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VRTX

Vertex

$164.04

-1.16 (-0.70%)

08:04
01/03/19
01/03
08:04
01/03/19
08:04

Vertex, Arbor Biotechnologies enter collaboration for novel proteins

Vertex Pharmaceuticals and Arbor Biotechnologies announced that the two companies have entered into a strategic research collaboration focused on the discovery of novel proteins including DNA endonucleases to advance the development of new gene-editing therapies for cystic fibrosis and four other diseases to be selected later. Arbor has developed a protein biodiscovery platform that includes a comprehensive set of technologies and techniques, integrating machine learning, genome sequencing, gene synthesis, and high-throughput screening that will augment Vertex's efforts to develop gene-editing approaches for the treatment of serious diseases. Under the terms of the collaboration, scientists from Vertex and Arbor will work closely together to discover novel proteins and tools that Vertex may use in the development of new medicines. The focus of the collaboration is to discover novel programmable DNA endonucleases or nickases with high fidelity and catalytic activity as well as novel transduction approaches. Discovery activities will be conducted primarily by Arbor and funded by Vertex. Vertex will provide Arbor with an up-front cash commitment, fund research activities, and will pay research, development, regulatory, and commercial milestones, as well as royalties on future net sales. Vertex will also make an investment in Arbor in the form of a convertible note and obtain an observer seat on the Arbor Board of Directors.

  • 11

    Feb

VRTX Vertex
$164.04

-1.16 (-0.70%)

01/02/19
01/02/19
DOWNGRADE

Market Perform
Vertex downgraded to Market Perform on lack of catalysts at Raymond James
As previously reported, Raymond James downgraded Vertex to Market Perform from Outperform. Analyst Laura Chico said Vertex lacks near-term catalysts which makes it more vulnerable in a "risk off" environment and said success is largely priced in at this point.
01/02/19
RAJA
01/02/19
DOWNGRADE
RAJA
Market Perform
Vertex downgraded to Market Perform from Outperform at Raymond James
12/17/18
GUGG
12/17/18
INITIATION
GUGG
Neutral
Vertex resumed with a Neutral at Guggenheim
Guggenheim analyst Whitney Ijem resumed coverage of Vertex Pharmaceuticals with a Neutral rating. The analyst thinks a successful launch of the triple combo is priced into the shares and that the risk/reward on progress is "skewed to the downside at this stage." Further, she thinks any competitive cystic fibrosis updates could be an overhang and the "what's next" question will become more important.
12/17/18
SBSH
12/17/18
NO CHANGE
SBSH
Buy
Vertex CFO resignation 'no reason for concern,' says Citi
After Vertex disclosed that Thomas Graney notified the company on December 13 that he is resigning as CFO, Citi analyst Robyn Karnauskas said she sees "no reason for concern," noting that the company tells her that Graney resigned in order to pursue an opportunity at an emerging gene therapy company. The company, which also noted that interim CFO Ian Smith had previously held the CFO role, expects to initiate a CFO search shortly and will look both internally and externally, added Karnauskas, who keeps a Buy rating on the shares.

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CPE

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CHWY

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PFG

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VAL

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KSS

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