Verona receives WHO approval for ensifentrine as recommended INN for RPL554
Verona Pharma announced that the World Health Organization, or WHO, approved "ensifentrine" as the recommended International Non-proprietary Name for the company's drug candidate, RPL554. In Phase 2 clinical trials completed to date, ensifentrine has been observed to result in bronchodilator effects when used alone or as an add-on treatment to other COPD bronchodilators, and has also shown anti-inflammatory effects in a standard challenge study with COPD-like inflammation in human subjects. Verona Pharma is currently conducting two further Phase 2 clinical trials: one to evaluate a nebulized formulation of ensifentrine as an add-on treatment to dual LAMA/LABA therapy and triple LAMA/LABA/ICS therapy, and the other to evaluate a dry powder inhaler formulation of ensifentrine for the maintenance treatment of COPD. The company also plans to evaluate ensifentrine in a metered-dose inhaler formulation as part of a comprehensive clinical program intended to fully demonstrate the clinical utility of ensifentrine in improving the standard of care for COPD. These data will be used to support the planning of the ensifentrine Phase 3 COPD program.