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NK

NantKwest

$1.36

0.01 (0.74%)

, MKGAY

Merck KGaA

$0.00

(0.00%)

08:08
01/09/19
01/09
08:08
01/09/19
08:08

NantKwest announces launch of MCC Phase II trial

NantKwest (NK) announced the launch of a novel triple combination, phase II clinical trial in Merkel cell carcinoma. NantKwest's phase II immunotherapy trial builds upon the company's earlier phase II single-combination study using its proprietary, off-the-shelf aNKTM natural killer cell therapy and IL-15/Fc superagonist, which produced an objective responses in 3 of 7 patients. In this new clinical trial, patients will be dosed with: (i) the novel chemotherapy-free combination of our haNK cell therapy, which are aNK cells that are genetically engineered to express the high-affinity variant of the CD16 receptor, (ii) avelumab, a PD-L1 targeting checkpoint inhibitor, and (iii) N-803, a superagonist IL-15/Fc cytokine therapy, in a regimen designed to synergistically optimize the therapeutic potential of each agent. In preclinical and human clinical studies conducted by NantKwest, the combination of haNK cells with a number of different therapeutic antibodies, including avelumab, led to enhanced tumor cell killing when compared to the use of the antibody alone. The IL-15/Fc superagonist N-803, developed by NantCell, Inc., an affiliate company, has been shown to synergistically activate NK and T cells and enhance cancer cell killing in both single agent and combination therapy. The PD-L1 checkpoint inhibitor avelumab, a monoclonal antibody developed by Merck KGaA (MKGAY) and approved in 2017 by the FDA, targets the programmed death-ligand 1 protein, commonly expressed on a wide range of cancer cells. Avelumab works by blocking PD-L1 from binding PD-1 receptors on T-cells, resulting in an increase in CD8+ T-cell immune responses. This effect is amplified with the addition of N-803 and haNK cells.

NK

NantKwest

$1.36

0.01 (0.74%)

MKGAY

Merck KGaA

$0.00

(0.00%)

NK NantKwest
$1.36

0.01 (0.74%)

08/09/18
SBSH
08/09/18
UPGRADE
Target $3
SBSH
Neutral
NantKwest upgraded to Neutral from Sell at Citi
Citi upgraded NantKwest to Neutral with an unchanged price target of $3.
10/16/18
SBSH
10/16/18
DOWNGRADE
SBSH
Sell
NantKwest downgraded to Sell from Neutral at Citi
10/17/18
SBSH
10/17/18
DOWNGRADE
Target $3
SBSH
Sell
Citi downgrades NantKwest to Sell on 'unwarranted' recent rally
Citi analyst Joel Beatty last night downgraded NantKwest to Sell from Neutral with an unchanged price target of $3. The analyst views the recent rally in the shares as "unwarranted" since he's not aware of any change in fundamentals. Beatty points out that NantKwest has a history of missing its own timelines for vaccine studies.
11/30/18
SBSH
11/30/18
UPGRADE
Target $2
SBSH
Neutral
NantKwest upgraded to Neutral from Sell at Citi
Citi analyst Joel Beatty upgraded NantKwest to Neutral while lowering his price target for the shares to $2 from $3. The analyst cites valuation for the upgrade following the recent pullback in the shares.
MKGAY Merck KGaA
$0.00

(0.00%)

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OCUL

Ocular Therapeutix

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0.61 (16.90%)

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EA

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VLKAY

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AMRN

Amarin

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MDT

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$NSD

NASDAQ Market Internals

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$NYE

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TOT

Total

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0.74 (1.32%)

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CZR

Caesars

$9.01

-0.41 (-4.35%)

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TSLA

Tesla

$294.87

3.69 (1.27%)

, MS

Morgan Stanley

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MS

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BDRBF

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ZG

Zillow

$40.94

5.87 (16.74%)

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Zillow

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ZG

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BECN

Beacon Roofing

$37.50

0.13 (0.35%)

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C

Citi

$64.03

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ZG

Zillow

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5.47 (15.60%)

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ZG

Zillow

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5.91 (16.87%)

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PFE

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0.88 (2.09%)

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PLNT

Planet Fitness

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FDX

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, AMZN

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FDX

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AMZN

Amazon.com

$1,625.63

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STMP

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UPS

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TROX

Tronox

$11.80

0.45 (3.96%)

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C

Citi

$64.24

-0.07 (-0.11%)

, INTC

Intel

$52.73

1.33 (2.59%)

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Citi, Intel upgrades, Roku, Nordstrom downgrades among today's top analyst calls »

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C

Citi

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-0.07 (-0.11%)

INTC

Intel

$52.73

1.33 (2.59%)

ROKU

Roku

$59.51

8.04 (15.62%)

JWN

Nordstrom

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KHC

Kraft Heinz

$34.95

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