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DRNA

Dicerna

$10.15

-0.12 (-1.17%)

07:32
01/28/19
01/28
07:32
01/28/19
07:32

Dicerna doses first volunteer in Phase 1 clinical trial of DCR-HBVS

Dicerna Pharmaceuticals announced the dosing of the first human volunteer in its Phase 1 clinical trial of DCR-HBVS, the Company's investigational GalXC-based therapy for the treatment of chronic hepatitis B virus infection in adults. The Company anticipates human proof-of-concept data from the Phase 1 trial, which is known as DCR-HBVS-101, in the second half of 2019. DCR-HBVS is comprised of a single GalXC molecule that targets HBV messenger RNAs within the hepatitis B surface antigen gene sequence region. Preclinical studies with a standard mouse model of HBV infection showed DCR-HBVS led to greater than 99% reduction in circulating HBsAg, suggesting superior HBsAg suppression, compared to targeting within the X gene sequence region.

DRNA Dicerna
$10.15

-0.12 (-1.17%)

11/06/18
RILY
11/06/18
UPGRADE
Target $21
RILY
Buy
Dicerna upgraded to Buy from Neutral at B. Riley FBR
B. Riley FBR analyst Madhu Kumar upgraded Dicerna Pharmaceuticals to Buy and raised his price target for the shares to $21 from $13.50 following last night's Q3 results. The analyst says Dicerna's "strong" balance sheet supports its "broad" RNAi platform.
11/27/18
LEER
11/27/18
INITIATION
Target $24
LEER
Outperform
Dicerna initiated with an Outperform at Leerink
Leerink analyst Mani Foroohar initiated Dicerna with an Outperform rating and a price target of $24.
11/27/18
LEER
11/27/18
INITIATION
LEER
Leerink initiates select Genetic Medicine names on increasing regulatory clarity
Leerink analyst Mani Foroohar initiated select Genetic Medicine stocks, stating that the field is "is rich with companies developing drugs" to treat rare diseases and that he is increasingly more bullish on "innovation velocity and increasing regulatory clarity in the sector. Based on his "balanced view of pricing dynamics", the analyst issues an Outperform rating on Wave Life Sciences (WVE), Rocket Pharmaceuticals (RCKT), Intellia Therapeutics (NTLA), Eidos Therapeutics (EIDX), Dicerna (DRNA) and Bluebird Bio (BLUE). The analyst likes Wave Life Sciences as a pure play on Oligotherapeutics and its stereopure chemistry platform as a differentiated approach to oligo drug design. Foroohar is positive on Rocket Pharma's lead assets in gene therapies for Fanconi Anemia and Leukocyte Adhesion Deficiency-I "which will likely be the company's first potential approved product." The analyst is positive on Intellia Therapeutics' "robust balance sheet to support development, trading at a material discount to closest comps peers". For Eidos, the analyst cites the prospects of its drug candidate for TTR amyloidosis currently in a placebo-controlled Phase 2 study that may offer a competitive profile relative to Pfizer's (PFE) tafamidis. For Dicerna, Foroohar notes that its DCR-PHXC "is an RNAi therapeutic that targets lactate dehydrogenase A for the treatment of all subtypes of Primary Hyperoxaluria vs. competitor Alnylam's (ALNY) lumasiran, which only treats PH Type 1. For Bluebird Bio, the analyst is positive on its position as a "leader in ex vivo gene therapy, with four programs with visibility towards near-term regulatory approval". Foroohar initiates Avrobio (AVRO), Alnylam (ALNY), and Ionis Pharmaceuticals (IONS) with Market Perform rating based on competitive launches for their products along with "mixed" early signs of their results. The analyst also rates Regenxbio (RGNX) at underperform, saying that its "current valuation more than accounts for robust royalty streams from sales in spinal muscular atrophy" and other partnered assets.
01/22/19
CHDN
01/22/19
UPGRADE
CHDN
Buy
Dicerna upgraded to Buy from Neutral at Chardan

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AMZN

Amazon.com

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AKS

AK Steel

$2.45

0.055 (2.30%)

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NUE

Nucor

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STLD

Steel Dynamics

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TMST

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ABN Amro

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Zurich Insurance

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STT

State Street

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TLF

Tandy Leather

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AAPL

Apple

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BKNG

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GLD

SPDR Gold Shares

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TECK

Teck Resources

$16.48

0.11 (0.67%)

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OSK

Oshkosh

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OVLY

Oak Valley Bancorp

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-0.16 (-0.97%)

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FTNW

FTE Networks

$0.79

-0.0185 (-2.29%)

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TNXP

Tonix Pharmaceuticals

$0.45

0.0048 (1.07%)

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RLMD

Relmada Therapeutics

$20.18

1.07 (5.60%)

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16:55
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Breaking General news story  »

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NWSA

News Corp.

$13.48

-0.19 (-1.39%)

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News Corp

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News Corp.

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News Corp

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FB

Facebook

$185.96

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NYT

New York Times

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0.21 (0.71%)

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WAIR

Wesco Aircraft

$11.01

0.01 (0.09%)

16:46
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Conference/Events
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FOMX

Foamix

$3.15

-0.09 (-2.78%)

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Breaking Hot Stocks news story on Foamix »

Foamix up 7.5% at $3.35…

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