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SYRS

Syros Pharmaceuticals

$6.23

0.47 (8.16%)

17:41
01/06/19
01/06
17:41
01/06/19
17:41

Syros announces strategic priorities, milestones ahead of JPMorgan conference

Syros Pharmaceuticals outlined its strategic priorities and expected upcoming milestones. The Company will review these priorities in a presentation at the 37th Annual JPMorgan Healthcare Conference on Thursday, January 10, 2019. The company expects to complete enrollment in mid-2019 in the ongoing Phase 2 study cohort evaluating the safety and efficacy of SY-1425 in combination with azacitidine in RARA and IRF8 biomarker-positive patients with newly diagnosed acute myeloid leukemia who are not suitable candidates for standard chemotherapy. Syros also expects to report updated clinical data in the second half of 2019 on SY-1425 in combination with azacitidine, and report initial clinical data in the fourth quarter of 2019 from the expansion portion of the ongoing Phase 1 trial, which is assessing SY-1365 as a single agent and in combination with standard-of-care therapies in multiple ovarian and breast cancer patient populations. Additionally, the company expects to complete IND-enabling studies to support initiation of a Phase 1 oncology trial in early 2020. Syros also announced that it has made a portfolio prioritization decision not to pursue further development of SY-1425 in combination with daratumumab beyond completion of the ongoing pilot cohort in the Phase 2 trial. Based on its current operating plans, Syros expects that its existing cash, cash equivalents and marketable securities will enable it to fund its anticipated operating expenses and capital expenditure requirements into 2020. Syros had approximately $113.2M in cash, cash equivalents and marketable securities as of September 30, 2018.

  • 07

    Jan

SYRS Syros Pharmaceuticals
$6.23

0.47 (8.16%)

07/17/18
PIPR
07/17/18
NO CHANGE
Target $28
PIPR
Overweight
Piper reiterates Overweight on Syros after call with oncologists
After hosting a call with two hematologic oncologists to highlight the unmet need to treat myelodysplastic syndromes and acute myeloid leukemia, Piper Jaffray analyst Edward Tenthoff reiterates an Overweight rating on shares of Syros Pharmaceuticals with a $28 price target. The analyst notes the company is conducting a Phase II study for SY-1425 in combination with azacitidine or anti-CD38 antibody Darzalex to treat intermediate to high-risk MDS or AML patients with data likely in Q4. Tenthoff remains confident in Syros' combination strategies in the ongoing study.
11/05/18
ROTH
11/05/18
UPGRADE
ROTH
Buy
Syros Pharmaceuticals upgraded to Buy from Neutral at Roth Capital
11/16/18
PIPR
11/16/18
NO CHANGE
Target $28
PIPR
Overweight
Syros Phase I dose escalation data 'encouraging,' says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff found the Phase I dose escalation data presented by Syros Pharmaceuticals for its CDK7 inhibitor SY-1365 "encouraging." Intravenous SY-1365 was safe and well tolerated with manageable adverse events, Tenthoff tells investors in a research note. The analyst points out that one relapsed ovarian cancer patient achieved partial response with six additional patients with stable disease, bringing the disease control rate to 37% in seven of 19 evaluable patients. He reiterates an Overweight rating on Syros with a $28 price target.

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