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ONCY

Oncolytics

$2.03

0.01 (0.50%)

, BMY

Bristol-Myers

$52.44

-0.15 (-0.29%)

07:10
12/12/18
12/12
07:10
12/12/18
07:10

Oncolytics treats first patient in pelareorep, carfilzomib with Opdivo trial

Oncolytics (ONCY) announced that the first patient was treated in a Phase 1 dose escalation study combining pelareorep and carfilzomib with Bristol-Myers (BMY) checkpoint inhibitor Opdivo to treat relapsed multiple myeloma patients. This study is based on findings from the NCI 9603 multiple myeloma study that combined pelareorep with carfilzomib that resulted in objective responses, elimination of multiple myeloma cells and most importantly, an inflamed phenotype with PD-L1 overexpression. This open-label, phase 1 study will enroll up to 62 patients to examine the side effects and best dosing schedule of pelareorep when given in combination with dexamethasone, carfilzomib, and nivolumab in treating participants with relapsed multiple myeloma. The primary objectives of the study are to determine the maximum tolerated dose of pelareorep in combination with carfilzomib and nivolumab. Secondary outcome measures include time to progression, progression-free survival and overall survival, as well as the characterization of an inflamed phenotype and confirmation of biomarker responses indicative of tumor inflammation.

ONCY

Oncolytics

$2.03

0.01 (0.50%)

BMY

Bristol-Myers

$52.44

-0.15 (-0.29%)

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ONCY Oncolytics
$2.03

0.01 (0.50%)

10/01/18
LTCO
10/01/18
INITIATION
Target $22
LTCO
Buy
Oncolytics initiated with a Buy at Ladenburg
Ladenburg Thalmann analyst Wangzhi Li started Oncolytics Biotech with a Buy rating and $22 price target. The analyst believes Oncolytics is "significantly under-recognized and undervalued, and presents an attractive investment opportunity." The company's lead program Pelareorep is a RNA reovirus oncolytic virus that has been safely dosed in greater than 1,100 patients across a variety of cancers, Li points out.
BMY Bristol-Myers
$52.44

-0.15 (-0.29%)

12/11/18
GABE
12/11/18
NO CHANGE
GABE
Buy
Gabelli sees Clovis as likely takeout target, top biotech pick in 2019
Gabelli analyst Jing He highlights Clovis (CLVS) as his top biotech pick in 2019. With the Tesaro (TSRO) acquisition by GlaxoSmithKline (GSK), Clovis will become the only standalone PARP, which the analyst believes makes it the most likely takeout target in 2019. He continues to believe Bristol-Myers (BMY), Sanofi (SNY) and Roche (RHHBY) to be the most interested buyers. The analyst reiterates a Buy rating on Clovis' shares.
12/06/18
12/06/18
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Activision Blizzard (ATVI) upgraded to Overweight from Neutral at JPMorgan with analyst Alexia Quadrani saying the stock is down 45% from an all-time high in early October, and now trades at 16.5 times forward consensus earnings, compared to 25.5 times and 23.0 times on average over the prior one and three year periods. 2. Bristol-Myers (BMY) upgraded to Outperform from Market Perform at BMO Capital with analyst Alex Arfaei saying the risk-reward on the stock at current price "seems attractive." 3. Hostess Brands (TWNK) upgraded to Overweight from Neutral at JPMorgan analyst Ken Goldman saying by this time next year, today's two major headwinds - lost business with Walmart (WMT) and the "EBITDA-hemorrhaging" Cloverhill acquisition - will be lapped and potentially become tailwinds. 4. Spirit Airlines (SAVE) upgraded to Outperform from Neutral at with analyst Jose Caiado De Sousa saying after a "massive" Q4 unit revenue guidance boost last week, the analyst sees further upside in the equity into H1 of 2019, with expected continued momentum in non-ticket revenue production amid a lower oil environment and a benign competitive backdrop. 5. Synopsys (SNPS) upgraded to Buy from Hold at Benchmark with analyst Gary Mobley citing slightly better than expected Q4 results and in-line FY19 guidance. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
12/06/18
JPMS
12/06/18
NO CHANGE
Target $70
JPMS
Overweight
JPMorgan still sees path to substantial Opdivo growth despite Bristol's setbacks
JPMorgan analyst Chris Schott said that investors are clearly concerned about Opdivo growth following several recent setbacks for Bristol-Myers, including mixed TMB data, pending RCC competition, and a failed SCLC study, but he still sees a path to substantial growth for the drug based on the numerous important readouts in both lung and non-lung indications coming in the next 12 months. Meanwhile, his analysis suggests Bristol-Myers' share price reflects little, if any, Opdivo growth from current levels. Given his view, and its convergence with what he believes to be the consensus view, on Opdivo, Schott sees the long term risk/reward for Bristol shares as highly attractive and keeps an Overweight rating on the stock with a $70 price target.
12/06/18
BMOC
12/06/18
UPGRADE
Target $60
BMOC
Outperform
Bristol-Myers upgraded to Outperform at BMO Capital on better Opdivo sales
As reported earlier, BMO Capital analyst Alex Arfaei upgraded Bristol-Myers to Outperform from Market Perform and raised his price target to $60 from $56, saying the risk-reward on the stock at current price "seems attractive". The analyst notes that a number of R&D setbacks have reduced expectations for the company's immuno-oncology franchise, raising his forecasts on Opdivo to reflect the "low" street consensus. Arfaei adds that the Street is modeling flattish gross margins, but his forecast calls for a 2% improvement by 2021 with Opdivo revenue expectations coming about 10%-15% above consensus. The analyst also raises his FY19 EPS view to $4.18 from $3.93 to reflect the more optimistic Opdivo targets.

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K

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TTWO

Take-Two

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IGMS

IGM Biosciences

$17.53

-0.125 (-0.71%)

19:42
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LMAT

LeMaitre

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WE

We Company

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SoftBank

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SoftBank seeking control of WeWork through financing package, WSJ says »

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We Company

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KOD

Kodiak Sciences

$18.24

1.34 (7.93%)

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ADVM

Adverum Biotechnologies

$5.29

0.11 (2.12%)

18:29
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18:29
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ADVM

Adverum Biotechnologies

$5.29

0.11 (2.12%)

18:23
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COP

ConocoPhillips

$56.41

0.55 (0.98%)

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T

AT&T

$37.58

0.17 (0.45%)

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Comcast

$45.53

1.02 (2.29%)

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T

AT&T

$37.58

0.17 (0.45%)

CMCSA

Comcast

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1.02 (2.29%)

CMCSK

Comcast

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(0.00%)

SNE

Sony

$58.16

0.83 (1.45%)

LGF.A

Lionsgate

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0.22 (2.37%)

LGF.B

Lionsgate

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0.19 (2.16%)

DIS

Disney

$130.08

0.73 (0.56%)

VIAB

Viacom

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0.505 (2.24%)

VIA

Viacom

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PCG

PG&E

$8.08

0.3 (3.86%)

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TTGT

TechTarget

$22.64

0.14 (0.62%)

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Sonic Healthcare

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TTGT

TechTarget

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SKHCY

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NTAP

NetApp

$51.50

1.74 (3.50%)

HPE

HP Enterprise

$14.35

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HLF

Herbalife Nutrition

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FORR

Forrester

$32.43

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CSCO

Cisco

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CVLT

Commvault

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FB

Facebook

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KBH

KB Home

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BX

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GOOG

Alphabet

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Alphabet

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SPX

S&P 500

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SPDR S&P 500 ETF Trust

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AGN

Allergan

$169.06

1.255 (0.75%)

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LYFT

Lyft

$39.49

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Uber

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1.19 (4.12%)

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LYFT

Lyft

$39.49

1.8 (4.78%)

UBER

Uber

$30.09

1.19 (4.12%)

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GM

General Motors

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0.9 (2.60%)

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MRK

Merck

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0.6 (0.72%)

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Johnson & Johnson

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2.32 (1.80%)

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Congo to start using Johnson & Johnson Ebola vaccine next month, Reuters says »

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Merck

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JNJ

Johnson & Johnson

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2.32 (1.80%)

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HMTV

Hemisphere Media

$11.70

0.05 (0.43%)

15:48
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Hemisphere Media initiated at Wells Fargo »

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PFE

Pfizer

$36.11

0.31 (0.87%)

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CNCE

Concert Pharmaceuticals

$5.85

(0.00%)

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INCY

Incyte

$76.14

0.38 (0.50%)

15:23
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LLY

Eli Lilly

$108.37

1.54 (1.44%)

14:15
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14:15
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Eli Lilly says Taltz met co-primary endpoints in Phase 3 plaque psoriasis study »

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