Breaking News Instant updates and real-time market news.

DMAC

DiaMedica Therapeutics

$3.50

-0.16 (-4.37%)

07:50
01/22/19
01/22
07:50
01/22/19
07:50

DiaMedica Therapeutics announces publication of paper on KLK1, AIS

DiaMedica Therapeutics announced the publication of a paper in the peer reviewed journal, Therapeutic Advances in Neurological Disorders, or TAND. The paper summarizes the mechanistic rationale for using KLK1 to treat patients with acute ischemic stroke, or AIS, and summarizes human preclinical and clinical data supporting the hypothesis that KLK1 treatments may improve outcomes after AIS. KLK1, is a serine protease that plays a critical role in the regulation of microcirculation, blood pressure and blood flow. Multiple lines of evidence indicate that KLK1 is important for a healthy cardiovascular system and that deficits in KLK1 are associated with cardiovascular and end-organ pathology. Importantly, KLK1 replenishment therapy is widely used in Asia where multiple forms are used to treat diseases ranging from AIS to complications of diabetes. These diseases involve poor microcirculation or tissue ischemia, which leads to a hypothesis that directly boosting KLK1 levels will improve blood flow and protect tissue under ischemic conditions. The TAND paper reviews the scientific literature covering the biochemical role of KLK1 and presents the mechanistic rationale for using KLK1 as an additional pharmacological treatment for AIS. In addition to the biochemical mechanism of KLK1, the review highlights supporting results from human genetics and preclinical animal models of brain ischemia. It also reviews published clinical results for treatment of AIS by a form of KLK1 that is isolated from human urine. This form has been approved for post-infarct treatment of AIS in the People's Republic of China and data has been published on clinical trials involving over 4,000 patients. The paper offers a series of testable therapeutic hypotheses for demonstrating the long-term beneficial effect of KLK1 treatment in AIS patients and the reasons for this action.

DMAC DiaMedica Therapeutics
$3.50

-0.16 (-4.37%)

01/03/19
CHLM
01/03/19
INITIATION
Target $9
CHLM
Buy
DiaMedica Therapeutics initiated with a Buy at Craig-Hallum
Craig-Hallum analyst Alexander Nowak started DiaMedica Therapeutics with a Buy rating and a $9 price target. The analyst believes its unique stroke and kidney treatment validated in China sets up DiaMedica as a high reward opportunity, while positive Phase 2 results could move the stock above his price target.

TODAY'S FREE FLY STORIES

TWTR

Twitter

$33.70

1.11 (3.41%)

11:05
03/26/19
03/26
11:05
03/26/19
11:05
Options
Twitter call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 27

    Mar

  • 04

    Apr

  • 23

    Apr

AAPL

Apple

$191.80

3.02 (1.60%)

, AMZN

Amazon.com

$1,799.88

25.86 (1.46%)

11:04
03/26/19
03/26
11:04
03/26/19
11:04
On The Fly
Apple rises as Wall Street weighs in on 'incremental' services announcements »

Shares of Apple (AAPL)…

AAPL

Apple

$191.80

3.02 (1.60%)

AMZN

Amazon.com

$1,799.88

25.86 (1.46%)

ROKU

Roku

$65.23

-1.56 (-2.34%)

CMCSA

Comcast

$39.58

0.37 (0.94%)

CMCSK

Comcast

$0.00

(0.00%)

NFLX

Netflix

$362.80

-3.56 (-0.97%)

SSNLF

Samsung

$0.00

(0.00%)

WMT

Walmart

$98.72

0.55 (0.56%)

GDOT

Green Dot

$60.20

-0.85 (-1.39%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 26

    Mar

  • 26

    Mar

  • 26

    Mar

  • 29

    Mar

  • 29

    Mar

  • 04

    Apr

  • 25

    Apr

  • 16

    May

  • 03

    Jun

ULTI

Ultimate Software

$328.88

-0.91 (-0.28%)

10:59
03/26/19
03/26
10:59
03/26/19
10:59
Downgrade
Ultimate Software rating change  »

Ultimate Software…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

ULTI

Ultimate Software

$329.03

-0.76 (-0.23%)

10:52
03/26/19
03/26
10:52
03/26/19
10:52
Downgrade
Ultimate Software rating change  »

Ultimate Software…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MO

Altria Group

$56.98

0.38 (0.67%)

10:50
03/26/19
03/26
10:50
03/26/19
10:50
Options
At-the-money put buyers in Altria weeklies »

At-the-money put buyers…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 16

    May

CLD

Cloud Peak

$0.16

-0.0022 (-1.35%)

10:48
03/26/19
03/26
10:48
03/26/19
10:48
Hot Stocks
Breaking Hot Stocks news story on Cloud Peak »

Cloud Peak trading…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

10:48
03/26/19
03/26
10:48
03/26/19
10:48
Conference/Events
Morgan Stanley IT hard/software analyst to hold analyst/industry conference call »

IT Hardware Analyst…

10:45
03/26/19
03/26
10:45
03/26/19
10:45
General news
Breaking General news story  »

8-Week Bill Announcement…

10:45
03/26/19
03/26
10:45
03/26/19
10:45
General news
Breaking General news story  »

4-Week Bill Announcement…

EYEG

EyeGate

$0.35

-0.035 (-9.09%)

10:42
03/26/19
03/26
10:42
03/26/19
10:42
Hot Stocks
EyeGate ready to move forward with pivotal study after FDA meeting »

EyeGate Pharmaceuticals…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

ORCL

Oracle

$53.32

0.6 (1.14%)

10:40
03/26/19
03/26
10:40
03/26/19
10:40
Options
3.1K Oracle Jun 50 - Sep 52.5 call spreads bought for 80c »

3.1K Oracle Jun 50 - Sep…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

10:40
03/26/19
03/26
10:40
03/26/19
10:40
General news
Asia's Export Slump: »

Asia's Export Slump:…

ALDX

Aldeyra

$10.89

3.75 (52.52%)

10:36
03/26/19
03/26
10:36
03/26/19
10:36
Recommendations
Aldeyra analyst commentary at Cantor Fitzgerald »

Aldeyra price target…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 26

    Mar

10:35
03/26/19
03/26
10:35
03/26/19
10:35
General news
Atlanta Fed's Q1 GDPNow estimate was lifted to 1.3% »

Atlanta Fed's Q1…

10:35
03/26/19
03/26
10:35
03/26/19
10:35
General news
U.S. Consumer confidence posted a surprising drop »

U.S. Consumer confidence…

TPX

Tempur Sealy

$57.11

0.9 (1.60%)

10:31
03/26/19
03/26
10:31
03/26/19
10:31
Recommendations
Tempur Sealy analyst commentary at BofA/Merrill »

Tempur Sealy gaining…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

ENDP

Endo

$8.90

0.635 (7.68%)

10:30
03/26/19
03/26
10:30
03/26/19
10:30
Options
Bullish flow in Endo International as shares gain 9.3% »

Bullish flow in Endo…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

10:30
03/26/19
03/26
10:30
03/26/19
10:30
General news
Fed funds futures are lower »

Fed funds futures are…

LUV

Southwest

$49.19

0.5 (1.03%)

10:29
03/26/19
03/26
10:29
03/26/19
10:29
Hot Stocks
Teamstres material specialists ratify agreement at Southwest »

With over 90% of the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

CRTO

Criteo

$19.24

-2.75 (-12.51%)

, GOOG

Alphabet

$1,195.53

2.81 (0.24%)

10:25
03/26/19
03/26
10:25
03/26/19
10:25
Downgrade
Criteo, Alphabet, Alphabet Class A rating change at Rosenblatt »

Criteo downgraded to…

CRTO

Criteo

$19.24

-2.75 (-12.51%)

GOOG

Alphabet

$1,195.53

2.81 (0.24%)

GOOGL

Alphabet Class A

$1,200.55

3.42 (0.29%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 27

    Mar

  • 04

    Apr

  • 29

    Apr

  • 29

    Apr

  • 27

    Oct

10:25
03/26/19
03/26
10:25
03/26/19
10:25
Conference/Events
Morgan Stanley gaming analysts to hold an analyst/industry conference call »

Analysts, along with the…

SYNA

Synaptics

$34.01

1.3 (3.97%)

10:20
03/26/19
03/26
10:20
03/26/19
10:20
Options
Synaptics calls active as shares rally »

Synaptics calls active as…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 28

    May

10:20
03/26/19
03/26
10:20
03/26/19
10:20
General news
U.S. Richmond Fed manufacturing index fell 6 points to 10 in March »

U.S. Richmond Fed…

10:20
03/26/19
03/26
10:20
03/26/19
10:20
General news
Treasury Action: yields continued to recline »

Treasury Action: yields…

$NSD

NASDAQ Market Internals

$0.00

(0.00%)

10:17
03/26/19
03/26
10:17
03/26/19
10:17
Technical Analysis
NASDAQ market internals summary »

Volume is above average…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.