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ONCS

OncoSec

$0.82

-0.0489 (-5.62%)

08:05
12/12/18
12/12
08:05
12/12/18
08:05

OncoSec reports updated tumor responses in study of melanoma combinaton

OncoSec (ONCS) announced an update regarding tumor responses in its Keynote-695 global, multicenter Phase 2b, open-label trial of intratumoral delivery of Tavo with intravenous Keytruda in patients with unresectable, advanced melanoma. The company previously reported that, of the first nine patients to reach initial tumor evaluation, two patients had a partial response. Both responses have been confirmed by blinded independent review. Further, in both cases, response duration has now reached six months. One of these previously assessed partial responses has now become a complete response per investigator assessment at the six-month tumor evaluation timepoint. Enrollment is ongoing and the company expects to complete the study next year. Tavo was well-tolerated, with primarily Grade 1 adverse advents associated with injection site or procedural pain. One Tavo related Grade 3 SAE of cellulitis was reported and resolved. Keynote-695 is expected to be completed in 2019. Based on the outcome of the study, the company plans to file for accelerated approval by end of 2019 or early 2020. Tavo has received both Orphan Drug and Fast-Track Designation by the FDA.

ONCS OncoSec
$0.82

-0.0489 (-5.62%)

11/07/18
HCWC
11/07/18
DOWNGRADE
Target $1
HCWC
Neutral
OncoSec downgraded to Neutral from Buy at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju downgraded OncoSec to Neutral from Buy after the company reported preliminary top-line data from the PISCES/KEYNOTE-695 trial of TAVO with Keytruda in metastatic melanoma patients who have failed anti-PD-1 therapy, stating that his first impression is that the early efficacy results are "underwhelming." He noted that other second generation I/O agents have demonstrated higher response rates and while TAVO may eventually obtain regulatory approval, its efficacy may not be differentiated enough for wide market adoption. Selvaraju lowered his price target on OncoSec shares to $1 from $4.
11/06/18
PIPR
11/06/18
NO CHANGE
Target $3
PIPR
Overweight
OncoSec price target lowered to $3 from $5 at Piper Jaffray
After OncoSec (ONCS) reported preliminary Phase 2b KEYNOTE-695 data for Tavo combined with Merck's (MRK) Keytruda in PD-1 refractory melanoma patients, Piper Jaffray analyst Edward Tenthoff said the data, while early, show evidence of clinical activity, adding that he believes duration of response data will be important. However, OncoSec shares are down 52% today, which Tenthoff attributes to the lower response rate compared to prior data in different patients. The analyst keeps an Overweight rating on OncoSec shares, but lowered his price target on the stock to $3 from $5 as he pushed out his approval projections for Tavo by one year in the U.S. and Europe.
10/15/18
PIPR
10/15/18
NO CHANGE
Target $5
PIPR
Overweight
Piper reiterates Overweight on OncoSec with $5 price target
Piper Jaffray analyst Edward Tenthoff reiterates an Overweight rating on OncoSec Medical with a $5 price target after the company announced it initiated a Phase II study of tavokinogene telseplasmid plus Keytruda in and triple negative breast cancer patients who have received one prior chemo or immunotherapy with preliminary data in 2019. The primary driver for OncoSec shares remains the Stage 1 Phase IIb Pisces data on tavokinogene telseplasmid plus Keytruda in PD-1 refractory melanoma in November, Tenthoff tells investors in a research note. He points out that depending on the data, OncoSec may initiate Stage 2 of the study, which could serve as the basis for accelerated approval in melanoma in 2020.
08/14/18
PIPR
08/14/18
NO CHANGE
Target $5
PIPR
Overweight
OncoSec price target raised to $5 from $4 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff raised his price target for OncoSec Medical to $5 saying tavokinogene telseplasmid has demonstrated proof-of-concept data in relapsed/refractory melanoma. The analyst expects final Phase II OMS-100 monotherapy plus preliminary Phase IIb data at the Society for Immunotherapy of Cancer meeting in November. Depending upon the strength of data in Stage 2 of this trial, OncoSec may be able to seek accelerated approval in melanoma in 2020, Tenthoff tells investors in a research note after taking over coverage of the name. He maintains Piper's Overweight rating on OncoSec.

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BA

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2.3 (1.40%)

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COP

ConocoPhillips

$53.99

-0.55 (-1.01%)

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AMZN

Amazon.com

$1,757.77

-30.07 (-1.68%)

, NFLX

Netflix

$275.40

-17.88 (-6.10%)

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Amazon.com

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NFLX

Netflix

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CMCSK

Comcast

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CMCSA

Comcast

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T

AT&T

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DIS

Disney

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AKS

AK Steel

$2.45

0.055 (2.30%)

, MT

ArcelorMittal

$14.58

0.03 (0.21%)

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$2.45

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MT

ArcelorMittal

$14.58

0.03 (0.21%)

NUE

Nucor

$51.69

-0.11 (-0.21%)

STLD

Steel Dynamics

$28.71

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TMST

TimkenSteel

$5.42

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X

U.S. Steel

$10.72

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GM

General Motors

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-0.01 (-0.03%)

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AAVMY

ABN Amro

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Banco Bilbao

$5.38

0.07 (1.32%)

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BCS

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BLK

BlackRock

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BNP Paribas

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C

Citi

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0.16 (0.23%)

CAIXY

CaixaBank

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CIB

Bancolombia

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CS

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EV

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GS

Goldman Sachs

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HSBC

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JPM

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MA

MasterCard

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MCO

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MS

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NYT

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RBS

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RY

Royal Bank of Canada

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SMFG

Sumitomo Mitsui

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State Street

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3.69 (6.18%)

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V

Visa

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ZURVY

Zurich Insurance

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STT

State Street

$63.40

3.69 (6.18%)

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SUN

Sunoco

$32.43

0.32 (1.00%)

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TLF

Tandy Leather

$4.61

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Tandy Leather

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AAPL

Apple

$236.29

0.99 (0.42%)

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JPM

JPMorgan

$120.60

0.21 (0.17%)

, FB

Facebook

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JPMorgan

$120.60

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FB

Facebook

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PYPL

PayPal

$101.25

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MA

MasterCard

$270.90

-5.74 (-2.07%)

V

Visa

$175.83

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EBAY

eBay

$38.82

-0.31 (-0.79%)

BKNG

Booking Holdings

$2,012.20

-16.43 (-0.81%)

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GLD

SPDR Gold Shares

$140.47

-0.13 (-0.09%)

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TECK

Teck Resources

$16.48

0.11 (0.67%)

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OSK

Oshkosh

$77.22

0.46 (0.60%)

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OVLY

Oak Valley Bancorp

$16.40

-0.16 (-0.97%)

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FTNW

FTE Networks

$0.79

-0.0185 (-2.29%)

17:21
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TNXP

Tonix Pharmaceuticals

$0.45

0.0048 (1.07%)

17:12
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RLMD

Relmada Therapeutics

$20.18

1.07 (5.60%)

17:10
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Syndicate
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16:55
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General news
Breaking General news story  »

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NWSA

News Corp.

$13.48

-0.19 (-1.39%)

, NWS

News Corp

$13.79

-0.11 (-0.79%)

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News Corp.

$13.48

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NWS

News Corp

$13.79

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FB

Facebook

$185.96

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NYT

New York Times

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0.21 (0.71%)

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WAIR

Wesco Aircraft

$11.01

0.01 (0.09%)

16:46
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Conference/Events
Wesco Aircraft to host special shareholder meeting »

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FOMX

Foamix

$3.15

-0.09 (-2.78%)

16:41
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16:41
Hot Stocks
Breaking Hot Stocks news story on Foamix »

Foamix up 7.5% at $3.35…

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