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CBIO

Catalyst Biosciences

$8.59

0.21 (2.51%)

08:17
02/08/19
02/08
08:17
02/08/19
08:17

Catalyst Biosciences presents interim FVIIa data at EAHAD

Catalyst Biosciences presented updated interim data from the Phase 2/3 trial of subcutaneous prophylactic Factor VIIa, or FVIIa, variant marzeptacog alfa currently being developed for the treatment of hemophilia A or B with inhibitors. The data were delivered in an oral presentation at the annual congress of the European Association for Haemophilia and Allied Disorders, or EAHAD. The company presented the updated results which include data from a total of 11 subjects. Seven subjects have completed dosing in the trial, two are currently dosing, others are completing screening and enrollment is now complete. To date, for all enrolled patients, the mean annualized bleed rate, or ABR, prior to the trial was 19 bleeds per year. All subjects who have completed dosing have had clinically significant reductions in ABR and five experienced no bleeds with individualized dosing of either 30 microg/kg MarzAA or 60 microg/kg MarzAA for 50 days. Six subjects had no spontaneous bleeds at their final dose level. The median proportion of days with bleeding for the seven subjects during the pre-study period was 11% and this was significantly reduced to a median of 1% during the treatment period. A total of more than 450 days of subcutaneous dosing of MarzAA have been completed with only six localized skin reactions in two subjects, and no anti-drug antibodies to MarzAA have been detected to date. An additional aim of the study is to examine the quality of life, or QOL, of individuals who have inhibitors. Results of the analysis have shown that QOL is measurably worse in those with inhibitors compared with those without inhibitors. Interim results after treatment for 50 days with subcutaneous MarzAA showed an improvement in the QOL of individuals, as measured using the Haemophilia quality of life questionnaire and the Haemophilia activity list.

CBIO Catalyst Biosciences
$8.59

0.21 (2.51%)

06/21/18
RILY
06/21/18
DOWNGRADE
Target $12.5
RILY
Neutral
Catalyst Biosciences downgraded to Neutral from Buy at B. Riley FBR
B. Riley FBR analyst George Zavoico downgraded Catalyst Biosciences to Neutral and cut his price target for the shares to $12.50 from $44.
06/21/18
06/21/18
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Nike (NKE) downgraded to Neutral from Buy at UBS with analyst Jay Sole saying Nike's "comeback after two relatively down years continues." 2. Infinera (INFN) downgraded to Neutral from Buy at Goldman Sachs with analyst Rod Hall assumed coverage from Doug Clark and downgrading the stock to Neutral from Buy while saying the company's success is dependent on the new products, while its "key higher TAM products are yet to fully hit the market." 3. AMC Networks (AMCX) downgraded to Underperform from Market Perform at Bernstein with analyst Todd Juenger saying he thinks it is unlikely the company will be acquired at a premium. 4. Catalyst Biosciences (CBIO) downgraded to Neutral from Buy at B. Riley FBR. 5. Noble Corp. (NE) downgraded to Hold from Buy at Jefferies with analyst Eduardo Royes saying the stock is up 18% year-to-date versus its four major peers rising only 2%. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
01/04/19
01/04/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Aveo Pharmaceuticals (AVEO) initiated with an Outperform at Baird. 2. Catalyst Biosciences (CBIO) initiated with Outperform at Oppenheimer. 3. Infinity Pharmaceuticals (INFI) initiated with a Buy at B. Riley FBR. 4. Rockwell Automation (ROK) resumed with a Hold at Deutsche Bank. 5. Dell Technologies (DELL) initiated with a Buy at BofA/Merrill. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
01/03/19
OPCO
01/03/19
INITIATION
Target $24
OPCO
Outperform
Catalyst Biosciences initiated with Outperform at Oppenheimer
Oppenheimer analyst Kevin DeGeeter initiated Catalyst Biosciences with an Outperform rating and a price target of $24. The analyst notes that the company offers a "unique approach" in hemophilia treatment, asking key questions about the "best method to transition inhibitor patients from products designed to treat bleeding to prophylaxis for preventing bleeds" and the optimal treatment of "pediatric hemophilia B patients that are not candidates for subcutaneous non-factor replacement therapies or gene therapy". DeGeeter contends that investors are under-appreciating Catalyst Biosciences' Factor VIIa program and anticipates the investment story for the stock to solidify this year.

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