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CRVS

Corvus Pharmaceuticals

$4.31

-0.47 (-9.83%)

08:36
01/10/19
01/10
08:36
01/10/19
08:36

Corvus Pharmaceuticals announces preclinical data from CPI-818 study

Corvus Pharmaceuticals announced data from a preclinical study of CPI-818, its investigational small molecule T-cell signaling pathway inhibitor. Study results indicated that orally-administered CPI-818 produced tumor regression in three of three companion dogs with spontaneous, naturally occurring T-cell lymphomas, without significant toxicity. These preclinical data are being presented in a poster at the T-cell Lymphoma Forum. Based on these data, Corvus plans to submit an investigational new drug, or IND, application with the FDA in early 2019. The company plans to evaluate CPI-818 in a Phase 1/1b study in patients with several types of T-cell lymphomas, including peripheral T-cell lymphoma, cutaneous T-cell lymphoma and others. Data demonstrated cytotoxicity against several types of human and mouse T-cell lymphomas at concentrations that do not harm normal T-cells. Also, data showed evidence of Th1 skewing in human and mouse lymphocytes, indicating that CPI-818 induced the differentiation of T-cells to cytotoxic T-cells, which is thought to be an important component of the immune system's destruction of cancer cells.

CRVS Corvus Pharmaceuticals
$4.31

-0.47 (-9.83%)

08/15/18
08/15/18
UPGRADE
Target $15

Outperform
Corvus Pharmaceuticals upgraded to Outperform at Credit Suisse
As previously reported, Credit Suisse analyst Michael Morabito upgraded Corvus Pharmaceuticals to Outperform from Neutral and raised the stock's price target to $15 from $11 after assuming coverage of the name. The analyst believes the company's lead product, CPI-444, has a clear lead in the clinic compared to competitors, and looks like a compelling treatment for PD-1 refractory patients, a growing market with PD-1 therapy being used increasingly in first-line settings.
08/15/18
FBCO
08/15/18
UPGRADE
FBCO
Outperform
Corvus Pharmaceuticals upgraded to Outperform from Neutral at Credit Suisse
06/05/18
JEFF
06/05/18
INITIATION
Target $17
JEFF
Buy
Corvus Pharmaceuticals initiated with a Buy at Jefferies
Jefferies analyst Biren Amin started Corvus Pharmaceuticals with a Buy rating and $17 price target. The analyst views CPI-444 as a potentially interesting immuno-oncology asset in non-small cell lung cancer and renal cell carcinoma.

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