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INCY

Incyte

$78.44

-0.22 (-0.28%)

07:34
01/22/19
01/22
07:34
01/22/19
07:34

Incyte treats first patient in Phase 3 clinical trial of itacitinib

Incyte Corporation announced that the first patient has been treated in GRAVITAS-309, a pivotal Phase 3 trial for the first-line treatment of patients with chronic graft-versus-host disease. The trial will evaluate the efficacy and safety of itacitinib, Incyte's novel and selective JAK1 inhibitor, in combination with corticosteroids compared to corticosteroids alone as a first-line treatment for moderate or severe chronic GVHD. GVHD is a condition that can occur after an allogeneic stem cell transplant, where the donated cells initiate an immune response and attack the transplant recipients organs, leading to significant morbidity and mortality. There are two forms of GVHD, acute and chronic, which can affect multiple organ systems including the skin, gastrointestinal tract and liver. It is estimated that there are approximately 15,000 new cases of GVHD diagnosed each year in the U.S., Europe and Japan, where approximately 12,000 new cases are acute GVHD and 3,000 de novo cases are chronic GVHD. The prevalence of chronic GVHD in the U.S., Europe and Japan is estimated to be approximately 25,000 patients. A Phase 3 study of itacitinib for the treatment of patients with acute GVHD is already underway, with results expected in 2019.

  • 24

    May

INCY Incyte
$78.44

-0.22 (-0.28%)

12/02/18
PIPR
12/02/18
NO CHANGE
Target $85
PIPR
Overweight
Initial Incyte PI3Kdelta combo data 'promising,' says Piper Jaffray
Piper Jaffray analyst Tyler Van Buren notes that Incyte presented an update of the Phase II trial evaluating INCB050465 in MF patients who have had suboptimal response to ruxolitinib monotherapy. While the initial data suggest clinical benefit in these patients, the addition of Cohorts 3 and 4 which incorporate continuous dosing of parsaclisib and will likely report in 2019, will be necessary to assess long-term benefit, he contends. Additionally, as many attempt to compare these data to the previously reported umbralisib combo data, the analyst views the differences in patient enrollment criteria between the parsaclisib and umbralisib combination programs as material, and therefore views any comparison as "futile." Van Buren has an Overweight rating and $85 price target on the shares.
01/03/19
GUGG
01/03/19
UPGRADE
GUGG
Buy
Incyte upgraded to Buy from Neutral at Guggenheim
01/15/19
GSCO
01/15/19
UPGRADE
Target $111
GSCO
Conviction Buy
Incyte upgraded to Conviction Buy from Buy at Goldman Sachs
Goldman Sachs analyst Salveen Richter added Incyte to his firm's Americas Conviction List and boosted his price target for the shares to $111 from $102. He keeps a Buy rating on the name. At current share levels, Incyte provides "pipeline and M&A optionality in the context of a solid commercial franchise," Richter tells investors in a research note. He points out the company's pipeline consists of 21 drugs across the verticals of oncology and inflammation/autoimmunity.
01/16/19
UBSW
01/16/19
DOWNGRADE
Target $82
UBSW
Neutral
Incyte downgraded to Neutral from Buy at UBS
UBS analyst Carter Gould downgraded Incyte to Neutral while raising his price target for the shares to $82 from $75. The 36% rally in the shares since December 24, 2018 has largely stemmed from sector consolidation while company fundamentals remained unchanged, Gould tells investors in a research note. As such, the analyst sees a more balanced risk/reward profile at current share levels. Further, over the first half of 2019, Gould does not see a clinical catalyst offering meaningful upside for Incyte shares.

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