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RDHL

RedHill Biopharma

$9.15

0.39 (4.45%)

08:12
11/14/18
11/14
08:12
11/14/18
08:12

RedHill Biopharma to present Yeliva data at EORTC-NCI-AACR Symposium

RedHill Biopharma announced a poster presentation on Yeliva for multiple myeloma at the upcoming EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. The abstract describes data from preclinical studies and a Phase Ib/II study with Yeliva for the treatment of multiple myeloma. The open-label, dose escalation Phase Ib/II study evaluating Yeliva in patients with refractory or relapsed multiple myeloma that were previously treated with proteasome inhibitors and immunomodulatory drugs is ongoing at Duke University Medical Center. Enrollment for the Phase Ib portion of the study has been completed with a total of 11 patients enrolled and treated in three dose cohorts. Results from the Phase Ib portion of the study did not show any dose-limiting toxicities. Additionally, while efficacy was not the primary endpoint of the Phase I study, it was observed that out of 10 evaluable subjects, two subjects had stable disease for over four months and one patient achieved a very good partial response, or VGPR. In addition, results from preclinical studies demonstrated that SK2 is overexpressed in multiple myeloma cell lines and in human multiple myeloma specimens and plays a critical role in myeloma cell growth, proliferation and survival. Additional preclinical studies described in the abstract demonstrated that treatment with Yeliva effectively inhibited myeloma tumor growth in vitro and in vivo in mouse xenograft models. The authors conclude that Yeliva as a single agent or in combination with a B-cell lymphoma 2 inhibitor has the potential for treatment of relapsed/refractory multiple myeloma patients that were previously treated with proteosome inhibitors and immunomodulatory agents. The Phase Ib/II study with Yeliva for multiple myeloma is supported by a $2M grant from the National Cancer Institute, or NCI, Small Business Innovation Research Program, or SBIR, awarded to Apogee Biotechnology in conjunction with Duke University, with additional support provided by RedHill.

RDHL RedHill Biopharma
$9.15

0.39 (4.45%)

01/26/18
NOMU
01/26/18
INITIATION
Target $18
NOMU
Buy
RedHill Biopharma initiated with a Buy at Nomura Instinet
Nomura Instinet analyst Chris Marai started RedHill Biopharma with a Buy rating and $18 price target. The analyst views the risk/reward as attractive ahead of catalysts in 2018.
01/26/18
01/26/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Williams Scotsman (WSC) initiated with an Outperform at Oppenheimer. 2. RedHill Biopharma (RDHL) initiated with a Buy at Nomura Instinet. 3. BioDelivery Sciences (BDSI) initiated with a Buy at Seaport Global. 4. NuStar GP Holdings (NSH) initiated with a Buy at B. Riley FBR. 5. Atara Biotherapeutics (ATRA) initiated with an Outperform at Cowen. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
06/25/18
LTCO
06/25/18
INITIATION
Target $20
LTCO
Buy
RedHill Biopharma initiated with a Buy at Ladenburg
Ladenburg analyst Matthew Kaplan initiated RedHill Biopharma with a Buy rating and $20 price target.
06/25/18
06/25/18
INITIATION
Target $20

Buy
RedHill Biopharma initiated with a Buy and $20 price target at Ladenburg
As previously reported, Ladenburg analyst Matthew Kaplan initiated RedHill Biopharma with a Buy rating and $20 price target, citing his focus on the company's portfolio of late-stage compounds. RHB-104, which is being developed for the treatment of Crohn's disease, could generate over $375M in U.S. revenues in 2030 while RHB-105 for the treatment of Helicobacter pylori infection could generate over $350M in peak U.S. revenues for this indication in 2027, Kaplan predicts.

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