08/20
20:57
08/20/19
20:57
Initiation
United Community Banks initiated at DA Davidson »

United Community Banks…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 16

    Sep

  • 17

    Sep

RNST

Renasant

$33.20

-0.375 (-1.12%)

20:57
08/20/19
08/20
20:57
08/20/19
20:57
Initiation
Renasant initiated at DA Davidson »

Renasant initiated with a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Sep

FCCO

First Community

$18.31

(0.00%)

20:57
08/20/19
08/20
20:57
08/20/19
20:57
Initiation
First Community initiated at DA Davidson »

First Community initiated…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

20:25
08/20/19
08/20
20:25
08/20/19
20:25
Conference/Events
Cantor Fitzgerald tech analyst to hold an analyst/industry conference call »

Technology & Business…

LOW

Lowe's

$98.04

3.07 (3.23%)

, TGT

Target

$85.57

-0.34 (-0.40%)

20:25
08/20/19
08/20
20:25
08/20/19
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

LOW

Lowe's

$98.04

3.07 (3.23%)

TGT

Target

$85.57

-0.34 (-0.40%)

ADI

Analog Devices

$110.35

-0.8 (-0.72%)

PLCE

Children's Place

$78.06

-2.6 (-3.22%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 21

    Aug

  • 21

    Aug

  • 21

    Aug

  • 21

    Aug

  • 15

    Sep

  • 19

    Sep

  • 25

    Sep

GOOG

Alphabet

$1,183.43

-14.58 (-1.22%)

, GOOGL

Alphabet Class A

$1,184.26

-15.68 (-1.31%)

19:02
08/20/19
08/20
19:02
08/20/19
19:02
Periodicals
YouTube intends to end targeted ads on videos aimed at children, Bloomberg says »

In an effort to satisfy…

GOOG

Alphabet

$1,183.43

-14.58 (-1.22%)

GOOGL

Alphabet Class A

$1,184.26

-15.68 (-1.31%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Sep

  • 27

    Oct

HMNY

Helios and Matheson

$0.00

(0.00%)

18:59
08/20/19
08/20
18:59
08/20/19
18:59
Periodicals
MoviePass exposed card data of thousands of customers, TechCrunch says »

MoviePass, which is…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

PLM

PolyMet Mining

$0.34

-0.0125 (-3.60%)

18:49
08/20/19
08/20
18:49
08/20/19
18:49
Hot Stocks
PolyMet Mining reports court declined to hear petition for environmental review »

Poly Met Mining inc., a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

AAL

American Airlines

$25.83

-0.27 (-1.03%)

18:24
08/20/19
08/20
18:24
08/20/19
18:24
Hot Stocks
American Airlines to pay $22.1M to settle DOJ false claims act allegations »

The U.S. Justice…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 04

    Sep

  • 05

    Sep

  • 23

    Sep

  • 14

    Nov

LZB

La-Z-Boy

$30.55

-1.325 (-4.16%)

, URBN

Urban Outfitters

$20.93

0.07 (0.34%)

18:17
08/20/19
08/20
18:17
08/20/19
18:17
Hot Stocks
Fly Intel: After Hours Movers »

UP AFTER EARNINGS:…

LZB

La-Z-Boy

$30.55

-1.325 (-4.16%)

URBN

Urban Outfitters

$20.93

0.07 (0.34%)

LEDS

SemiLEDs

$2.22

-0.05 (-2.20%)

NRZ

New Residential

$14.14

-0.115 (-0.81%)

NDSN

Nordson

$135.43

-1.79 (-1.30%)

CREE

Cree

$58.19

-0.09 (-0.15%)

SCSC

Scansource

$31.23

-0.56 (-1.76%)

JKHY

Jack Henry

$140.79

-0.72 (-0.51%)

TSLA

Tesla

$225.70

-1.05 (-0.46%)

WMT

Walmart

$112.12

-1.64 (-1.44%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 20

    Aug

  • 20

    Aug

  • 20

    Aug

  • 21

    Aug

  • 21

    Aug

  • 21

    Aug

  • 22

    Aug

  • 27

    Aug

  • 09

    Sep

  • 11

    Sep

  • 12

    Sep

  • 15

    Sep

  • 19

    Sep

  • 23

    Sep

  • 25

    Sep

  • 13

    Nov

  • 14

    Nov

LEDS

SemiLEDs

$2.22

-0.05 (-2.20%)

18:06
08/20/19
08/20
18:06
08/20/19
18:06
Hot Stocks
SemiLEDs receives offer from Chinese investor to acquire 680K shares »

On August 17, 2019,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

CE

Celanese

$111.76

-0.72 (-0.64%)

18:01
08/20/19
08/20
18:01
08/20/19
18:01
Hot Stocks
Celanese announces ethyl acetate price increase in Europe »

Celanese Corporation…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

WMT

Walmart

$112.12

-1.64 (-1.44%)

17:50
08/20/19
08/20
17:50
08/20/19
17:50
Hot Stocks
Walmart's Furner sells nearly 8,000 common shares »

In a regulatory filing,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Sep

  • 25

    Sep

  • 13

    Nov

  • 14

    Nov

SPY

SPDR S&P 500 ETF Trust

$290.03

-2.28 (-0.78%)

, SPX

S&P 500

$0.00

(0.00%)

17:49
08/20/19
08/20
17:49
08/20/19
17:49
Periodicals
Bond manager Gundlach says Fed 'has lost control,' Reuters reports »

According to often quoted…

SPY

SPDR S&P 500 ETF Trust

$290.03

-2.28 (-0.78%)

SPX

S&P 500

$0.00

(0.00%)

QQQ

Invesco QQQ Trust

$186.99

-1.3 (-0.69%)

DIA

Diamonds Fund ETF

$259.61

-1.71 (-0.65%)

SMH

Market Vectors Semiconductor

$113.43

-0.64 (-0.56%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

URBN

Urban Outfitters

$20.93

0.07 (0.34%)

17:45
08/20/19
08/20
17:45
08/20/19
17:45
Earnings
Urban Outfitters CEO says Q2 was 'difficult quarter' for the company »

Urban Outfitter CEO…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 20

    Aug

  • 22

    Aug

  • 25

    Sep

17:45
08/20/19
08/20
17:45
08/20/19
17:45
General news
Breaking General news story  »

Federal Reserve Board of…

BA

Boeing

$331.94

-1.82 (-0.55%)

17:41
08/20/19
08/20
17:41
08/20/19
17:41
Hot Stocks
Boeing awarded $154.89M Army contract modification to procure Apache helicopters »

Boeing was awarded a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 03

    Sep

CGC

Canopy Growth

$27.21

0.48 (1.80%)

17:35
08/20/19
08/20
17:35
08/20/19
17:35
Hot Stocks
GTEC provides update on acquisition of Canopy Growth cultivation facility »

GTEC Holdings provided an…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.