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SRRK

Scholar Rock

$23.52

1.635 (7.47%)

07:20
11/27/18
11/27
07:20
11/27/18
07:20

Scholar Rock publishes data on inhibiting myostatin activation in models of SMA

Scholar Rock announced the publication, "Specific Inhibition of Myostatin Activation is Beneficial in Mouse Models of SMA Therapy" in the peer-reviewed journal Human Molecular Genetics. The publication details preclinical studies demonstrating that a highly specific inhibitor of myostatin activation effectively increased muscle mass and function in mouse models of Spinal Muscular Atrophy, or SMA. In addition, despite baseline serum levels of inactive latent myostatin being lower in the SMA mice than in mice without disease, successful target engagement was observed as evidenced by increased levels of latent myostatin in serum following treatment. Together, the results support the potential for myostatin blockade as a therapeutic strategy to address motor functional deficits in SMA.

SRRK Scholar Rock
$23.52

1.635 (7.47%)

06/18/18
WEDB
06/18/18
INITIATION
Target $25
WEDB
Outperform
Scholar Rock initiated with an Outperform at Wedbush
Wedbush analyst David Nierengarten started Scholar Rock with an Outperform rating and $25 price target saying it is taking a unique approach to inhibiting TGF beta, a key class of interest for drug developers but one considered too difficult to drug with specificity, by locking the proteins in their latent state. This strategy, and supportive preclinical data, give him confidence that the company's programs could be the first to safely shut down TGF beta signaling in a targeted manner, with application in several serious disorders.
06/18/18
BMOC
06/18/18
INITIATION
Target $31
BMOC
Outperform
Scholar Rock initiated with an Outperform at BMO Capital
BMO Capital analyst Do Kim initiated Scholar Rock with an Outperform rating and a price target of $31, citing his expectations of its proprietary research platform answering the challenges of modulating transforming growth factor beta signaling pathways. The analyst adds that the company's SRK-015 program has "properly aligned the drug's specific benefit to an ideal disease setting" and expects the Phase 1 data in Q4 to confirm its safety and PK/PD profile, with eventual proof-of-concept data coming in the second half of 2019.
06/18/18
JEFF
06/18/18
INITIATION
Target $26
JEFF
Buy
Scholar Rock initiated with a Buy at Jefferies
Jefferies analyst Michael Yee started Scholar Rock with a Buy rating and $26 price target. Similar to other orphan drug stories, early data could offer 50%-plus upside into 2019 if they show early benefit in spinal muscular atrophy patients, Yee tells investors in a research note.
06/18/18
COWN
06/18/18
INITIATION
Target $18
COWN
Outperform
Scholar Rock initiated with an Outperform at Cowen
Cowen analyst Ritu Baral initiated Scholar Rock with an Outperform rating as she believes its lead product, SRK-015, which is a myostatin activation inhibitor in development for SMA type 2 and 3, has significant clinical promise with peak potential U.S. sales of $1.6B. Baral has an $18 price target on Scholar Rock shares.

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