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TCON

TRACON Pharmaceuticals

$0.95

-0.09 (-8.65%)

09:26
01/22/19
01/22
09:26
01/22/19
09:26

TRACON Pharmaceuticals presents data from TRC105, Nexavar study at ASCO

TRACON Pharmaceuticals announced that "positive" clinical data from its ongoing Phase 1b/2 study of TRC105 and Nexavar in patients with advanced hepatocellular carcinoma, or HCC, were presented in a poster presentation at the ASCO 2019 Gastrointestinal Cancers Symposium. Data from the ongoing open-label, non-randomized study were presented. Confirmed partial response by RECIST 1.1 occurred in 3 of 15 evaluable patients and a reduction of 50% or greater in alpha fetoprotein, or AFP, concentration occurred in 8 of 16 evaluable patients. Reduction in AFP, a tumor marker expressed in patients with HCC, in early treatment may help predict a favorable response to treatment. Adverse events expected of each drug did not increase in frequency or severity when TRC105 and sorafenib were administered concurrently. TRC105 trough concentrations were lower in HCC patients compared with prior TRC105 studies in other tumor types, and weekly dosing at the recommended Phase 2 dose of TRC105 of 10 mg/kg, rather than every other week dosing, was required to exceed target concentrations consistently. This may reflect increased target mediated clearance in HCC patients via fibrotic/cirrhotic liver disease. Anti-drug antibody was observed more frequently in patients with HCC compared with prior studies of TRC105 in other tumor types and may have influenced pharmacokinetics in individual patients.

  • 20

    Feb

TCON TRACON Pharmaceuticals
$0.95

-0.09 (-8.65%)

12/26/18
BTIG
12/26/18
NO CHANGE
Target $9
BTIG
Buy
TRACON Pharmaceuticals price target lowered to $9 from $13 at BTIG
BTIG analyst Robert Hazlett lowered his price target on TRACON Pharma to $9 after the company's recent announcement that its Phase 2b TRAXAR trial of TRC105+Intyla in renal cell carcinoma, or RCC, did not meet the primary endpoint of improving progression free survival. The analyst states that the findings have led him to remove the RCC estimates from his model, leading to a lower price target. Hazlett is keeping his Buy rating on Tracon Pharma as he continues to have "material expectations for 105 in angiosarcoma, as well as its opportunities in wet AMD with DE-122 and prostate cancer with TRC253.
05/10/18
NEED
05/10/18
NO CHANGE
Target $8
NEED
Buy
TRACON Pharmaceuticals price target lowered to $8 from $16 at Needham
Needham analyst Chad Messer lowered his price target on TRACON Pharmaceuticals to $8 after its Q1 earnings miss as well as to reflect the dilution from its recent equity raise. Longer term, Messer keeps his Buy rating, noting Tracon's value drivers this year remain the "interim analysis of the pivotal TAPPAS study of TRC105 in angiosarcoma and randomized Phase II TRAXAR data testing TRC105+Inlyta in renal cell carcinoma".

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BA

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ACHC

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NOC

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