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VRTX

Vertex

$162.86

-0.555 (-0.34%)

12:09
12/19/18
12/19
12:09
12/19/18
12:09

Vertex will submit CF treatment Orkambi and Symkevi combination in Scotland

Vertex Pharmaceuticals announced that, following constructive discussions with the Scottish Government, it will submit ORKAMBI, lumacaftor/ivacaftor, as well as SYMKEVI, tezacaftor/ivacaftor, to be used in combination with ivacaftor, to the Scottish Medicines Consortium, SMC, for appraisal. If accepted by the SMC for use on the NHS in Scotland, eligible patients with cystic fibrosis in Scotland could have access to these precision medicines in 2019. "Our recent conversations with the Scottish Government, and the SMC's orphan medicines process have provided important flexibility for evaluating precision medicines, such as cystic fibrosis transmembrane conductance regulator modulators. Their methods reflect the innovative nature of medicines that have the potential to extend life for patients with rare diseases, like CF," said Ludovic Fenaux, Senior Vice President, Vertex International. "We are hopeful that, through this process, all eligible patients in Scotland could have access to our medicines soon." While the SMC reviews the submissions, clinicians could apply for access to lumacaftor/ivacaftor as well as tezacaftor/ivacaftor in combination with ivacaftor for individual patients based on clinical need via the Peer Approved Clinical SystemTier 2 process for 'individual access to medicines not yet generally available on the NHS'. Vertex and the Scottish Government have also agreed to a confidential discount which will be applied to applications to the PACS Tier 2 process.

  • 11

    Feb

VRTX Vertex
$162.86

-0.555 (-0.34%)

12/17/18
GUGG
12/17/18
INITIATION
GUGG
Neutral
Vertex resumed with a Neutral at Guggenheim
Guggenheim analyst Whitney Ijem resumed coverage of Vertex Pharmaceuticals with a Neutral rating. The analyst thinks a successful launch of the triple combo is priced into the shares and that the risk/reward on progress is "skewed to the downside at this stage." Further, she thinks any competitive cystic fibrosis updates could be an overhang and the "what's next" question will become more important.
12/17/18
SBSH
12/17/18
NO CHANGE
SBSH
Buy
Vertex CFO resignation 'no reason for concern,' says Citi
After Vertex disclosed that Thomas Graney notified the company on December 13 that he is resigning as CFO, Citi analyst Robyn Karnauskas said she sees "no reason for concern," noting that the company tells her that Graney resigned in order to pursue an opportunity at an emerging gene therapy company. The company, which also noted that interim CFO Ian Smith had previously held the CFO role, expects to initiate a CFO search shortly and will look both internally and externally, added Karnauskas, who keeps a Buy rating on the shares.
11/30/18
NEED
11/30/18
INITIATION
Target $62
NEED
Buy
Crispr Therapeutics initiated with a Buy at Needham
Needham analyst Alan Carr initiated CRISPR Therapeutics (CRSP) with a Buy rating and a price target of $62 based on its position as a "leader in gene editing". The analyst notes that the company is "initially focused on ex vivo applications of the technology associated with reduced technical and safety risks", which he believes to hold "substantial value, particularly in immuno-oncology." Carr adds that with Crispr and collaborator Vertex (VRTX) recently launching a clinical development of CTX-001 in Beta Thalassemia and Sickle Cell Disease, he estimates the company to launch these products in the U.S. in 2022 and 2023, respectively.
11/27/18
PIPR
11/27/18
NO CHANGE
Target $217
PIPR
Overweight
Piper says Vertex's VX-659 achieved 'unprecedented' improvement in trials
After Vertex announced 4-week efficacy and 12-week safety data from two TripleRx Phase 3 trials of VX-659 plus Symdeko, Piper Jaffray analyst Edward Tenthoff said VX-659 achieved "unprecedented" four-week mean absolute improvement in ppFEV1 in both patient populations studied. He anticipates Vertex will file an NDA on the best TripleRx regimen in mid 2019 and currently sees the first TripleRx reaching the market in 2020. Tenthoff keeps an Overweight rating and $217 price target on Vertex shares.

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SPY

SPDR S&P 500 ETF Trust

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S&P 500

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Bank of America

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Bank of America

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ABT

Abbott

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USB

U.S. Bancorp

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PNC

PNC Financial

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BK

BNY Mellon

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0.47 (1.07%)

ALLY

Ally Financial

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CMA

Comerica

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FHN

First Horizon

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RIO

Rio Tinto

$51.40

-0.43 (-0.83%)

20:17
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Rio Tinto reports Q3 Pilbara iron ore output 87.3M tons, up 6% from last year »

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GNTX

Gentex

$26.98

0.65 (2.47%)

20:16
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Gentex initiated at Guggenheim »

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VNE

Veoneer

$16.11

0.82 (5.36%)

20:16
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VC

Visteon

$82.45

0.63 (0.77%)

20:15
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Initiation
Visteon initiated at Guggenheim »

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DLPH

Delphi Technologies

$14.37

0.45 (3.23%)

20:14
10/15/19
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Initiation
Delphi Technologies initiated at Guggenheim »

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BWA

BorgWarner

$37.74

0.68 (1.83%)

20:13
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BorgWarner initiated at Guggenheim »

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LEA

Lear

$121.75

3.94 (3.34%)

20:13
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Initiation
Lear initiated at Guggenheim »

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DFIN

Donnelley Financial Solutions

$10.54

0.035 (0.33%)

20:12
10/15/19
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20:12
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Initiation
Donnelley Financial Solutions initiated at B. Riley FBR »

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JNJ

Johnson & Johnson

$132.84

2.17 (1.66%)

, TEVA

Teva

$6.96

0.22 (3.26%)

19:17
10/15/19
10/15
19:17
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Periodicals
As part of proposed settlement, Teva offers $15B of free drugs, Bloomberg says »

The report also notes…

JNJ

Johnson & Johnson

$132.84

2.17 (1.66%)

TEVA

Teva

$6.96

0.22 (3.26%)

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WAFD

Washington Federal

$36.81

0.15 (0.41%)

19:04
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Earnings
Washington Federal reports Q4 EPS 66c, consensus 65c »

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INGR

Ingredion

$81.17

0.94 (1.17%)

19:01
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Hot Stocks
Ingredion discloses malware affecting certain data centers »

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  • 31

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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$298.89

2.88 (0.97%)

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S&P 500

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SPDR S&P 500 ETF Trust

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PBR

Petrobras

$14.40

0.02 (0.14%)

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Petrobras signs charter contracts for two FPSO platforms »

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  • 25

    Oct

SNBR

Sleep Number

$46.69

0.48 (1.04%)

, UAL

United Airlines

$87.90

0.9 (1.03%)

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Fly Intel: After Hours Movers »

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Sleep Number

$46.69

0.48 (1.04%)

UAL

United Airlines

$87.90

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MCK

McKesson

$138.17

4.01 (2.99%)

ABC

AmerisourceBergen

$83.18

1.6 (1.96%)

CAH

Cardinal Health

$47.93

1.16 (2.48%)

FULT

Fulton Financial

$15.90

0.19 (1.21%)

ETN

Eaton

$82.16

1.29 (1.60%)

SFIX

Stitch Fix

$20.83

-0.38 (-1.79%)

MGM

MGM Resorts

$27.87

-0.1 (-0.36%)

JBHT

J.B. Hunt

$111.65

1.985 (1.81%)

IBKR

Interactive Brokers

$47.43

0.26 (0.55%)

RYTM

Rhythm Pharmaceuticals

$20.90

0.52 (2.55%)

PRQR

ProQR Therapeutics

$6.21

-0.09 (-1.43%)

NTRA

Natera

$39.21

1.01 (2.64%)

PRNB

Principia Biopharma

$29.88

0.7 (2.40%)

X

U.S. Steel

$11.43

0.27 (2.42%)

ARCE

Arco Platform

$48.15

0.75 (1.58%)

TW

Tradeweb Markets

$39.79

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KKR

KKR

$26.79

0.67 (2.57%)

, DB

Deutsche Bank

$7.79

0.235 (3.11%)

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KKR, partners cancel Latitude Financial IPO, Reuters reports »

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KKR

$26.79

0.67 (2.57%)

DB

Deutsche Bank

$7.79

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TW

Tradeweb Markets

$39.79

-0.14 (-0.35%)

18:20
10/15/19
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Hot Stocks
Breaking Hot Stocks news story on Tradeweb Markets »

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TW

Tradeweb Markets

$39.79

-0.14 (-0.35%)

18:17
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10/15/19
18:17
Syndicate
Tradeweb Markets files to sell 14.8M shares of Class A common stock »

Refinitiv will continue…

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TW

Tradeweb Markets

$39.79

-0.14 (-0.35%)

18:16
10/15/19
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10/15/19
18:16
Earnings
Tradeweb Markets sees Q3 adjusted EPS 27c, consensus 25c »

Sees Q3 revenue $200.98M,…

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  • 07

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EDIT

Editas Medicine

$20.30

0.48 (2.42%)

18:15
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Hot Stocks
Editas Medicine, AskBio enter research collaboration over in vivo delivery »

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WYNN

Wynn Resorts

$114.78

2.43 (2.16%)

18:03
10/15/19
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18:03
Periodicals
NV regulators want to ban Steve Wynn from NV casino industry, Reuters says »

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