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PTGX

Protagonist Therapeutics

$7.14

0.03 (0.42%)

07:04
01/09/19
01/09
07:04
01/09/19
07:04

Protagonist Therapeutics begins Phase 2 trial of beta thalassemia candidate

Protagonist Therapeutics has dosed the first patient in the Phase 2 study of PTG-300, an injectable hepcidin mimetic peptide in development for the treatment of patients with beta thalassemia, a rare disease characterized by chronic anemia and iron overload. The study is designed to evaluate the safety and preliminary efficacy of PTG-300 in patients with transfusion-dependent or non-transfusion-dependent beta thalassemia. In a completed Phase 1 study in healthy volunteers, administration of PTG-300 was well tolerated and demonstrated a dose-related and sustained reduction in serum iron levels.

PTGX Protagonist Therapeutics
$7.14

0.03 (0.42%)

12/06/18
12/06/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. LG Display (LPL) initiated with a Buy at Citi. 2. Twitter (TWTR) and Alphabet (GOOG, GOOGL) were initiated with a Buy at Guggenheim, while Snap (SNAP) and Facebook (FB) were initiated with a Neutral. 3. Apache (APA) initiated with an Overweight at Stephens. 4. CorMedix (CRMD) initiated with a Buy at Roth Capital. 5. Protagonist Therapeutics (PTGX) initiated with a Buy at Nomura Instinet. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
12/06/18
NOMU
12/06/18
INITIATION
Target $13
NOMU
Buy
Protagonist Therapeutics initiated with a Buy at Nomura Instinet
Nomura Instinet analyst Christopher Marai started Protagonist Therapeutics with a Buy rating and $13 price target. The analyst believes Protagonist is trading at a "steep discount," having sold off 69% year-to-date following an "erroneous" Phase 2 trial futility assessment for PTG-100, an oral alpha4beta7 integrin antagonist peptide.
08/06/18
LEER
08/06/18
NO CHANGE
Target $21
LEER
Outperform
Protagonist Therapeutics' PTG-100 'back on track,' says Leerink
Leerink analyst Joseph Schwartz says PTG-100 in Ulcerative colitis is "back on track," increasing his confidence in Protagonist Therapeutics' peptide technology platform. The analyst notes that the company reported this morning an unexpected, but very positive, turnaround of its lead program, PTG-100, and will now pursue late-stage clinical development, assuming a positive discussion with the FDA occurs in 2H. While it is unfortunate that the program lost some time when the data set was initially mis-scored and deemed futile when in fact today's news suggests that PTG-100 could have robust clinical efficacy, Schwartz believes that Protagonist's persistence to uncover the truth leading to the resuscitation of the program is positive. The analyst reiterates an Outperform rating on the stock and raised his price target on the shares to $21 from $13.
08/06/18
LEER
08/06/18
NO CHANGE
Target $21
LEER
Outperform
Protagonist price target raised to $21 after study re-analysis at Leerink
Leerink analyst Joseph P. Schwartz raised his price target on Protagonist Therapeutics shares to $21 from $13 after the company announced results from an independent blinded re-analysis of the Phase 2 PROPEL study of oral alpha-4-beta-7 integrin antagonist PTG-100 for the treatment of patients with ulcerative colitis. He maintains an Outperform rating on Protagonist shares.

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