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COCP

Cocrystal Pharma

$3.90

0.02 (0.52%)

, GILD

Gilead

$69.21

0.56 (0.82%)

08:18
01/22/19
01/22
08:18
01/22/19
08:18

Cocrystal Pharma announces safety, preliminary efficacy data for CC-31244

Cocrystal Pharma (COCP) announced safety and preliminary efficacy data for its U.S. Phase 2a study evaluating CC-31244 for the ultra-short treatment of HCV infected individuals. CC-31244 is an investigational, oral, potent, broad-spectrum replication inhibitor called a non-nucleoside inhibitor, or NNI. Epclusa is an approved 12-week therapy for HCV developed by Gilead (GILD). The U.S. Phase 2a study is an open-label study designed to evaluate the safety, tolerability, and preliminary efficacy of CC-31244 with Epclusa in 12 subjects with treatment-naive HCV genotype 1. Subjects received oral 400 mg of CC-31244 and Epclusa for 2 weeks. Following this, the subjects continued Epclusa treatment alone for another 4 weeks. All subjects completed the 6-week treatment regimen. The treatment was well tolerated with no study discontinuations due to adverse events. Eight of 12 subjects achieved the primary efficacy endpoint of sustained virologic response at 12 weeks after completion of treatment, or SVR12. SVR12 is defined as undetectable virus in blood 12 weeks after completion of treatment and considered a virologic cure. Plans are underway to commence the second study in the HCV clinical development program, a Phase 2a study in Hong Kong evaluating the safety, tolerability and preliminary efficacy of CC-31244 in combination with sofosbuvir and daclatsavir with or without a protease inhibitor, for the treatment of hepatitis C. The Humanity & Health Research Centre expects to commence the study in Q1. The upcoming, Hong Kong Phase 2a open-label trial differs from the current Phase 2a trial Cocrystal is conducting by use of a protease inhibitor as part of the combination regimen and a shorter treatment duration.

COCP

Cocrystal Pharma

$3.90

0.02 (0.52%)

GILD

Gilead

$69.21

0.56 (0.82%)

  • 28

    Jan

  • 18

    May

COCP Cocrystal Pharma
$3.90

0.02 (0.52%)

07/17/18
EROP
07/17/18
INITIATION
Target $14
EROP
Buy
Cocrystal Pharma initiated with a Buy at Euro Pacific
Euro Pacific initiated Cocrystal Pharma with a Buy and $14 price target.
GILD Gilead
$69.21

0.56 (0.82%)

01/03/19
01/03/19
UPGRADE
Target $85

Outperform
Gilead upgraded to Outperform at Oppenheimer as strong clinical data approaches
As previously reported, Oppenheimer analyst Hartaj Singh upgraded Gilead to Outperform from Perform, with a $85 price target. The analyst believes that in 2019 the addition of CEO Daniel O'Day, year-on-year sales growth, and important mid/late-stage clinical readouts for budding franchises in inflammation and NASH could start to re-rate a biotech bellwether, a name that is among the cheapest in large-cap biotech. After a 3-year stretch where the company lost almost 1/3 of its top line with slowing HCV sales, Singh thinks Gilead is poised to get its "mojo back," delivering on P&L fundamentals, mid/late-stage pipeline progression and a burgeoning acquisition/licensing heightened by O'Day's previous experience.
01/03/19
OPCO
01/03/19
UPGRADE
OPCO
Outperform
Gilead upgraded to Outperform from Perform at Oppenheimer
12/19/18
CANT
12/19/18
NO CHANGE
Target $92
CANT
Overweight
Gilead price target raised to $92 from $88 at Cantor Fitzgerald
Cantor Fitzgerald analyst Alethia Young raised her price target for Gilead Sciences (GILD) to $92 after her firm increased its peak 2027 filgotinib sales estimate from $2.75B to $4.0B. Gilead books revenues in the U.S. and ~20% of sales are outside the U.S., so filgotinib is a key pipeline product not only for Galapagos NV (GLPG), but also for Gilead, Young tells investors in a research note. She reiterates an Overweight rating on the shares.
12/17/18
GUGG
12/17/18
INITIATION
Target $86
GUGG
Buy
Gilead resumed with a Buy at Guggenheim
Guggenheim analyst Whitney Ijem resumed coverage of Gilead Sciences with a Buy rating and $86 price target. With management uncertainty "now moving into the rearview mirror," the analyst likes the shares heading into 2019. She thinks Gilead's base business is positioned well and points out the company has several Phase 3 data readouts next year. Ijem calls Selonsertib a "coin-flip" but believes filgotinib data is likely to be positive.

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MCD

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SSNLF

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AWR

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MYOK

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CTMX

CytomX Therapeutics

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HPQ

HP Inc.

$18.97

-0.4 (-2.07%)

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PEGA

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SMTC

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TMO

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MCD

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BA

Boeing

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ACHC

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NOC

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