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ALNY

Alnylam

$74.28

-5.45 (-6.84%)

05:37
12/10/18
12/10
05:37
12/10/18
05:37

Alnylam announces settlement with Silence Therapeutics

Alnylam Pharmaceuticals announced that it has resolved all litigation worldwide with Silence Therapeutics. The settlement allows Alnylam to avoid the costs and distraction associated with continued litigation in multiple countries. Under terms of the global settlement, Silence will receive a low royalty on annual net sales of ONPATTRO in the EU only, with tiered royalties of 0.33 percent to 1.0 percent through 2023. Further terms of the agreement include the grant from Silence to Alnylam of a non-exclusive, global irrevocable, license to all relevant patents and for all current and future Alnylam products, whether commercialized by Alnylam or a collaborator or licensee. Such license is fully paid up with no milestones or royalties, except for the limited royalty on ONPATTRO net sales in the EU described above. Under the agreement, all ongoing court proceedings will be dismissed and each party will bear its own attorney fees and costs incurred in the global proceedings. Terms of the settlement, which includes no admissions by any party, are otherwise confidential.

ALNY Alnylam
$74.28

-5.45 (-6.84%)

12/07/18
PIPR
12/07/18
NO CHANGE
Target $160
PIPR
Overweight
Piper remains buyers of Alnylam following recent weakness
Alnylam Pharmaceuticals' R&D day highlighted the the transition into a commercial stage company with multiple late stage programs, Piper Jaffray analyst Edward Tenthoff tells investors in a research note. Alnylam is expanding RNAi drug discovery outside of the liver into central nervous system and cardiovascular disease, adds the analyst. He says Piper remains buyers of Alnylam on recent weakness ahead of new RNAi drug approvals and data read-outs. Tenthoff reiterates an Overweight rating on the stock with a $160 price target.
11/27/18
LEER
11/27/18
INITIATION
LEER
Leerink initiates select Genetic Medicine names on increasing regulatory clarity
Leerink analyst Mani Foroohar initiated select Genetic Medicine stocks, stating that the field is "is rich with companies developing drugs" to treat rare diseases and that he is increasingly more bullish on "innovation velocity and increasing regulatory clarity in the sector. Based on his "balanced view of pricing dynamics", the analyst issues an Outperform rating on Wave Life Sciences (WVE), Rocket Pharmaceuticals (RCKT), Intellia Therapeutics (NTLA), Eidos Therapeutics (EIDX), Dicerna (DRNA) and Bluebird Bio (BLUE). The analyst likes Wave Life Sciences as a pure play on Oligotherapeutics and its stereopure chemistry platform as a differentiated approach to oligo drug design. Foroohar is positive on Rocket Pharma's lead assets in gene therapies for Fanconi Anemia and Leukocyte Adhesion Deficiency-I "which will likely be the company's first potential approved product." The analyst is positive on Intellia Therapeutics' "robust balance sheet to support development, trading at a material discount to closest comps peers". For Eidos, the analyst cites the prospects of its drug candidate for TTR amyloidosis currently in a placebo-controlled Phase 2 study that may offer a competitive profile relative to Pfizer's (PFE) tafamidis. For Dicerna, Foroohar notes that its DCR-PHXC "is an RNAi therapeutic that targets lactate dehydrogenase A for the treatment of all subtypes of Primary Hyperoxaluria vs. competitor Alnylam's (ALNY) lumasiran, which only treats PH Type 1. For Bluebird Bio, the analyst is positive on its position as a "leader in ex vivo gene therapy, with four programs with visibility towards near-term regulatory approval". Foroohar initiates Avrobio (AVRO), Alnylam (ALNY), and Ionis Pharmaceuticals (IONS) with Market Perform rating based on competitive launches for their products along with "mixed" early signs of their results. The analyst also rates Regenxbio (RGNX) at underperform, saying that its "current valuation more than accounts for robust royalty streams from sales in spinal muscular atrophy" and other partnered assets.
11/27/18
LEER
11/27/18
INITIATION
Target $63
LEER
Market Perform
Alnylam initiated with a Market Perform at Leerink
Leerink analyst Mani Foroohar initiated Alnylam with a Market Perform rating and a price target of $63.
11/15/18
STFL
11/15/18
NO CHANGE
Target $111
STFL
Buy
Alnylam management 'exudes confidence' in TTR launch, says Stifel
After hosting a dinner with Alnylam CEO John Maraganore and the company's management, Stifel analyst Paul Matteis said management "exudes confidence" that Onpattro can penetrate a substantial portion of the diagnosed haTTR population while acknowledging that it takes a little time to convert "start forms" into paying commercial patients. Management also seems "completely at ease" ahead of the full readout of the givosiran phase 3 ENVISION data, said Matteis, who keeps a Buy rating and $111 price target on Alnylam shares.

TODAY'S FREE FLY STORIES

EFC

Ellington Financial

$18.79

0.01 (0.05%)

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ACY

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MYOV

Myovant Sciences

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INVH

Invitation Homes

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GBDC

Golub Capital

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0.045 (0.25%)

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GM

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$36.62

-0.25 (-0.68%)

, TM

Toyota

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CA to halt purchase of GM, Toyota, Fiat Chrysler vehicles, Reuters reports »

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GM

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TM

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FCAU

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NSANY

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CRMT

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$16.39

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CLVS

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NOW

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Okta

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3.76 (3.20%)

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KRNT

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ASH

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VNET

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DHT

DHT Holdings

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KRTX

Karuna Therapeutics

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EGHT

8x8, Inc.

$20.78

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I

Intelsat

$7.98

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PFGC

Performance Food Group

$46.09

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EFC

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$18.79

0.01 (0.05%)

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LEVI

Levi Strauss

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CSCO

Cisco

$45.17

0.07 (0.16%)

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ABBV

AbbVie

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  • 07

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PRQR

ProQR Therapeutics

$6.27

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BILI

Bilibili

$16.39

-0.32 (-1.92%)

18:04
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Earnings
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WUBA

58.com

$50.26

-1.35 (-2.62%)

18:03
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Earnings
58.com sees Q4 revenue up 12%-15% in RMB terms »

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BILI

Bilibili

$16.39

-0.32 (-1.92%)

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WUBA

58.com

$50.26

-1.35 (-2.62%)

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BILI

Bilibili

$16.39

-0.32 (-1.92%)

18:01
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Earnings
Bilibili reports Q3 adjusted EPS (15c), consensus (14c) »

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  • 18

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DDOG

Datadog

$40.36

-0.33 (-0.81%)

, AMZN

Amazon.com

$1,752.70

15.21 (0.88%)

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AMZN

Amazon.com

$1,752.70

15.21 (0.88%)

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Conference/Events
Morgan Stanley analyst to hold an analyst/industry conference call »

Managing Director &…

GVA

Granite Construction

$26.50

-0.6 (-2.21%)

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Granite Construction awarded $14M airfield improvement project in California »

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ZS

Zscaler

$44.46

-1.37 (-2.99%)

, MSFT

Microsoft

$150.35

0.4 (0.27%)

17:51
11/18/19
11/18
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17:51
Initiation
Zscaler, Microsoft initiated at DA Davidson »

Zscaler initiated with a…

ZS

Zscaler

$44.46

-1.37 (-2.99%)

MSFT

Microsoft

$150.35

0.4 (0.27%)

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OKTA

Okta

$121.21

3.76 (3.20%)

17:51
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11/18
17:51
11/18/19
17:51
Upgrade
Okta rating change at DA Davidson »

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PANW

Palo Alto Networks

$248.50

1.465 (0.59%)

17:48
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17:48
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17:48
Initiation
Palo Alto Networks initiated at DA Davidson »

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CRWD

Crowdstrike

$57.06

-2.73 (-4.57%)

, AMZN

Amazon.com

$1,752.70

15.21 (0.88%)

17:47
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11/18
17:47
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17:47
Initiation
Crowdstrike, Amazon.com initiated at DA Davidson »

Crowdstrike valuation…

CRWD

Crowdstrike

$57.06

-2.73 (-4.57%)

AMZN

Amazon.com

$1,752.70

15.21 (0.88%)

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