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AVRO

Avrobio

$21.28

-0.45 (-2.07%)

07:09
12/19/18
12/19
07:09
12/19/18
07:09

Avrobio receives orphan designation from FDA for RD-01

Avrobio announced that the FDA has granted orphan-drug designation for the company's investigational gene therapy, AVR-RD-01, for the treatment of Fabry disease. The gene therapy consists of the patient's own hematopoietic stem cells transduced with Avrobio's lentiviral vector, carrying a functional version of the GLA gene that encodes a-galactosidase, the enzyme that is deficient in Fabry disease. Patients with Fabry disease are currently enrolling in AVRO-RD-01-201, the company's Phase 2 clinical trial, as well as in an investigator-sponsored Phase 1 study.

AVRO Avrobio
$21.28

-0.45 (-2.07%)

11/27/18
LEER
11/27/18
INITIATION
LEER
Leerink initiates select Genetic Medicine names on increasing regulatory clarity
Leerink analyst Mani Foroohar initiated select Genetic Medicine stocks, stating that the field is "is rich with companies developing drugs" to treat rare diseases and that he is increasingly more bullish on "innovation velocity and increasing regulatory clarity in the sector. Based on his "balanced view of pricing dynamics", the analyst issues an Outperform rating on Wave Life Sciences (WVE), Rocket Pharmaceuticals (RCKT), Intellia Therapeutics (NTLA), Eidos Therapeutics (EIDX), Dicerna (DRNA) and Bluebird Bio (BLUE). The analyst likes Wave Life Sciences as a pure play on Oligotherapeutics and its stereopure chemistry platform as a differentiated approach to oligo drug design. Foroohar is positive on Rocket Pharma's lead assets in gene therapies for Fanconi Anemia and Leukocyte Adhesion Deficiency-I "which will likely be the company's first potential approved product." The analyst is positive on Intellia Therapeutics' "robust balance sheet to support development, trading at a material discount to closest comps peers". For Eidos, the analyst cites the prospects of its drug candidate for TTR amyloidosis currently in a placebo-controlled Phase 2 study that may offer a competitive profile relative to Pfizer's (PFE) tafamidis. For Dicerna, Foroohar notes that its DCR-PHXC "is an RNAi therapeutic that targets lactate dehydrogenase A for the treatment of all subtypes of Primary Hyperoxaluria vs. competitor Alnylam's (ALNY) lumasiran, which only treats PH Type 1. For Bluebird Bio, the analyst is positive on its position as a "leader in ex vivo gene therapy, with four programs with visibility towards near-term regulatory approval". Foroohar initiates Avrobio (AVRO), Alnylam (ALNY), and Ionis Pharmaceuticals (IONS) with Market Perform rating based on competitive launches for their products along with "mixed" early signs of their results. The analyst also rates Regenxbio (RGNX) at underperform, saying that its "current valuation more than accounts for robust royalty streams from sales in spinal muscular atrophy" and other partnered assets.
11/27/18
LEER
11/27/18
INITIATION
Target $27
LEER
Market Perform
Avrobio initiated with a Market Perform at Leerink
Leerink analyst Mani Foroohar initiated Avrobio with a Market Perform rating and a price target of $27.
10/09/18
GUGG
10/09/18
INITIATION
GUGG
Buy
Avrobio initiated with a Buy at Guggenheim
Guggenheim analyst Whitney Ijem initiated Avrobio with a Buy rating and $35 price target, calling the two-day 61% sell off on the company's Ph1 Fabry data update an overreaction.
09/17/18
HCWC
09/17/18
INITIATION
Target $47
HCWC
Buy
Avrobio initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Debjit Chattopadhyay started Avrobio with a Buy rating and $47 price target. The status quo in the treatment of lysosomal storage disorders is likely to be disrupted, Chattopadhyay tells investors in a research note. The analyst recommends being opportunistic on pullbacks and building a position in the name.

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NBEV

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GM

General Motors

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$NSD

NASDAQ Market Internals

$0.00

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$NYE

NYSE Market Internals

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PLAN

Anaplan

$44.40

-3.33 (-6.98%)

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MCK

McKesson

$146.86

8.69 (6.29%)

, ABC

AmerisourceBergen

$87.62

4.44 (5.34%)

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MCK

McKesson

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CAH

Cardinal Health

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JNJ

Johnson & Johnson

$136.44

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TEVA

Teva

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0.37 (5.32%)

GM

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UAL

United Airlines

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BA

Boeing

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BAC

Bank of America

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MGM

MGM Resorts

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BX

Blackstone

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ACHN

Achillion

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ALXN

Alexion

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SFIX

Stitch Fix

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WDAY

Workday

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WB

Weibo

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APHA

Aphria

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NOW

ServiceNow

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AVD

American Vanguard

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HOV

Hovnanian

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OMI

Owens & Minor

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FIT

Fitbit

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GM

General Motors

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PDCO

Patterson Companies

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HSIC

Henry Schein

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XLF

Financial Select Sector

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