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ACHV

Achieve Life Sciences

$1.72

0.01 (0.58%)

05:33
02/20/19
02/20
05:33
02/20/19
05:33

Achieve Life Sciences completes enrollment in ORCA-1 trial of cytisinicline

Achieve Life Sciences announced the completion of full enrollment in the ORCA-1 trial of cytisinicline. ORCA-1 is the first in Achieve's Ongoing Research of Cytisinicline for Addiction, or ORCA, Program, which aims to evaluate the effectiveness of cytisinicline for smoking cessation and potentially other addiction indications. The Phase 2b trial is evaluating a 25-day treatment course of 1.5 mg or 3.0 mg doses of cytisinicline using either a declining titration schedule or three times daily dosing. The trial is randomized and blinded to compare the effectiveness of the cytisinicline doses and schedules to respective placebo groups. The primary efficacy endpoint is the overall reduction in the number of cigarettes smoked during the treatment period, with secondary analyses being conducted on smoking cessation rates, safety, and compliance. Smokers who are participating in the trial receive standardized behavioral support. ORCA-1 was initiated in October 2018 and enrolled 254 smokers at eight centers across the United States. The trial's Data Safety Monitoring Committee met recently and concluded there are no safety concerns for subjects and the trial should continue as planned. ORCA-1 topline efficacy and safety data are expected to be announced in mid-2019.

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CLVS

Clovis

$4.76

-0.1 (-2.06%)

05:38
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05:38
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Clovis acquires rights to FAP »

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TRV

Travelers

$146.32

-0.69 (-0.47%)

05:37
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Travelers receives approval to transfer European business to Dublin »

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DEA

Easterly Government Properties

$20.96

0.02 (0.10%)

05:37
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Easterly Government Properties initiated  »

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TEL

TE Connectivity

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-1.21 (-1.28%)

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SWDBY

Swedbank

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ESLOY

EssilorLuxottica

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CHWY

Chewy

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-1.06 (-3.85%)

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AEXAY

Atos

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BIIB

Biogen

$238.80

3.2 (1.36%)

05:28
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Biogen says Plegridy, Avonex receive 'positive opinion' from CHMP »

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ACN

Accenture

$192.99

-1.78 (-0.91%)

05:28
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Accenture initiated  »

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TELDF

Telefonica Deutschland

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EGY

VAALCO Energy

$2.08

0.06 (2.97%)

05:26
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VAALCO Energy initiated  »

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PCG

PG&E

$11.64

-0.565 (-4.63%)

05:25
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PG&E expects to turn off power late Monday in nine CA counties due to fire risk »

Pacific Gas and Electric…

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AIBRF

AIB Group

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OAOFY

Tatneft

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ESYJY

easyJet

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VLOWY

Vallourec

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TELNY

Telenor

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ANNSF

Aena

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AAPL

Apple

$217.69

-3.22 (-1.46%)

05:13
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Apple analyst commentary  »

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DXCM

DexCom

$154.45

-0.49 (-0.32%)

, ABT

Abbott

$83.56

0.35 (0.42%)

05:04
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Recommendations
DexCom, Abbott analyst commentary  »

DexCom remains a…

DXCM

DexCom

$154.45

-0.49 (-0.32%)

ABT

Abbott

$83.56

0.35 (0.42%)

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  • 24

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EW

Edwards Lifesciences

$219.56

4.45 (2.07%)

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Edwards Lifesciences initiated  »

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ITW

Illinois Tool Works

$155.05

-0.91 (-0.58%)

, HON

Honeywell

$168.42

1.7 (1.02%)

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ITW

Illinois Tool Works

$155.05

-0.91 (-0.58%)

HON

Honeywell

$168.42

1.7 (1.02%)

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  • 17

    Oct

HR

Healthcare Realty Trust

$33.17

-0.155 (-0.47%)

04:55
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04:55
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04:55
Conference/Events
Healthcare Realty Trust management to meet with Capital One »

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  • 23

    Sep

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NBIX

Neurocrine

$100.74

-0.77 (-0.76%)

04:55
09/23/19
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04:55
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04:55
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Neurocrine participates in a conference call with JPMorgan »

SMid Biotechnology…

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  • 23

    Sep

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